OBJECTIVE:To analysis the micro-policy demand of medical institutions about carrying on qualified phar?maceutical service.METHODS:To compare the difference of pharmaceutical service and the policy between domestic and ov_ ersea medical institutions.RESULTS&CONCLUSION:To develop the pharmaceutical service of our country,the governm_ ent and authority should establish the encouraging and regulative policies about education,medicine,licensed pharmacist,personnel matters management,and so on.

Positive and meaningful exploration was conducted by related teachers to improve the teaching quality of oral clinical pharmacology.Case based teaching method was applied in the teaching of adverse reactions and bilingual teaching was employed in the teaching of local anesthesia.Correlation and comparison of the key knowledge points were emphasized in the teaching process. Students′ interests were aroused and satisfactory results were achieved through implementing these measures.

Cholesteatoma, Middle Ear ; surgery ; Ear, Middle ; Humans

Bone and Bones ; drug effects ; metabolism ; Humans ; Lead ; adverse effects ; Osteogenesis ; drug effects

Information Services ; Occupational Health Services ; organization & administration

Objective To evaluate the efficacy and safety of etoricoxib and meloxicam in the treatment of patients with acute gout. Methods A randomized,active comparator study was conducted at outpatients and inpatients in our hospital from January 2009 to July 2010.A total of 84patients aged (63.7± 11.0) years with an acute attack of gout were treated with etoricoxib 120 mg/d (n =48),or meloxicam 15 mg/d (n =36) for 7 d.The patient's assessment of joint pain (0- 4 point Likert scale) at drug treatment for 2-5 d was considered as the primary efficacy end point,4 h after firstly takiug the drug and 2-8 d after treatment as the secondary efficacy end point.The starting efficacy was determined until pain relieved by patient himself. The safety was assessed by adverse experiences and indexes including leucocyte, platelet,crcatinine, uric acid,alanine transaminase (ALT),aspartate transaminase (AST) and mean artery pressure(MAP). Results In 84 patients,3cases (8.3％) in meloxicam treatment and 15 cases (31.2％) in etoricoxib treatment (among which 13 cases finished treatment) discontinued therapy.The improvement scores of joint pain were (-0.41 ±0.35 vs.-0.19±0.30,P=0.005) at4 h after firstly taking the drug,(-1.66±0.58 vs. 1.38±0.44,P=0.018)at drug treatment for 2 -5 d,( - 1.83 ± 0.60 vs.- 1.85 ± 0.53,P=0.9) at 2 8 d after treatment,and (-2.64±0.45 vs. - 2.38±0.37,P=0.000) post-treatment higher than pre treatment.The starting time of pain relieving were (4.0 ± 4.6) h in etoricoxib treatment and (12.1±5.7) h in meloxicam treatment. The levels of leucocyte were decreased after treatment as compared with before treatment in both two drug treatments(P＜0.05),while no differences were found in platelet.creatinine,uric acid,ALT and AST.MAP after etoricoxib treatment was increased compared with pretreatment ( P ＜ 0.05 ). Drug related adverse experiences appeared in 15 cases (31.2 ％ ) in etoricoxib treatment and 12 cases(33.3 ％ ) in meloxicam treatment(P=1.000).The ratio of gastrointestinal tract-related adverse effects in meloxicam treatment was higher than in etoricoxib (22.2％ vs.6.2％,P＜ 0.05),while adverse effects on cardiovascular in etoricoxib treatment were comparable to that of meloxicam (16.7 ％ and 11.1 ％,P＞0.05). Conclusions Etoricoxib at a dose of 120 mg once daily may be more effective than meloxicam for acute gout in aspects of safety and tolerance.

Child ; Humans ; Motor Skills Disorders ; diagnosis ; therapy

Objective To evaluate the therapeutic effect of radiofrequency endovenous obliteration (RFO) on superficial varicosities in lower extremity in the elderly. Methods The clinical data of 35 elderly patients (43 limbs) with primary great saphenous varicose vein, who were treated with RFO (20 limbs) or RFO in combination with high ligation procedures (23 limbs), were analyzed retrospectively. The therapeutic effects were evaluated at 1-3 years after RFO by the improvement of clinical symptom and signs, as well as results of color Doppler ultrasonography. Results Compared with single RFO group, the obstruction rate of great saphenous vein was higher [21(91.3%) vs. 14(70.0%), χ2 =5.467, P < 0. 05], and the recanalization rate was lower [2(8.7%) vs. 8(30.0%),χ2=4.251, P<0.05] in RFO combined with high ligation group. The recurrence rate of local varicose veins was lower[0 vs. 4(20. 0%),χ2 =7. 030, P<0. 013 in RFO plos high ligation group than in single RFO group. Conclusions RFO is an effective treatment with less trauma, more safety and less scars. Combined with high ligation procedure, the effectiveness may be better.

Congenital Abnormalities ; Encephalocele ; Humans ; Nose Diseases ; congenital

Multidrug resistant genes are highly expressed in hepatocellular carcinoma that seriousty affects the effect of chemotherapy. Screening of resistant genes from HCC cells and studying its mechanism of drug resistance will be helpful to improve the effecacy of chemotherapy for hepatocellular carcinoma. Here we described an alternative method called cyclical packaging rescue (CPR). First we constructed a retrovirus cDNA library of hepatoma cells and used it to infect fibroblasts. Then we added drugs to screen survival cells. The survival cells, stably integrated helper-free retroviral libraries, were recovered rapidly after transfection with plasmids expressing retroviral gag-pol and env genes. Through this method, retroviral RNAs were directly repackaged into new infectious virions. Recovered retroviral supernatant was then used to reinfect fresh target cells. When performed in concert with selection using functional assays, cDNAs regulating functional responses could be identified by enrichment through multiple rounds of retroviral library recovery and retransmission. Using CPR, we obtained several cDNAs. After a preliminary detection, we found Ribosomal protein S11 (RPS11), Ribosomal protein L6 (RPL6), Ribosomal protein L11 (RPL11), Ribosomal protein L24 (RPL24) possibly had drug resistant function.
Carcinoma, Hepatocellular ; genetics ; pathology ; Cell Line, Tumor ; DNA, Complementary ; Drug Resistance, Neoplasm ; genetics ; Gene Library ; Genetic Vectors ; Humans ; Liver Neoplasms ; genetics ; pathology ; Plasmids ; Retroviridae ; Ribosomal Proteins ; genetics ; metabolism ; Transfection