1.Conflicts of interests and its effects on informed content, protection of human subjects in translational medicine
Chinese Journal of Medical Science Research Management 2014;27(3):241-243,246
Medicine,law and ethics are closely related to each other.Translational medicine is a research model to promote basic research into clinical application rapidly.Its ultimate goal is to promote development of new drug and method as quickly as possible,to improve the level of clinical diagnostics and treatment for health promotion.But some new challenges we have to face in line with accelerating medical research from lab to bedside.There are some potential risk and ethical issues.Among them,conflicts of interest and its affection on implementation of informed consent and protection of human subjects has not been given sufficient attention.The conflict of interest should be managed allows people to exercise their rights as autonomous agents to make their own informed decisions and deter investigators and institutions from having significant conflicts of interest.
2.Management analysis and experience sharing of modern medical ethics
Chinese Journal of Medical Science Research Management 2012;25(4):281-283
To explore and discuss the challenge and solutions of medical ethics management in case of rapid development of medical research.Analyzed changes of the model,contents,and methods in modern medical research.Identified the significance of ethics review in medical research.Introduced some practices at Peking Union Medical College Hospital (PUMCH) in recent years.Ethical review is one of the key elements for quality of medical research. Management should be improved and strengthen for the protections of research subjects effectively in the case of rapid development of life science.
4.Mutant K-ras gene in pathogenesis of pancreatic ductal adenocarcinoma.
Chinese Journal of Pathology 2012;41(1):62-65
Animals
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Carcinoma, Pancreatic Ductal
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genetics
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pathology
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Genes, ras
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genetics
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Humans
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Metaplasia
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MicroRNAs
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genetics
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Mutation
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Pancreatic Ducts
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pathology
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Pancreatic Neoplasms
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genetics
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pathology
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Pancreatitis
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genetics
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Signal Transduction
5.Chemical constituents in fruit of Momordica charantia
Chinese Traditional and Herbal Drugs 1994;0(12):-
Objective To study the chemical constituents in the mature fruit of Momordica Charantia. Methods M. charantia was extracted by alcohol and then extracted by chloroform; isolation and purification were carried out by silica gel. Compounds were identified and elucidated by spectral and chemical methods. Results Five compounds were obtained and identified as aglycone of momordicoside F_1 (Ⅰ), 5, 25-stigmastadien-3-ol (Ⅱ), aglycone of momordicoside Ⅰ (Ⅲ), charantin (Ⅳ), and ?-sitosterol (Ⅴ). Conclusion For the first time, compound Ⅰ is found as the novel natural product and compound Ⅱ is found in the fruit of M. charantia in China.
6.Discussion of the intervention of social work in hospice
Chinese Journal of Hospital Administration 1996;0(01):-
With the development of the human society, people have come to pay more and more attention not only to their life quality but also to the quality of their life before death. Hence the emergence of hospice. At present there are three types of hospice in China: the family type, the general hospital type, and the special institution type. Each of these types has its own shortcomings. Hence the need for social work to intervene in hospice. The paper discusses the viability and necessity of the intervention through the notion, channels and methods of intervention. The role of social workers in hospice is also discussed.
7.Functions and characteristics of scientific research administration in modern hospitals
Chinese Journal of Medical Science Research Management 2010;23(4):220-224
Along with the globalization of science and technology, the investment on medical research has been increased gradually in recent years, which brings many challenges to the administration of scientific research. The traditional passive conception and model of research administration can no longer meet the needs of modern research development, and therefore changes are urgently needed. The function of research administration in modern medical research needs to be redefined and new characteristics will subsequently arise. The changes are believed helpful in promoting the efficiency of research funding and implementation of the research projects and further facilitating the transformation and application of research achievements.
8.Translational medical science:the medical science beneficial to patients
Basic & Clinical Medicine 2006;0(08):-
With the rapid development of life sciences, translational medical sciences have a new significance recent years. Translational medical science aims to eliminate the barriers between clinical, pharmaceutical drug breakthroughs and basic research, to shorten the distance from bench to bed side, and to facilitate rapid patient benefits from medical sciences. Translational medical science concurrently agrees with modern 21st century research trends, as well as emphasizing upon Chinese goals of health and sanitation (hygiene science), preventing and treating disease to preserve and improve health standards and quality of life. Following a long-term self study model of integrating basic with clinic research since 1921, Peking Union Medical College Hospital in collaboration with a variety of basic medical science institutions recently and initiated a pilot project of translational medical science in China.
9.Raloxifene combined with calcium phosphate cement for repair of rabbit mandibular defects
Chinese Journal of Tissue Engineering Research 2014;(25):3993-3997
BACKGROUND:Raloxifene is the third generation of selective estrogen receptor modulators, which can decrease bone loss, increase bone mineral content, and reduce fracture risk. OBJECTIVE: To study the effects of raloxifene combined with self-setting calcium phosphate cement on the repair of rabbit mandibular defects. METHODS:Totaly 36 New Zealand white rabbits were selected to prepare 8 mm×4 mm×3 mm mandibular defect models, and then randomized equaly into experimental group (raloxifene, 7.5 mg/kg per day, combined with self-setting calcium phosphate cement), drug group (raloxifene, 7.5 mg/kg per day), artificial bone group (self-setting calcium phosphate cement). Rabbits were sacrificed 4, 8 and 12 weeks later, respectively, for measurement of bone morphogenetic protein 2 using immunohistochemistry method and transforming growth factor β using a laser scanning confocal microscope. RESULTS AND CONCLUSION:After 4 and 8 weeks, the expression of bone morphogenetic protein 2 was obviously higher in the experimental group than the drug and artificial bone groups; after 12 weeks, bone remodeling was basicaly complete in the experimental group, and the expression of bone morphogenetic protein 2 became lower than that in the other two groups. The expression of transforming growth factor β in the experimental group was gradualy increased and reached the peak at 8 weeks, while in the drug and artificial bone groups, the expression of transforming growth factor β exhibited an increasing trend within 4-12 weeks, which was close to the peak. These findings suggest that raloxifene can promote early expression of bone morphogenetic proteins and early calus formation as wel as accelerate the repair of bone defects with calcium phosphate cement.
10.Trifluoperazine decreases scar thickness in a rabbit model of hypertrophic scar ear
Chinese Journal of Tissue Engineering Research 2014;(36):5764-5769
BACKGROUND:Conventional treatments for hypertrophic scars include excision, steroid hormones, anti-metabolite drugs, immunosuppressive agents and radiation therapy. Easy to relapse or serious reaction limits their clinical use. In recent years, application of calcium channel blockers in treatment of hypertrophic scars has made more good progresses, but little adverse reactions are obtained. OBJECTIVE:To explore the effects of calcium channel blocker trifluoperazine on hypertrophic scar of rabbit ears. METHODS:A total of 24 rabbits were enrol ed in this study. After 1 week of accommodation, models of rabbit ear scar were established in accordance with the method of Morris and Li et al. Rabbit models were randomly assigned to three group (n=8). At 30 days after model induction, when scar formed, trifluoperazine and triamcinolone acetonide groups received trifluoperazine and triamcinolone acetonide injection. Blank control group was left intact. Changes in hyperplastic scar, hypertrophic index, levels of matrix metal oproteinase-2, tissue inhibitor of metal oproteinase-2, transforming growth factorβ1,α-smooth muscle actin and proliferating cellnuclear antigen were compared and observed in each group. RESULTS AND CONCLUSION:At 10 and 20 days after treatment, in the three groups, skin bulge was visible in rabbit ears and no rabbit hair grew. Rabbit ears had obvious softening in the trifluoperazine group compared with the triamcinolone acetonide group, showing dark red. In the blank control group, rabbit ear scar was evident and showed red color. At 20 days after treatment, scar thickness and scar index were lower in the trifluoperazine and triamcinolone acetonide groups than in the blank control group. Matrix metal oproteinase 2 expression was significantly higher, but tissue inhibitor of metal oproteinase-2 and transforming growth factorβ1 levels were lower in the trifluoperazine and triamcinolone acetonide groups than in the blank control group. Results indicated that trifluoperazine obtained good proliferative effects on rabbit ear scar, and could decrease scar thickness.