1.The Role of Academic Forum in Postgraduates' Cultivation
Chinese Journal of Medical Education Research 2002;0(01):-
The goal of graduate students'cultivation is training talented persons with creativity.Academic forum plays an important role in graduate students' cultivation,which can stir up graduate students'creative thought and bring an atmosphere of studying hard.
2.Recent advance in peripheral T-cell lymphoma, not otherwise specified.
Chinese Journal of Pathology 2010;39(6):427-429
Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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CD3 Complex
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metabolism
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Chromosomes, Human, Pair 3
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Chromosomes, Human, Pair 5
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Cyclophosphamide
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therapeutic use
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Doxorubicin
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therapeutic use
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Gene Rearrangement, T-Lymphocyte
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Humans
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L-Lactate Dehydrogenase
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metabolism
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Lymphoma, T-Cell, Peripheral
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drug therapy
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genetics
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metabolism
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pathology
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Mutation
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Neoplasm Staging
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Prednisone
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therapeutic use
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Vincristine
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therapeutic use
3. Abnormal methylation of RASSF1A and BLU genes in renal carcinoma
Academic Journal of Second Military Medical University 2010;28(10):1068-1071
Objective: To investigate the methylation status of the promoters of RASSF1A and BLU genes in the renal carcinoma tissues and to assess their roles in the tumorigenesis of renal carcinoma. Methods: Methylation specific PCR (MSP) method was used to examine the methylation status of the promoters of RASSF1A and BLU genes in the renal carcinoma tissues of 26 patients with renal carcinoma and their corresponding adjacent normal tissues; and the results were analyzed. Results: We found that 17 (65.4%) of the renal carcinoma tissues had abnormal methylation of RASSF1A gene, and there was no abnormal methylation of RASSF1A in the adjacent normal tissues. Eleven(42.3%) of 26 renal cancer tissues had hypermethylation of BLU gene, and there was no hypermethylation of BLU gene in the corresponding adjacent tissues. Conclusion: Hypermethylation of RASSF1A and BLU genes is present in the renal carcinoma tissues, suggesting the hypermethylation of RASSF1A and BLU might be associated with the tumorigenesis of renal carcinoma.
4.Chemoprevention of colorectal cancer
Ping ZHOU ; Xinxing DUAN ; Jian LIU
Journal of International Oncology 2011;38(3):224-227
Chemoprevention is the use of natural or synthetic substances to prevent、suppress or to reverse the development of colorectal cancer.Aspirin and cox-2 inhibitor are the most effective preventive agents.However,the gastrointestinal and cardiovascular adverse effects limit the application.Recurrent adenomas can be markedly reduced by a combination of difluoromethylornithine and sulinclac and with few side effects.5-aminosalicylate and ursodeoxycholic acid have become the focus of inflammatory bowel disease.The double roles of folate need further study.Statins and EGFR inhibitors have some effects,which are in early clinical studies.The article reviews the new progress of chemoprevention of colorectal cancer.
6.Observation of the therapeutic efficacy of nasal septoplasty of nasal septal spur, ridge and/or elevated deviation in 134 cases under intranasal endoscopy
Lian DUAN ; Yuanhui JIAN ; Zhiyong WANG ;
Journal of Third Military Medical University 2003;0(11):-
Objective To observe the therapeutic efficacy of different operative methods for nasal septal spur/ridge elevated deviation. Methods A total of 134 patients with nasal septal spur/ridge elevated deviation were randomly divided into endoscopic surgery group and control group. Patients in the endoscopic group were treated with nasal septoplasty under intranasal endoscopy, while those in the control group were treated with traditional submucous correction of nasal septum. Therapeutic effects and causes of operative success were analyzed. Results The therapeutic efficacy in endoscopic surgery group was significantly superior to that in the control group ( P
7.Changes of Plasma Adrenomedullin Levels in Patients With IgA Nephropathy
Liying CAO ; Jian DUAN ; Hong GUO
Journal of Chinese Physician 2001;0(01):-
Objective To examine plasma adrenomedullin(ADM) levels in patients with IgA nephropathy,and investigate the correlation of plasma ADM and urinary albumin.Methods Specific radioimmunoassay was used to measure the plasma concentration of ADM in 35 patients with IgA nephropathy and 22 controls,and to analyse correlation of plasma ADM level and urinary albumin. Results The levels of plasma ADM (24 2?3 8)pg/ml was significantly higher in patients with IgA nephrophathy than that of controls(10 9?0 8)pg/ml)(P
8.Effect analysis of cataract surgery with transparent corneal incision in different direction by dual channel vision quality system
Jian CHEN ; Linghui LUO ; Guoping DUAN
Recent Advances in Ophthalmology 2017;37(3):251-254
Objective To investigate the effects of cataract surgery with transparent corneal incision in different directions,and discuss the application of dual channel visual quality analysis system in the evaluation of visual quality before and after cataract surgery.Methods Sixty-four patients (64 eyes) with cataract phacoemulsification combined with intraocuiar lens (IOL) implantation were enrolled in our hospital from January to May in 2016,and randomly divided into 2 groups:Group A with corneal incision in the temporal side of the eyes,group B with upper corneal incision.All the cases were examined with standard logarithmic optical acuity and dual-channel optical quality analysis system.The visual acuity,MTF cutoff,Strehl ratio (SR),objective scattering index (OSI) and contrast ratio were compared between the two groups.The OQAS values were 100%,20% and 9%.Results (1) The visual acuity and corrected visual acuity of all patients increased gradually from postoperative 1 day to 1 week (P <0.05),and the visual acuity gradually stabilized after 1 week.The uncorrected visual acuity and corrected visual acuity at postoperative 1 day and 1 week in group A were significantly higher than those in group B at the same time point(P < 0.05).There was no significant difference in uncorrected visual acuity and corrected visual acuity between the two groups at postoperative 1 month and 3 months (P > 0.05).(2) At postoperative 1 day and 1 week,the OSI values of two groups were higher than those before operation,and all the time points were statistically significant (all P < 0.05).The OSI values of group A at postoperative 1 day(2.81 ±0.89) and 1 week(1.98 ±0.73) were significantly lower than those of group B at 1 day(3.46 ± 1.17) and 1 week(2.61 ± 1.20) (all P < 0.05).There was no significant difference in OSI between postoperative 1 month and 3 months (all P > 0.05).The OV9% values of the two groups were increased at postoperative 1 day,1 week,1 month and 3 months,and all the time points were statistically significant(all P<0.05).The value of OV9% in group A at postoperative 1 day(0.29 ±0.09),1 week(0.33 ±0.12),1 month (0.37 ± 0.14) and 3 months (0.42 ± 0.17) were significantly higher than those in group B at 1 day (0.24 ± 0.10),1 week (0.27 ± 0.09),1 month (0.31 ± 0.09) and 3 months (0.34 ± 0.14),which was statistically significant (all P < 0.05).The MTF,SR,OV100% and OV20% values of all the patients were not statistically significant (all P > 0.05).Conclusion In the operation of cataract with the temporal and transparent corneal incision,the postoperative intraocular scattering is small,early visual recovery is fast and the visual quality is high.The long-term effect needs further study.Dual channel visual quality analysis system can further quantify the visual quality parameters,has certain advantage in visual quality assessment.
9.Treatment of maxillary lateral incisor with type Ⅲ dens invaginatus in a case
Zhiguo ZHENG ; Jian YANG ; Xiaolei DUAN
Journal of Practical Stomatology 2015;(2):298-299
Dens invaginatus is a relatively rare tooth malformations,this paper reports a case of lateral incisor with typeⅢdens invaginatus with periradicular pathosis and without pulp involvement.The tooth was treated by root canal therapy and followed up for one year,the prog-nosis was good.
10.Role of histamine on the expression of tight junctions gene in airway epithelia
Su DUAN ; Jian JIAO ; Luo ZHANG
Chinese Archives of Otolaryngology-Head and Neck Surgery 2015;(8):426-430
OBJECTIVE To investigate and elucidate the role of histamine on the regulation of tight junctions(TJs) gene expression of the airway epithelial cells. METHODS We cultured primary human bronchial epithelial cells from healthy and asthmatic individuals in the presence of histamine for 96 hours in air-liquid interface (ALI) culture system. The TJs expression on the level of mRNA and protein was determined by RT-qPCR and immunofluorescence (confocal microscopy), respectively. RESULTS A RT-qPCR analysis revealed that the mRNA expression of several TJs were up- or down-regulated by histamine. However, examination by confocal microscope revealed no detectable alterations in the morphology of the tight junctions after stimulating with histamine. CONCLUSION Our findings that histamine could regulate the mRNA expression of TJs of bronchial epithelial cells. That might contribute to the pathogenesis of chronic airway inflammatory diseases.