Actins ; metabolism ; Dermatofibrosarcoma ; classification ; pathology ; Desmin ; metabolism ; Head and Neck Neoplasms ; metabolism ; pathology ; Histiocytoma, Benign Fibrous ; classification ; metabolism ; pathology ; Histiocytoma, Malignant Fibrous ; classification ; metabolism ; pathology ; Humans ; Oncogene Proteins, Fusion ; metabolism ; Skin Neoplasms ; metabolism ; pathology ; Vimentin ; metabolism ; Xanthomatosis ; pathology

Chromosome Aberrations ; Gene Fusion ; Genes, Tumor Suppressor ; Humans ; Oncogene Proteins, Fusion ; metabolism ; Oncogenes ; Pathology ; standards ; trends ; Soft Tissue Neoplasms ; genetics ; metabolism ; pathology

Objective To evaluate the safety and effect of adefovir dipivoxil (ADV) on hepatitis B in HBeAgpositive patients.Methods 131 patients were divided into two groups randomly.Two groups were treated with ADV (10mg/d)and matrine (0.6g/d),respectively.The rate of HBV negative,the normalization rates of ALT,HBeAg loss and anfi-HBe seroconversion were evaluated respectively.Results After 12 weeks of treatment,the rate of HBV negative,the normalization rates of ALT,HBeAg loss and anti-HBe seroconversion of ADV were all significantly higher than those of matrine group(53.2％ vs 7.8％,36.0％ vs 8.7％,13.6％ vs 3.1％,6.2％ vs 0,respectively,x2 =56.32,23.18,all P ＜ 0.01).Conclusion The domestic ADV superior to matrine in HBeAg-positive patients.

Biliary-pancreatic-duodenal junction is a special region in the human body.It is difficult to diagnose and treat diseases in this region because of the complicated anatomy,the limitation of diagnosing methods,the variety of disease,the high risks of operation and the severity of complications. We should pay more attention to the pathophysiology aspects and the laboratory researches of diseases in this region.Proper diagnosis and combination of different diagnosing methods could improve the rate of early diagnosis and identify the characteristics of the disease. Individualized operation should be considered to deal with iatrogenic injury of biliary-pancreatic-duodenal junction according to different patients' condition.The principle of operation is to control damage firstly and to preserve the function of biliary-pancreatic-duodenal junction and the physiological passway of bile and pancreatic juice to the greatest extent.

ObjectiveTo evaluate the clinical efficacy and toxicity of the regimen of paclitaxel combined with gemcitabine for anthracycine-resistant metastatic breast cancer. MethodsThirty patients with anthracycine-resistant metastatic breast cancer were enrolled in the study: paclitaxel 135mg/m2 infusion on day 1; Gemcitabine 850mg/m2 infusion on day 1,8 ,and administered in three weeks cycle. The clinical efficacy was evaluated every two cycles. ResultsOf all thirty patients qualified for efficacy analysis and among them CR 3 cases( 10％ ) ,PR 11 cases (36.7 ％ ), SD 11 cases ( 36.7％ ), and PD 5 cases ( 16.7％ ), with an overall response rate of 46.7％. The median TTP and overall survival in those 30 patients was 7.1 and 15.6 months. The main toxicities with grade 3 and 4 were hypoleucocytosis in 10 patients(30.0％ ) ,thrombocytopenia in 4 patients( 13.3％ ). ConclusionThe regimen of paclitaxel combined with gemcitabine was effective,well-tolerated scheme in the anthracycine-resistant metastatic breast cancer.

OBJECTIVE: To investigate the protective immunity in mice immunized with rEg.EF-1 and its potential as vaccine candidate.METHODS: ICR mice were subcutaneously immunized with rEg.EF-1 for three times(with an interval of 2 weeks) and challenged with Eg 2 weeks after the completion the immunization,sacrificed at 20 weeks after infection with Eg.The rate of reduced hydatid cyst and the levels of IgE,IgG and IgG subclasses in sera were examined by enzyme linked immunosorbent assay,with adjuvant group as control.RESULTS: As compared with adjuvant group,the immunoprotection ability(rate of reduced hydatid cyst) in rEg.EF-1 group was 85.6%;The levels of IgG,IgG1 and IgG2a in mice immunized with rEg.EF-1 significantly increased(P0.05),and no significant difference was noted in IgG3 and IgE levels.CONCLUSIONS: The rEg.EF-1 antigen could induce certain immunoprotection,suggesting the potential of rEg.EF-1 as an vaccine candidate.

Hepatitis B associated with glomerulonephritis (HB-GN) has been increasing year after yea-r Tehispaper reports 24 cases of HE-GN treated between 1979 and 1984 whose clinical manifesta tion(?)the laboratory data confirmed the diagnosis. Our observations show that HB is mor often associated with extrahepatic lesions, sometimes appearing as the initial disorder or syndrome, including glomerulonephritis, carditis, arthritins, gastrocntentis and/or serum sickness, etc. HB-GN is also a kind of immune complex GN, whose pathogenesis is usually associatede with chronic active hepatitis, especially a decrease in the immune function of the Patient. Complex treatment, including liver Protection and immune stimulant treatment (blood and/or Plasma transfusion, thymosin, or levamisole)could give a better therapeutic effect.

OBJECTIVE: To remind the concerned party of the importance of safe and rational use of drugs and the reevaluation of drugs after they have been put into market. METHODS: To analyze the occurring process and the treatment of six death/disability cases related to adverse drug reactions in Ningxia area as well as the problems existed in the management on safe drug use and the solutions. RESULTS & CONCLUSIONS: Management on safe drug use should be reinforced within the system of health and drug administration, and great importance should be attached to the reevaluation of drugs after they have been put into market to ensure safe and rational drug use.

Aim To explore the antitumor active metabolites of marine-derived Streptomyces flavorectus Z4-007. Methods The separation procedure was guided by a flow cytometric bioassay using tsFT210 cells to examine cell cycle inhibitory activity, and various column chromatography using silica gel, Sephadex LH-20, and ODS were employed for the isolation and purification of bioactive compounds. Chemical structures were investigated by spectroscopic methods and biological activities were evaluated by flow cytometry using mouse cancer tsFT210 cells. Results Four bioactive compounds were isolated from the fermentation broth of Streptomyces flavorectus Z4-007, one of them had been identified as 1-(2,4-Dihydroxy-3,5-dimethyl-phenyl)-hexa- (E,E)-2,4-dien-1-one (1) and the other three compounds were considered to be peptide, Compound Ⅰ inhibited the cell-cycle of tsFT210 cells at the G_0/G_1 phase at higher concentrations, while at the lower concentrations compound Ⅰ inhibited the cell-cycle mainly at the G_2/M phase, accompanied with induction of apoptosis in the tsFT210 cells.Conclusion Compound Ⅰ was isolated from the metabolites of the genus Streptomyces for the first time and provided as a new cell-cycle inhibitor.

Objective:To assess clinical value of grading scale for intracerebral hemorrhage(ICH).Methods:By using the grading scale for ICH suggested by Hemphill and colleagues, 205 patients with acute ICH presenting to our department during 2000～2001 were studied retrospectively.Results:Thirty-mortality of ICH patient increased steadily with ICH Score.Conclusion:The grading scale for ICH is a simple amd reliable method of ICH score,worthy of clinical application.