Based on the dynamic performance of radial force sensor detection and TCM pulse waveform technology, the paper described a kind of testing equipment being developed which tests both radial force sensor performance and the dynamic performance of the instrument of pulse detection. The device covers requirements for static and dynamic performance test of the radial artery pulse wave force sensor and pulse diagnosis instrument, thus it makes a change to compute frequency response of the sensor by directly measurement.
Equipment Design ; Humans ; Pulse ; Radial Artery ; Transducers

Since the tumor necrosis factor-related apoptosis-inducing ligand was found as a suitable agent for anticancer therapies,study on tumor research has been attaching more importance to it.Utilized the progress on the study of TRAIL on pancreatic carcinoma aspect recent years and standed the principle in TRAIL inducing pancreatic carcinoma apoptosis,this article first simply reviewed the resistance theory of TRAIL on pancreatic carcinoma.Following the trail of identified resistance theory,carring the method of increasing TRAIL's sensibility with protein inhibition,signal regulation,ect,some new treatments have been received,which are described along with the antitumor effect of TRAIL combined with mature treatment in pancreatic carcinoma,and simply assessed at last in the article,to provide a reference on the synergistic cytotoxic effects of TRAIL combined with valid drugs on panreatic carcinoma.

Tumor cell invasion and metastasis are associated with the proteolytic activity of various types of proteinases.Among them,cathepsin D,which is a lysosomal proteinase,has received more attention recently.Various studies have shown that the lysosomal aspartic protease cathepsin D is over-expressed and hyper-secreted by numerous cancer cell lines.Indeed it plays an essential role in the multiple steps of tumor progression,in stimulating cancer cell proliferation,tumor invasion and metastasis,fibroblast outgrowth and angiogenesis,as well as in inhibiting tumor apoptosis.In addition,CD is also a key mediator of induced- apoptosis.The aim of this article is to review the current knowledge on Cathepsin D action in cancer progression and metastasis,as well as its dual function in apoptosis.

Abodominal giant incisional hernia is the common complication of abdominal operations,and surgery is the only efficient treatment for it.It is important to treat the local complications,to use antibiotics and to assess the tolerance of increased intra-abdominal pressure before operation.Component separation technique is feasible to close the abdominal wall defect,which is one of the main difficuhies in giant heruia repair.After that,mesh repair with biological materials is recommended to enhance the abdominal wall.Although mesh repair techniques diversified,sandwich hernionhaphy seems superior.This paper will analyse the present treatment progress of abdominal giant incisional hernia.

With the progress of minimally invasive surgical techniques,the vast majority of general surgery can be safely carried out laparoscopically.But the development of the pancreas laparoscopic surgery is lagging behind.Initially laparoscopy was used only as a diagnostic and staging tool.Nevertheless with more and more successful launch of laparoscopic surgery.Surgeons devoted a great deal of energy to this field in order to benefit more patients.This review focused on the literature of laparoscopic pancreatic surgery in resent years,although the majority of literature suggests that the minimally invasive pancreatic surgery has advantages of rapid recovery,low complication rate compared to traditional open surgery.However,most studies are limited to a small sample and a single institution results.The promotion of this emerging technology still needs more rigorous evidence based medicine.

Objective:To investigate the protective effects of matrine(MT) preconditioning against hepatic ischemia-reperfusion injury in rats. Methods:Fifty male SD rats were randomly allocated into 5 groups:sham operation(SO) group,ischemia-reperfusion (NS) group and MT preconditioning groups (of 3.75,7.5,15 mg/kg). Rats of NS and MT groups were injected normal saline or MT,respectively; and 15 min later,the pedicales of the left and median liver lobes were clampped for 45 minutes,and reperfused for 40 min. The portal trial were only separated but not obstructed in SO rats. After reperfusion,the serum activity of ALT,AST and LDH was determined,the activity of SOD and content of MDA in liver tissue were examined,and histopathological changes of liver were observed. Results:Compared with those of NS group,the serum levels of ALT,AST,LDH,and the content of MDA in liver tissue of MT groups were lower,and the activity of SOD was higher(P

The tumor microenvironment is a special environment including tumor cells,stromal cells and extracellular matrix.The notion that the tumor microenvironment is a necessary functional unit to support cancer progression,metastasis and recurrence has been accepted by more and more scholars.Studies have shown that exosomes may play a pivotal role in tumor progression that involved in cell-cell communication in the tumor microenvironment.Here,we summarize the recent publications on the characteristics of exosomes,its biological effects and the potential roles as an important part of the tumor microenvironment during tumor progression.

Drug delivery system in tumor targeting research has always been a difficult problem.Apoptosis in vitro experiments and body pharmacokinetic experiments can not reflect the targeting of drug delivery system indirectly.Imaging techniques both in vivo and in vitro solve the problem,researchers can not only observe the drug delivery system in the target organ,the target tissue and target cell directly,but also analyze quantitatively and qualitatively.

Researching tissue engineered biliary duct aims to repair,replace and regenerate damaged or diseased bile duct by using the in vitro constructed tissues.In this article,we reviewed the cell sources,and scaffolds and the current status of the construction of the tissue engineered biliary duct in tissue engineering.and discussed the existing obstacles and development trends.Tissue engineered biliary duct has an intriguing perspective for the replacement therapy,but it is still at an early stage,its true value remains to be evaluated.

Parathyroid scanning was performed with 99mTc-MIBI in 10 patients who had clinical and biochemical findings suggesting primary hyperparathyroidism but had no enlarged parathyroid or palpable thyroid. Seven cases were scanned with both 99mTc-MIBI and 99mTc and three cases with 99mTc-MIBI only but perchlorate was administered during the scan. A series of images were acquired for all cases at different time intervals after 99mTc-MIBI was injected intravenously to allow the dynamic studies. The P/T ratios (counts in parathyroid counts in thyroid)were also designed to see whether the agent had different uptakes and metabolic characteristics in parathyroid and thyroid tissues from 99mTc-MIBI. Surgical finding and histological examination were taken as gold standard against which US. CT and scintigraphy were judged. Finally, 10 adenomas found exactly at the sites predicted by scintigraphy and 2 hyperplastic glands were removed from the 10 patients. Ten of 10 99mTc-MIBI scans, two of 9 US scans and three of 8 CT scans were positive for a parathyroid adenoma, but 2 hyperplastic glands were missed by all of the three methods. It was shown that the suitable time for imaging was at 1h-2h or 30min-1h(if perchlorate was used) after 99mTc-MIBI was given, so as to render both adenoma and background clear. Despite the limited number of cases, the preliminary experience thus suggests that 99mTc-MIBI scintigraphy maybecome the technique of choice for the localization of hyperparathyroidism in stead of 21Tl.