Objective To evaluate the prognosis of recurrent laryngeal cancer after surgieat treatment, the study was designed to investigate the relationship of VEGF and Cath-D expression in patients with recurrent laryngeal carcinoma. Methods Five hundred and seventy-four cases of laryngeal carcinoma treated in our department from 1958 to 1999 were retrospectively reviewed. All patients were observed for 3 years postoperatively. The whole set of tissue microarrays prepared with tumor tissue from 574 patients, including recurrent tumor tissue from 56 patients, and also 39 normal laryngeal tissue from normal subjects. The tissue chips were analyzed by the SABC immunohistochemical method. Results VEGF and Cath-D were expressed in most of the laryngeal carcinoma and normal laryngeal tissue, but the positive ratio of them was different. There was higher expression of VEGF and Cath-D in recurrent laryngeal carcinoma compared with that in laryngeal carcinoma without recurrence and normal laryngeal tissue (P

Objective To evaluate the prognosis of laryngeal cancer in terms of postoperative recurrence,the study was designed to investigate the relationship of E-cadherin,CD44,and Tenascin expression in patients with recurrent laryngeal carcinoma. Methods 574 cases of laryngeal carcinoma treated in our department from 1958 to 1999 were retrospectively reviewed. All patients were observed for 3 years postoperatively. The whole set of tissue microarray contained tumor tissue from all these patients,including recurrent tumor tissue from 56 patients,39 normal laryngeal tissue from normal larynx. The tissue chips were analyzed by the SABC immunohistochemical method. Results E-cadherin,CD44,and Tenascin were expressed in most of the laryngeal carcinoma and normal laryngeal tissue,but the positive ratio was different. There was lower expression of E-cadherin in recurrent laryngeal carcinoma compared to that in laryngeal carcinoma without recurrence,and the difference was statistically significant ( P

Objective To investigate the species and distribution of Mussaenda L. in Guangxi, and provide basis for protecting, developing and utilizing the local plant resources. Methods By field survey, specimens collection and identification and literatures consultion, Mussaenda L. in Guangxi was investigated. Results Mussaenda L. in Guangxi contains 8 species, and the majority of them are Mussaenda pubescens Ait.f and Mussaenda eros Champ. Conclusion The investigation results provide some basis for protection, development and utilization of the resources of Mussaenda L. in Guangxi.

EEG feedback therapy has some value in mental disease treatment. This article designs an EEG feedback system with complete function and good performance based on virtual instruments technology, and brings out project of hardware and software to develop the system. Prototype of the system is made and has some effect of clinic application in mental disease?

Objective To investigate clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinoma (MPCC). Methods A retrospective analysis was made on 37 patients with MPCC admitted from 1974 to 1998. ResultsThe incidence of MPCC was 2 74%(37/1 348) with 15 cases being synchronous carcinoma (SC) and 22 cases diagnosed as metachronous carcinomas (MC). Most tumors were located in right colon and rectum. Twelve out of twenty-two (55%) of MC were diagnosed within 3 years from the primary operation and 41% (9/22) of MC occurred after 8 years. JP2Radical resections were performed in all patients except for 1 case. The 5 year survival rate of SC was 5/9 and that of MC after the first cancer or second cancer were 15/21 and 7/18, respectively. Conclusions The results indicated the importance of complete preoperative examination, careful intraoperative exploration and periodic postoperative surveillance. Early diagnosis and active radical resection can increase survival rate of MPCC.

Objective:To explore the functional mechanism of moxibustion and its enlightenment to the design and manufacture of moxibustion apparatus.Methods:The functional mechanism of moxibustion is explored from its pharmaceutical properties,warming stimulation,spectrum,radiation features,and penetrating effects of moxa products.Result:The mechanism of moxibustion is a combined action of moxa'medicinal properties,warming effect and non-thermal effect.Conclusion:It is necessary to combine with the functional mechanism to design and manufacture moxibustion apparatus.

【Objective】 To retrospectively analyze the clinical effects of apheresis and concentrated platelets under different transfusion strategies, so as to explore more scientific transfusion strategies. 【Methods】 A total of 279 patients with thrombocytopenia, admitted to our hospital during January 2020 and October 2021, were collected.They was divided into group A(apheresis platelet transfusion alone), group B(concentrated platelet transfusion alone), and group C(both apheresis and concentrated platelet transfusion). Platelet count of three groups were measured 24 hours before and after transfusion and their CCI values were calculated and compared to understand the differences in transfusion efficiency and adverse reactions, as well as the efficacy among three groups with different blood groups. 【Results】 Patients, received solo apheresis platelets, demonstrated a lower incidence of transfusion refractoriness and adverse reactions, but also a lower treatment efficacy(14.63±13.48)(P<0.05). However, the treatment efficacy of patients, received solo concentrated apheresis, could reach 16.00±21.77, but presented a higher incidence of transfusion refractoriness and adverse reactions. Patients, received both apheresis and concentrated platelets, maintained a good treatment efficacy(16.21±16.33), with a low incidence of transfusion refractoriness and adverse reactions.At the same time, different blood types also affect the treatment efficacy of platelet transfusion. 【Conclusion】 The simultaneous transfusion of apheresis and concentrated platelets contributes to the effective treatment of patients and lower incidence of adverse reactions.

Objective To investigate the correlation between the levels of Hcy ,VitB12 and folic acid with Alzheimer′s Disease(AD) .Methods Fifty-four patients with AD in this hospital were extracted as the AD group by using cluster sampling method ,and contemporaneous 50 persons undergoing healthy physical exami-nation were selected as the control group .The levels of serum Hcy ,VitB12 and folic acid were detected in the two groups .Then the correlation among 3 indicators was analyzed .Results Compared with the control group , the level of serum Hcy in the AD group was significantly increased (P<0 .05) ,the VitB12 and folic acid levels in the AD group were significantly decreased compared with the control group (P<0 .05) .The serum Hcy lev-el was negatively correlated with VitB12 and folic acid levels (r= -0 .751 ,-0 .807 ,P<0 .05) .The area under the receiver operating characteristic curves (AUC) of Hcy ,VitB12 and folic acid and their combine detection in AD patients were 0 .897 ,0 .176 ,0 .204 and 0 .933 respectively .Conclusion Serum Hcy ,VitB12 and folic acid have clinical diagnosis value in AD ,and the 3-indicator combined detection can increase the diagnosis efficiency .

【Objective】 To retrospectively analyze the guiding significance and effect of thromboelogram (TEG) in the clinical use of cryoprecipitation. 【Methods】 A total of 289 patients with fibrinogen reduction, admitted to our hospital between January 2018 and December 2021, were collected. They was divided into control group (using coagulation examination and clinical feature as the transfusion criteria) and observation group (above parameters plus TEG). The TEG index in the observation group before and after transfusion and Fg, APTT, PT, and TT in 2 groups of patients before and after transfusion were monitored. The efficacy and prognosis of different blood products and cryoprecipitate were compared between 2 groups of patients.) 【Results】 The efficacy of choprecipitate transfusion was better in the observation group than the control[Fg index after transfusion (g / L) 1.92±0.92 vs 1.80±1.00, P<0.05]. And less blood products were used in observation group as compared with the control[ RBC(U) 1.93±2.69 vs 2.81±3.25 (P<0.05); FFP(mL) 667±378 vs 879±455(P<0.05)]. No differences were noticed by hospital stay between the two groups, but the prognosis in the observed group was significantly better than that in the control. 【Conclusion】 It’s scientific and reasonable to apply TEG to guide the clinical transfusion of cryoprecipitate, so as to save blood resources and improve the prognosis.

With the approaches of artificial intelligence and big data, the development of cancer genomics and updating of imaging technology, gastric cancer surgery is facing great challenges and opportunities. The main focus is on laparoscopic surgery technology, enhanced recovery after surgery, multidisciplinary comprehensive treatment, and precision medicine. Considering the common de-mand for reduced complication rate among doctors and patients, laparoscopic surgery has become widely popular owing to its advan-tages of small incision and rapid recovery. Furthermore, the development of artificial intelligence and big data has raised a new chal-lenge in routine diagnosis and treatment. As a result, we encourage multicenter cooperation, and data standardization and sharing. At present, completion of the transition from empirical medicine to evidence-based medicine and promotion of the individualization and standardization of gastric cancer treatment are needed.