Objective To survey on the graduate students about their own requirements, the guid-ance of tutors and the compliance, and put the gists for the educators and administrators. Methods Using the comprehensive questionnaires including Eugenie Creativity Test and Motivation Scale, the investigation surveyed on 900 graduate students in a medical university about their requirements and tutors' concerned aspects in their opinions, which was whether influenced by Intelligence (creativity), the Non-Intelligence factors (motivation) or not. Epidata 3.1 was used to input data of the investigation, and SPSS 16.0 statistical software was used to analyze it. The items were set as multiple-choices, and the percent of responses was used. Results The students thought the tutors' concerned aspects were mainly creative thinking [61.1%(1129/1847)], research methods [58.2%(1075/1847), specialty knowledge [41.8%(772/1847)], scientific spirit
[35.4%(654/1847)], academic morality [24.3%(516/2124)] and book knowledge [5.4%(100/1847) ], while the graduate students paid more attention to its research methods [72.4%(1538/2124)], innovative thinking [64.0%(1359/2124), professional knowledge [60.0%(1274/2124)], the spirit of science [33.9%(720/2124)], academic morality [24.3%(516/2124)] and book knowledge [10.0%(212/2124)]. The percentages of research methods and specialty knowledge concerned by most of the students were higher than those tutors' con-cerned in the students' opinion. The percentages of specialty knowledge concerned by the students with high innovation and motivation were 56.2%(443/789) and 58%(345/595), which were higher than those concerned by the tutors 38.5%(255/662) and 29.4%(148/503). Conclusion In the students' opinion, tutors concerned more creative thinking, the students concerned more research methods, while they concerned similarly in the other aspects. For the students, the guidance of the tutors cannot still meet their study demands, espe-cially in research methods and specialty knowledge. Those with different motivations and innovations have different study requirements.

Objective To analyze the viewpoints of the graduate students on the effective ap-proaches in cultivating their innovations. Methods Using Eugenie Creativity Test scale and self-made questionnalre, the graduate students in a medical university were surveyed on their general informa-tion, innovation levels and viewpoints of the important links and effective approaches in cultivating the innovations. The statistical software package-SPSS 16.0 was used for questionnalres. The statistical analysis was based on chi-square test for categorical data in the levels of graduate students' innovation and variance analysis for quantitative data in graduate students' understanding of the importance of cultivating approaches. Results 1 000 questionnalres were given out and effective questionnalre 936 copies were collected. The innovations of the students were malnly medium (557/936, 59.6%) and strong (356/936, 38.0%). They thought research and practice were the most important (F=225.49, P=0.00) in the tralning links and strengthening the tutorial staff was the foremost in the cultivating ap-proaches, which was followed by the sorted tralning (F=50.36, P=0.00). Conclusion The views of the graduate students on the cultivation jobs should be pald attention to. According to this study results, the management of research and practice, tutorial staff and assorted tralning should be fully considered to advance their innovations.

Objective To discuss the clinical value of the suture of sacral ligament and pubovaginalis fascia plus sacrospinous ligament fixation in the treatment of moderate and severe pelvic organ prolapse ( POP) . Methods Thirty-two cases with moderate or severe POP,who were treated by the suture of sacral ligament and pubovaginalis fascia besides sacrospinous ligament fixation,were retrospectively analyzed. Results The locations of POP in the 32 patients were mainly in the anterior and middle pelvis cavity. The degree of uterine prolapse was not less than POP-Q Ⅲ phase. The anterior and/or posterior vaginal walls were also prolapsed. The patients were treated by the transvaginal panhysterectomy,vaginal wall neoplasty,sacrospinous ligament fixation and the suture of sacral ligament and pubovaginalis fascia. Those with stress incontinence were also treated with urethral posterior ligament plication. The operation time was 60~120 min,and the hemorrhage vol-ume was 100~300 mL. There were no severe complications or recurrence in all patients. Conclusion The suture of sacral ligament and pubovaginalis fascia could greatly reduce the hazard rate of the recurrence of anterior pelvic organ defects in POP patients treated by sacrospi-nous ligament fixation. The suture operation could strengthen the anterior pelvis cavity,and was proven to be simple,secure and effective. Therefore,the operation is valuable to be used in clinical application.

Objective To analyse effects of the serum levels of thyroid peroxidase antibodies (TPOAb) on antithyroid drugs (ATD) treatment in patients with incipient Graves disease (GD). Methods A total of 121 patients with incipient GD, who were used anti thyroid drugs for 12 months, were included in this study. Patients were dvided into two groups:TPOAb negative group (TPOAb≤35 IU/mL, n=49) and TPOAb positive group (TPOAb>35 IU/mL, n=72). According to the degree of TPOAb drops the TPOAb positive group was sub-divided into low level positive group (35 IU/mL1 000 IU/mL, n=20). The ATD total dosage for 12 months and thyroid-stimulating hormone (TSH), which returned to normal rate after treatment of 3, 6 and 12 months, were compared between groups. Results ATD total dose was lower in TPOAb positive group (1 743.82±265.38) mg than that of negative group (1 889.18 ±125.51) mg. The ATD total dosages were (1 759.71±230.29) mg, (1 793.75±299.02) mg, (1 731.54± 236.44) mg and (1 710.00 ± 290.73) mg for low level TPOAb positive group, medium level TPOAb positive group, high level TPOAb positive group, and very high level TPOAb positive group respectively. The recovering ratio of TSH was significantly higher in TPOAb positive group than that of TPOAb negative group after 3-month treatment (P<0.05). Conclusion TPOAb positive serum can lead to shorten the course of ATD treatment and reduce the total amount of ATD treatment in GD patients.

AIM: To investigate the effect of PMA(phorbol 12-myristate 13-acetate) on the expression of CD18 and the mechanism. METHODS: The technique of quantitative RT-PCR analysis was used to measure the expression of CD18 mRNA in U937 cells treated by PMA. RESULTS: PMA could significantly induce CD18 mRNA expression in a dose and time-dependent manner. The induction effects of PMA on CD18 mRNA could be inhibited obviously by Myr (2 ?mol/L), a specific inhibitor of PKC, and APDC, an inhibitor of NF-?B, but not be inhibited by curcumin, a inhibitor of transcriptional factor AP-1. CONCLUSION: PMA enhanced the expression of CD18 via the pathway of PKC. Transcriptional factor NF-?B, but not AP-1, was essential for the gene transcription of CD18 in U937 cells treated by PMA.

Analyzing and discriminating incorrect cases is a good method in medical statistics teaching,which can not only help students review the knowledge they have learned but also guide their self-learning.Teachers can start teaching based on the reverse thinking,propose incorrect cases with moderate difficulty and in accordance with the reality and arouse students' creativity through introducing the incorrect cases,reviewing the incorrect cases and conducting group discussion.

Objective: Extracting ephedrine and berberine from the water extract of Ephedra Herba and Rhizoma Coptidis. Methods: Modified PVA was used as separating membrane and separated alkaloids. Results: A colorless ephedrine aqueous solution was obtained when extraction time was less than 8 hours; while a three constitution solution was obtained when time of extraction is over 8 hours. So is Rhizoma Coptidis. The membrane is hardly fouled. Conclusion: Purity of alkaloids from Herba Ephedra and Rhizoma Coptidis by membrane separation is Superior to that by alcoholic sediment but amount of alkaloids is reverse.

In order to improve the scientific research capability of medical graduates,help them cultivate scientific statistical mind and the ability to resolve actual medical scientific research issues,we made a teaching reform on the teaching objectives,curriculum system,teaching material and informational teaching of Medical Statistics teaching,established a diversified teaching pattern and improved the teaching quality.

Objective:To evaluate the quality status of lithium carbonate tablets and lithium carbonate sustained-release tablets. Methods:The samples were examined in accordance with the statutory standard,and the exploratory studies were carried out. The results were statistically analyzed. Results:In accordance with the statutory standard,among 120 batches of samples, only one was unqualified in dissolution,and the others were qualified. The qualified rate was 99. 2% . Conclusion:The quality of the most products meets the current standard and the quality evaluation standard needs to be improved.

AIM: To study the effect of dexamethasone(Dex) on the expression of CD18. METHODS: Quantitative RT-PCR analysis, Northern blotting technique were used to measure the expression of CD18 in U937 cells treated by PMA. RESULTS : Dex could significantly attenuated the effects of PMA in a dose-dependent manner (10 -6 mol/L-10 -10 mol/L). These effects of Dex (10 -7 mol/L) were completely aborted by RU-486 (10 -6 mol/L).CONCLUSION: Dex, via GR, could inhibit CD18 mRNA expression in U937 cells treated by PMA. The effects of Dex might be possibly depended on the counteracting action on the NF-?B.