In the past few decades, accumulated experimental and clinical evidences suggest that cyclic guanosine monophos-phate (cGMP) plays an important role in atheroselerosis. Vasodilator-stimulated phosphoprotein (VASP), a major downstream compo-nent of the cGMP signaling cascade, is an actin-binding protein which regulates cell adhesion, morphology change, cell motility and cell proliferation. It has shown that VASP is associated with many factors influencing atherosclerosis, and it plays an important role in the genesis and development of atherosclerosis. The relationships between the occurrence of atherosclerosis and risk factors for athero-sclerosis such as hypertension, hyperglycaemia and hyperlipidemia are reviewed in this article.

Objective:To study the application of partial least squares (PLS) in spectrophotometry,and to simultaneously determine four synthetic food colors with PLS.Methods:? max for Tartrazine,sunset yellow,ponocean 4R and amaranth were 428?2nm,482?2nm,508?2nm,520?2nm respectively,which revealed significant overlapping of simultaneous determination of mixture of four synthetic food colors by spectrophotometry,whithout any preliminary chemical separation.Results:The mean recoveries and relative standard deviation(RSD) for each sample were 100.6%,100.5%,99.5%,101.1% and 1.28%,1.11%,1.01%,1.96%,respectively.The actual results of two kinds of samples were also satisfactory.Conclusion:The patial least squares may provide a new approach to determination of the content from multi-component spectroscpic data whithout any preliminary chemical separation.

Objective To evaluate the effiicacy of nasotracheal intubation using blind tracheal intubation device and end-tidal carbon dioxide monitoring technique in patients with difficult airway.Methods Sixty ASA Ⅰ or Ⅱ patients of both sexes,aged 35-60 yr,weighing 55-75 kg,requiring nasotracheal intubation,undergoing selective oral and maxillofacial surgery,were involoved in this study.All of them were expected to have difficuh airway such as mouth opening ＜ 3 cm,neck upward degree ＜ 30° and Mallampati classification Ⅲ or Ⅳ,The patients were randomly divided into 2 groups(n =30):group Ⅰ received tracheal intubation with the blind tracheal intubation device and group H received tracheal intubation with the blind intubation device combined with end-tidal carbon dioxide monitoring technique.The number of successful intubation,the inlubation time and adverse effects during intubation(epistaxis,tachycardia,hypertension and hypoxemia)and after operation(sore throat and hoarseness)were recorded.Results The rate of successful intubation in the two groups was 100％.Tachycardia,hypertension,hypoxemia and hoarseness were not found in the two groups.Compared with group I,the rate of successful intubation at first attempt was significantly increased,the intubation time was significantly shortened,and the incidence of epistaxis and sore throat was decreased in group Ⅱ(P ＜ 0.05).Conclusion The blind intubation device combined with end-tidal carbon dioxide monitoring technique used in diffficult airway can shorten the intubation time,increase the success rate of tracheal intubation,and decrease the occurrence of adverse effects.

Objective:To investigate the impact of butylphthalide on homocysteine, CRP and nerve function in the patients with a-cute progressive cerebral infarction. Methods:Totally 122 cases of patients with acute cerebral infarction were randomly divided into the observation group (n=60) and the control group (n=62). The control group was treated with the routine treatment, and the ob-servation group was treated with butylphthalide additionally. The treatment course was two weeks. The total effective rate, blood Hcy, the level of plasma CRP and the changes of neurological function deficits scale in both groups before and after the treatment were ob-served and compared. Results:The overall response rate in the observation group (81. 67%) was significantly higher than that in the control group (64. 52%). After the treatment, the blood Hcy and CRP in both groups were significantly lower than that before the treatment(P<0. 05), and that of the observation group was significantly lower than that of the control group(P<0. 05). The neuro-logical function deficits scale in both groups were significantly lower than that before the treatment(P<0. 05), and that of the observa-tion group was significantly lower than that of the control group at the same period. The two groups during the treatment showed no sig-nificant adverse reactions. Conclusion: The effect of butylphthalide in the patients with acute cerebral infarction is effective, which can reduce blood Hcy, the level of plasma CRP and the neurological function deficits scale, and improve the neurological function with-out obvious adverse reactions during the treatment course.

Objective To analyze the value of carbon nanoparticles in the cleaning of thyroid cancer lymph node.Methods 80 patients with thyroid cancer from March 2012 to March 2013 were included in this study.Based on the sequence of enrollment,they were randomly divided into two groups:the therapy group (n=40)were received Nano carbon lymphatic tracer before basic operative treatment and the control group (n=40)were directly received the same basic operative treatment.The liver function parameters in two groups were observed and compared statistically. Results The operating time,operative blood loss and postoperative drainage volume had no statistically significant difference between two groups.The incidence of postoperative hypocalcemia in experimental group was lower than that in blank control group(P<0.05 ).The parathyroid hormone level in experimental group on the first postoperative day was higher than that in blank control group(P<0.05 ).The number of resected lymph nodes in experimental group was more than that in blank control group(P<0.01).Conclusion Nano carbon lymphatic tracer technique can increase the cleaning number of lymph node of thyroid cancer patients in central region,and realize the accurating tumor stage.

Objective Through analysis the amount and the types for the bacterial in the conjunctival sac between the warm meibomian gland massage and routine preoperative preparation for the inner eye operations,to compare the bacterial state before and after the nursing intervention,as to analysis of preoperative administration of the routine preoperative preparation on the effectiveness of prevention of postoperative intraocular inflammation,and so on peri operation period nursing intervention is effective in reducing or preventing endophthalmitis.Methods 40 patients(40 eyes) undergoing eye operation during March to December of 2013 in our hospital,they were divided into the experimental group and the control group,with preoperative warm meibomian gland massage the experimental group based in the implementation of internal eye operation on routine preparation.Based on all the patients in group (V1),on the morning of surgery (V2) before operation,after disinfection(V3),before the end of operation(V4),after the next morning(V5) and after 1 weeks of operation (V6) of the 5 conjunctival sac sampling cultured conjunctival sac fungi and bacteria population analysis.Results Two groups of cultured conjunctival sac and there were significant differences between the V1 and V6 for both groups in the amount and the tapes of the bacterial.Conclusions The inner eye operation patients with warm meibomian gland massage can effectively reduce or inhibit the bacterial amount after operation in the conjunctival sac,effectively reduce the occurrence of postoperative endophthalmitis of hidden dangers,this procedure should be schduled in the standerand SOP for the peri--operative preparation for the inner eye operations.

Background Glaucoma is a kind of psychosomatic disorder.Investigating the psychological and behavioral characteristics of glaucoma patients has important implication for the prevention and treatment of the disease.Objective Present study aimed to characterize the personality profile of initial diagnosed glaucomatous patients.Methods Eighty-seven patients with primary open angle glaucoma (POAG),ninety-two patients with primary angle-closure glaucoma (PACG) and eighty-nine normal controls (normal control group) were enrolled in this study from January 2008 to May 2014 in Peking University People 's Hospital.Clinical and demographic information which could relate to personality type was collected by filling in Symptom Checklist 90 (SCL-90),Life Event Scale (LES),Eysenck Personality Questionnaire (EPQ),Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) voluntarily under the informed consent.The psychological,personality and behavior characteristics of the individuals were analyzed and compared among the different populations.Results In SCL-90,the scores of compulsivity,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation and psychoticism inpatients with primary glaucoma were significant different among the three groups (all at P＜0.01),and the scores were significantly higher in the patients of the POAG group and PACG group than those in the normal control group,and the scores were increased in the PACG group compared with the POAG group (all at P＜0.05).In LES,the scores of family events,social intercourse and other events,life events,stress response were significantly different among the three groups (P =0.032,0.002,0.001,0.000),and these scores were significant higher in the POAG group and PACG group compared with the normal control group,and the PACG group also had a significantly greater frequency of clinically abnormal score than the POAG group (all at P＜0.05).EPQ data showed that the scores of psychology and nervousness in the POAG group and the PACG group were higher than those in the normal control group (all at P＜0.05),but no significant difference were found in extroversion and stability of the personality among the three groups (P=0.321,0.315).The total scores of SAS and SDS were considerably higher in the POAG group and the PACG group compared with the normal control group or the PACG group compared with the POAG group (all at P＜0.05).The incidences of anxiety and depression were elevated in the POAG group and the PACG group in comparison with the normal control group (x2 =15.520,P =0.000 ; x2 =14.870,P =0.000).Conclusions The personality and behavioral factors are associated with the pathogenesis,development and therapy of primary glaucoma.The anxiety,depression and stronger stress response are found in glaucoma patients,especially PACG patients.

The paper analyzes the challenge of big data environment to the traditional medical information services,presents the practical significance and basis of constructing the medical information service platform,introduces the construction objectives,architecture,function feature of the platform,describes the medical information service mode based on the digital platform,including medical information resource services,intelligence study services and health decision-making support services,etc.