OBJECTIVE:To compare antidiuretic activity of Ootheca Mantidis before and after processing,and to explore the best medicinal part and mechanism of Ootheca Mantidis. METHODS:96 rats were randomly divided into blank group,model group,positive group,Ootheca Mantidis group,Ootheca Mantidis stir-fried with salt group,steamed Ootheca Mantidis group, crude product eggs and egg shell groups,processed product eggs and egg shell groups,with 8 rats in each group,12 groups in to-tal. Except blank group,other groups were given adenine 250 mg/kg,ig,for 4 weeks to induce kidney-yang and diuresis model. From third week,Ootheca Mantidis crude drug group and processed Ootheca Mantidis group were all given relevant medicine 0.11 g(crude drug)/ml i.g,and crude product eggs and egg shell groups and processed product eggs and egg shell groups were given rel-evant medicine,ig,once a day,by mass ratio of eggs to egg shell(cude drug 1∶2.4,salt stir-fried product 1∶1.7,steamed prod-uct 1∶2.1)for consecutive 4 weeks. The urinary volume,body weight,renal index and the serum contents of ADH and ALD were all determined. RESULTS:Compared with blank group,body weight and serum content of ADH and ALD decreased in model group,while renal index and urinary volume increased(P<0.05). After 4 weeks of treatment,compared with model group,body weight and serum content of ADH increased in Ootheca Mantidis groups,while urinary volume and renal index decreased (P<0.05);serum content of ALD increased in treatment groups;there was statistical significance in the serum content of ALD in those groups except Ootheca Mantidis group,Ootheca Mantidis stir-fried with salt group and steamed Ootheca Mantidis group (P<0.05);except for ALD,those index were in descending order of steamed Ootheca Mantidis group>Ootheca Mantidis stir-fried with salt group>Ootheca Mantidis group,and steamed Ootheca Mantidis shell group had best exchange. CONCLUSIONS:The an-tidiuretic activity of Ootheca Mantidis has been enhanced after processing. The egg shell of steamed Ootheca Mantidis is main me-dicinal part. To increase the serum content of ADH might be one of the main mechanism of arresting polyuria.

ObjectiveTo observe the changes in plasma interleukin-33 (IL-33) in patients with sepsis and its regularity, the association between IL-33 and the infection, and the significance of IL-33 in predicting the prognosis of sepsis.Methods A prospective single-center single-blind clinical study was conducted. Forty patients with sepsis in intensive care unit (ICU) of Shengjing Hospital of China Medical University from May 2012 to January 2013 were enrolled. The patients were divided into general sepsis, severe sepsis and septic shock groups according to the severity of systemic infection and presence of organ dysfunction. The sepsis patients were again divided into 28-day death group and survival group. Ten healthy volunteers and 11 patients with systemic inflammatory response syndrome (SIRS) were enrolled as healthy control and SIRS groups. The levels of procalcitonin (PCT), IL-33, IL-6, IL-1β, tumor necrosis factor-α (TNF-α), and IL-33 receptor sST2 were determined with enzyme linked immunosorbent assay (ELISA) within 3 hours, and 24 hours and 5 days after enrollment to ICU. The acute physiology and chronic health evaluationⅡ (APACHEⅡ) score was calculated. The clinical outcome, length of stay in ICU, and duration of mechanical ventilation were recorded. The relationship between IL-33 and each parameter was analyzed by Spearman analysis. Receiver operating characteristic (ROC) curve was drawn to evaluate IL-33 in predicting the outcome of sepsis.Results Plasma IL-33 in sepsis patients within 3 hours after admission was significantly increased compared with that of the healthy controls and SIRS group (ng/L: 15.43±7.22 vs. 0.67±0.24, 1.25±1.09, bothP< 0.01). Compared with SIRS group, PCT in sepsis group was significantly increased [μg/L: 52.23 (19.69, 73.37) vs. 1.22 (0.69, 3.73),Z = -2.447,P< 0.001]. With exacerbation of illness, APACHEⅡ score, the values of PCT and IL-33 were gradually increased in general sepsis, severe sepsis and septic shock groups, while the length of stay in ICU and the duration of mechanical ventilation were gradually prolonged (P< 0.05 orP< 0.01). The concentration of IL-33 (ng/L) of sepsis patients admitted to ICU within 3 hours, and 24 hours and 5 days of the illness was 15.43±7.22, 11.82±6.16, 5.55±2.25, respectively (F = 4.823,P = 0.004). There was a positive correction between IL-33 within 3 hours after ICU admission and APACHEⅡ score (r = 0.351,P = 0.031), PCT (r = 0.412,P = 0.005), IL-6 (r = 0.535,P = 0.030), IL-1β (r = 0.674,P = 0.030), TNF-α (r = 0.250,P= 0.030), sST2 (r = 0.620,P< 0.001), and length of stay in ICU (r = 0.296,P = 0.013), duration of mechanical ventilation (r = 0.385,P = 0.011). Decreased plasma IL-33 level could be found in the survivors (n = 37,F = 7.798,P< 0.01), and its level in non-survivors (n = 3) was increased (F = 37.283,P> 0.05). The area under the ROC curve (AUC) of IL-33 and PCT in ROC curve were 0.821, 0.829. When the cut-off value of IL-33 was 13.79 ng/L, the sensitivity was 74.2%, the specificity was 79.6%; when the cut-off value of PCT was 4.70μg/L, the sensitivity was 87.5%, and the specificity was 81.4%.Conclusions The concentration of IL-33 3 hours after ICU admission was obviously increased in sepsis patients, and it was positively correlated with PCT, therefore it is valuable in the diagnosis of the infection. In addition plasma IL-33 is related to the severity of sepsis. Its trend of change is valuable in predicting the outcome and in distinguishing sepsis from SIRS.

Objective: To investigate the effect of Shenfu injection on postoperation of mitral and aortic valve combined replacement surgery.Methods:46 cases, elective patients with mitral and aortic valve combined replacement in September 2008 to December 2009,were randomly assigned into two groups, the observation group 24 patients with the control group 22 patients. The Shenfu Injection, 50ml with 5% glucose injection 250ml,was used on postoperative day and 1-5day after that in the observation group. Other treatments were in the same with the control group patients. Monitoring pre and postoperative left ventricular end systolic diameter (LVSD),left ventricular end diastolic diameter (LVDD),left ventricular ejection fraction (LVEF),biochemicalmarkers of myocardial injury, dopamine dosage and the time of ventilator-assisted breathing. Results: The levels of reducing of left ventricular end systolic diameter and increasing of left ventricular ejection fraction in the observation group were higher than those in the control group(P

Although the evidence-based medicine(EBM) plays an important role in modern medicine,there has been a growing conflict between EBM and the clinical teaching practice in the department of cardiology.By analyzing the reasons,the author has brought forward some suggestions to solve these problems.

This paper has studied the relations between the ancient law including Ur-Nammu's Code,hammurrabi's Code, Hittite Code, Hosaic Law, Talmud, Assyrian Law, Greek Legislation, and X ⅡTables,and the historicaI developrnent of forensic medicine.

The factor and question about equipment purchase approval and management were discussed in this paper.Solutions of how to improve the efficiency and transparence on the equipment purchase and management were put forward.According to this,A Manage System had been designed which made the equipment application,demonstration,verification,bidding,checking and accepting become fluency and dynamic.All the data can be checked from the computer.The working course state is clear at a glance.

Objective To evaluate the clinical curative effect of the non-muscle invasive bladder cancer by selective green laser.Methods 80 cases of non-muscle invasive bladder cancer clinical data were retrospective analysis who received selective green laser treatment.Results All operations were successful,surgery durations were 15-120 min.Patients had basically no intraoperative bleeding,no obturator nerve reflex,without severe complication such as electricity cut syndrome.Postoperative applied of pirarubicin bladder perfusion chemotherapy.All patients were followed-up for 3 months-1 year.No recurred tumor was observed.Conclusion Transurethral selective green laser treatment of non-muscle invasive bladder cancer should be efficient and curative treatment,no serious complications are observed.

Objective To compare the effect of minimally invasive hematoma the quenching aspiration and hematoma evacuation in the treatment of hypertensive basal ganglia brain hemorrhage.Methods 92 patients with hypertensive cerebral basal ganglia hemorrhage underwent surgical treatment were randomly divided into two groups:minimally invasive quenching suction group of 46 patients,craniotomy group of 46 patients.The mortality,complications and activities of daily living(ADL) postoperative three months were observed.Results The mortality rate of the minimally invasive quenching suck group was lower than that of the craniotomy group (8.7％ vs 21.7％,P ＜ 0.05).The postoperative rebleeding and the incidence rate of complications such as lung infections in the minimally invasive quenching suction group were lower than those of the craniotomy group(all P ＜ 0.05).ADL score 3 months postoperatively of the minimally invasive quenching suction group was higher than that of the craniotomy group [(85.53 ± 13.47) points vs (56.12 ± 11.72) points,P ＜ 0.05].Conclusion Minimally invasive hematoma the quenched aspiration in treatment of hypertensive basal ganglia brain bleeding trauma can reduce the mortality,reduce the occurrence of postoperative complications,increase quality of life in patients,has better efficacy for treatment of hypertensive intracerebral hemorrhage.

Objective To investigate the effect of combined use of acupuncture and medicine on T cell subgroups in ulcerative colitis patients. Methods Sixty-four patients with ulcerative colitis were randomly allocated to treatment and control groups, 32 cases each. The treatment group received acupuncture plus medication and the control group, medication alone. After two months of treatment, changes in T cell subgroups were observed in the two groups and the clinical therapeutic effects were compared between the two groups. Results The total efficacy rate was 87.5% in the treatment group and 75.5% in the control group; there was a statistically significant difference between the two groups (P<0.05). There were statistically significant pre-/post-treatment differences in CD3, CD4 and CD4/CD8 in the treatment group (P<0.05). There were statistically significant post-treatment differences in T cell subgroup indices (CD3, CD4 and CD4/CD8) between the treatment and control groups (P<0.05). Conclusions Combined use of acupuncture and medicine is an effective way to treat ulcerative colitis. It can regulate the numbers of CD3 and CD4 and improve bodily immunologic function in the patients.

Taking Shengjing Hospital of China Medical University as an example, informatization management measures are applied to outpatient surgical nursing process, including one-card-through outpatient information diagnosis and treatment model, cell-phone APP clinical message diagnosis and treatment model, electronic queuing system, sub-period and multi-channel reserved registration, medical material receiving, online reporting of the repair work, so as to optimize nursing service process, increase effective treatment time, improve efficiency and quality of nursing service.