1.Thinking about improving the cross-cultural communication capacity of the teaching foreign language on Chinese medicine
Chinese Journal of Medical Education Research 2011;10(9):1047-1049
The purpose of foreign language teaching in Chinese medicine is not only translation,but also clearly the role and the purposes of translation.Inputing a culture to another culture is not culture exchange,but cultural coagulation.Expressions with modem scientific system allow speculative natural philosophy freed from the ancient Chinese-style paper into the theory expressed by modem scientific language in order to solve the problems of teaching foreign languages of traditional Chinese medicine texts.
2.Effect of scopolamine on depression in mice.
Acta Pharmaceutica Sinica 2011;46(4):400-5
Based on the report of previous clinical study which showed cholinergic receptor antagonist scopolamine had antidepressant activity, this study was to investigate the antidepressant activity of scopolamine and explore its effective dose in mice, and to evaluate the effect of scopolamine on the central nervous system and learning/memory ability at its antidepressant effective dose. Tail suspension test, forced swimming test, step-down passive avoidance test and open field test were used to evaluate its effects on mice. Compared with the vehicle control group, single-dose administration of scopolamine (0.1-0.4 mg x kg(-1), ip) significantly decreased the immobility time (P < 0.01 or P < 0.001) in tail suspension test, and significantly decreased the immobility time (P < 0.001) in forced swimming test, but had no effect on the step-down latency and errors in step-down passive avoidance test. Scopolamine (0.1 and 0.2 mg x kg(-1), ip) had no influence on the locomotor activity in open field test, while at dose of 0.4 mg x kg(-1) significantly increase the locomotor activity. These results showed that scopolamine produced reliable antidepressant effect at doses of 0.1 and 0.2 mg x kg(-1), without impairment on learning and memory, as well as excitory or inhibitory effect on central nervous system in mice.
3.Function of fetal microchimerism during disease and tissue repair in parous women
Chinese Journal of Tissue Engineering Research 2012;16(6):1133-1136
BACKGROUND: Fetal microchimerism is a kind of stem cells which comes from fetus in pluripara. The research on fetal microchimerism is a hotspot because it may affect the health condition of pluripara.OBJECTIVE: To introduce the methods of how to detect fetal microchimerism, and the function of fetal microchimerism during disease and tissue repair of the mother.METHODS: Fetal microchimerism was used as a key word, and papers published before 2011-05-20 were retrieved in PubMed. Repetitive papers were eliminated.RESULTS AND CONCLUSION: Totally 655 papers were retrieved, and finally 26 were reviewed. There are several methods used for fetal microchimerism detecting, and fetal microchimerism may pay an important role in the pathomechanism of pluripara autoimmune diseases, cancer and tissue repair.
4.Magnetic resonance imaging of vulnerable carotid plaques:plaque features and risk prediction
International Journal of Cerebrovascular Diseases 2014;22(2):144-149
Carotid artery atherosclerosis is a treatable and preventable cause of ischemic stroke.Increasing studies suggest that carotid plaque characteristics may be a superior means for predicting ipsilateral cerebrovascular events as compared with the degree of carotid artery stenosis.The major MRI features of vulnerable carotid plaques include large lipid-rich necrotic cores,intraplaque hemorrhage,plaque rupture,and calcification.This article reviews the major MRI features of vulnerable carotid plaques and their roles in predicting ipsilateral cerebrovascular events.
6.Investigation on the Low-dose of Computed Radiography
Jinsheng ZHANG ; Shengzhang JI
Journal of Practical Radiology 1992;0(11):-
Objective To research the reduction of computed radiography exposure.Methods By body-model computed radiography test,the relationship between X-ray exposure on the image plate to the latitude and sensitivity of the exposure data recognizer was investigated,from which the low-dose value of exposure was achieved.Results The low-dose value of the computed radiography was 22.5% of the average-dose.Conclusion The low-dose of computed radiography can be achieved.
7.SMAD7 prevents heterotopic ossification by regulating endothelial-mesenchymal transition after Achilles tendon imjury
Chinese Journal of Tissue Engineering Research 2017;21(8):1178-1185
BACKGROUND: The endothelial-mesenchymal transition is known to play a central role in the pathological process of heterotopic ossification. OBJECTIVE: To verify the inhibitory effect of SMAD7 on endothelial-mesenchymal transition such as myofibroblast transformation and to explore whether it is a potential target for heterotopic ossification.METHODS: A lentivirus overexpressing SMAD7 was contructed and the optimal titre and transfection efficiency in rat aortic endothelial cells were determined. The lentivirus was then injected into a rat model of Achilles tendon injury, while the controls were given the injection of normal saline. Expressions of endothelial and mesenchymal markers at the injured site were analyzed by quantitative PCR and western blot assay. The heterotopic ossification was observed radiologically and histologically.RESULTS AND CONCLUSION: Local injection of SMAD7-delivering lentivirus resulted in an upregulation of CD31 and VE-cadherin, and a downregulation of N-cadherin and vimentin, suggesting that the endothelial-mesenchymal transition is blocked due to local SMAD7 overexpression. The inhibitory effect became more evident at 10 weeks than at 6 weeks after modeling. Radiology and histological staining further confirmed that the ossified structures in the tendon tissue disappeared after injection of SMAD7-delivering lentivirus, as opposed to the control group. These data suggest that local overexpression of SMAD7 can prevent postoperative heterotopic ossification with no effect on wound healing.
8.CT and MRI diagnosis of facial nerve neuroma
Chinese Journal of Radiology 2001;0(07):-
Objective To investigate the CT and MRI findings of facial neuroma to promote diagnostic accuracy. Methods Nine facial neuromas consisted of 8 schwannoma and 1 neurofibroma. High resolution CT were performed on 7 cases, routinal CT scan on 2 patients. Six cases were examined by MRI, in which 5 cases were used constrast media. Results Five tumors on right side and 4 on left were detected. The tumor affected the internal auditory canal segment of facial nerve in 1 case, labyrinth segment in 4, anterior genu in 6, tympanum segment in 7, mastoid segment in 6,horizontal segment in 5 and parotid segment in 3. CT demonstrated enlargement of the facial nerve canal, benign bone remodeling in the location of geniculate ganglion and stripe soft issue along the course of facial nerve. MRI found that involved facial nerve became thickened markedly as a stripe or soft mass by several segments, that were isointense to brain on T 1WI and isointense or hyperintense on T 2WI and enhanced obviously. Conclusion The segmental soft tissue mass along the facial nerve course is the characteristic of facial neuroma. Gadolinium enhanced MRI is an effective method for detecting the lesion.
9.Study of Risk Factors of Nosocomial Infection in Intracerebral Hemorrhage
Chinese Journal of Nosocomiology 2001;11(1):4-6
OBJECTIVE In order to explore and control the risk factors of nosocomial infection in intracerebral hemorrhage.METHODS To study prospectively in 837 hospitalized patients with intracerebral hemorrhage in our hospital from Jan.1997 to June 1999. RESULTS It was showed 215 cases of the nosocomial infection were found among 837 cases with the intracerebral hemorrhage(25.8%).Among them,nosocomial lower respiratory tract infection was the highest(39.1%),the second one was the urinary tract(27.8%).Nosocomial infection was closely related with such factors as the aging,location and volume of intracerebral hematoma,disturbance of consciousness, smoking,blood sugar,invasive operation,antibiotic prophylaxis,bed-days.Whereas serum cholesterol was a protective factor.CONCLUSIONS Nosocomial infection was still a high frequent complication in intracerebral hemorrhage and it should be paid attention.This is the most important step to control nosocomial infection of intracerebral hemorrhage in the hospital.
10.Improvement of mouse spermatogonial cells transplantation method
Acta Anatomica Sinica 2010;41(1):165-168
Objective To improve the current method of spermatogonial cells transplantation, and make the new method become more operative and easy to carry out. Methods The spermatogonial cells in rC57BL6/tg14 (act-EGFO-Osb Y01) mice that expresse GFP protein were collected as the donor cells, and by using a modified syringe, and then were injected into the seminiferous tubules of pretreated wild type GFP-null mice through testicular efferent duct. The transplantation outcome was evaluated by trypan blue stainting and fluorescent microscopic examination and pathohistological analysis of transplanted testis. Results The transplanted testis of recipient mice showed green fluorescence signal, and the signal of seminiferous tubules was found significantly higher than that of the surrounding tissues. The transplanted GFP-positive cells generated colonies and spermatogenesis but pretreated wild type GFP-null mice were not found. Conclusion The expressed GFP protein spermatogonial cells in rC57BL6/tg14 mice were successfully transplanted in the wild type GFP-null recipient mice, fourthermore the improved transplantation method simplified the triditional one and achieved the same transplantation results.