Objective To explore the clinical value of testing LDH and IL-2 in the serum of the patients with the acute leukemia. Methods The LDH and IL-2 in the serum of 15 patients with the acute leukemia were tested,who consist of the patients with first treatment,recurrence and remission,compared with these of the normal people in control group.Results The LDH of the patients with first treatment and recurrence was obvious higher than tllat of the patients with remission;the IL-2 of the patients with first treatment and recurrence was obvious lower than that of the patients with remission.The LDH descent and IL-2 ascent were found in the patients with remission.Conclusion The cell load of the patients with the acute leukemia can depress the expression of IL-2 in the patients with the acute leukemia.

The initiation and development of gastric cancer is due to the effects from both external and internal factors.Recent researches show that external environment factors regulate and control the key genes expression during the process of cell's growth and development through epigenetic modification such as DNA methylation or demethylation,histone modification and small RNA,thus playing an important role in gastric cancer's occurrence and development.

Objective:To evaluate the application status and change trends of insulin and its analogs in Nanjing area during 2011 to 2013. Methods:The varieties, sales amount and DDDs of insulin and its analogs in 43 hospitals of Nanjing during 2011 to 2013 were analyzed. Results:The use of insulin and its analogs was increased year by year from 2011 to 2013 with the average annual growth rate of 16%. Glargine, pre-mixed insulin 30R, aspart 30, human insulin and aspart ranked the top five in the sum of money with the proportion above 80%. Pre-mixed insulin 30R, aspart 30, glargine, human insulin and common insulin ranked the top 5 in DDDs. Conclusion:The application of insulin and its analogs is wide in clinics, and the usage and sum of money both show rapid growth trend.

Because of their physiological and anatomical immaturity, premature infants are prone to disorders of glucose metabolism. In the ifrst week after birth, infants have the greater risk of abnormal glucose metabolism. Compared with term infants, the glucose/insulin homeostasis of preterm infants is very different. This article reviewed the characteristics of glycometabolism in premature infant and the methods of glucose test.

Objective: To examine the effect of group mental intervention on implicit and explicit aggression of violent juvenile criminals. Methods: A survey investigation and IAT test on implicit aggression were employed to evaluate the aggression of violent juvenile criminals. And the effect of ten times of group intervention on aggression of juvenile criminals was analyzed. Results: After group mental intervention, the implicit aggression was not reduced significantly, but the intervention effect on explicit aggression was significant. Physical aggression and verbal aggression of explicit aggression reduced significantly, but there was no significant difference in rage and hostility. Conclusion: Group mental intervention is an effective method for reducing explicit aggression of violent juvenile criminals.

Objective To investigate the relationship between concurrent mental disorders and original respiratory diseases.Methods 35 cases diagnosed as severe respiratory diseases accompanied by various mental disorders from July 2005 to December 2008 were analyzed with the clinical presentation,examination,diagnosis and treatment.Results After the treatments of the original respiratory diseases and the necessary psychiatric drugs,the original respiratory diseases relieved and the symptoms of mental disorders disappeared.Conclusion Much more attention should be paid to concurrent mental disorders of respiratory diseases,and the timely treatments of symptoms of mental disorders will be of benefit to the therapy of original diseases.

The present study was undertaken to identify some afferent connections of the ventral and dorsal parts of pontine tegmentum in guinea pigs by using horseradish peroxidase retrograde microelectrophoretic technique.After introducing HRP into the ventral part of pontine tegmentum, numerous labeled cells were observed in the mesencephalic central gray and related reticular formation, which is equivalent to the MSR (Mesencephalic Stepping Region) ventral to the surface of the superior colliculus. Labeled cells could also be identified at the following sites: nucleus cuneiformis ventral to the surface of inferior colliculus, nucleus tractus spinalis nervi trigemini, nucleus reticularis gigantocellularis, nucleus medialis vestibulares, nucleus lateralis vestibulares, nucleus loci coerulei and its ventral part, gray matter of the cervical enlargement of spinal cord.Following injection of HRP into the dorsal part of pontine tegmentum, substantial amount of labeled cells were observed in the nucleus reticularis pontis caudalis and nucleus reticularis gigantocellularis Labeled cells gould also be identi- fied in the nucleus medialis vestibulares, nucleus lateralis vestibulares and nucleus cuneatus. Only a few HRP cells appeared around the nucleus tuber in the midbrain and no labeled cells have been seen in the nucleus loci coerulei, as well as the gray matter of cervical spinal cord.

0.05). ③All of the OSAHS patients suffered seri-ous lipid metabolic disorders. CONCLUSION ① Fatty infiltration in the pharyngeal tissue may lead to collapse of the pharyngeal airway during sleep. ②The epithelial cells of mucosa,endothelial cells of small vessels and glandular cells of minor salivary glands can potentially produce leptin. Leptin existing with Ob-Rb shows the peripheral action of leptin. The positive ex-pression of leptin and Ob-Rb had no significant differ-ence between the two groups, which may explain theectopic accumulation of lipid. ③ Disordered lipid me-tabolism may not be the determinant factor in the patho-genesis of OSAHS. ④ Endogenous hyperleptinemia may be the protective response to respiratory distur-bance and disordered lipid metabolism, and is also as-sociated with the continuous hypersympathetic activity. The level of leptin in plasma has a positive correlation with the severity of OSAHS.

0.05). In the field of side effects,especially EPS,weight gain,lactation and menstrual disorders,aripiprazole was significantly lower than risperidone(P

Objective To explore the clinical value of enhanced recovery after surgery (ERAS) in the perioperative period of biliary surgery.Methods The prospective study was adopted.The clinical data of 800 patients diagnosed as benign biliary tract diseases who were admitted to the Cangzhou's Central Hospital from March 2011 to January 2015 were collected.Patients were randomly divided into the case and control groups by random sequence method.The patients of case group received the ERAS management and patients of the control group received traditional perioperative management.(1) Stress state evaluation:the insulin resistance (IR) index and level of serum C-reactive protein (CRP) were calculated.(2) Levels of inflammatory cytokines:levels of IL-6 and TNF-α in the 2 groups were detected by enzyme-linked immunosorbent assay (ELISA).(3)Nutritional status:level of serum prealbumin (PA) was detected.(4) Postoperative status:time to anal exsufflation,time of defecation,duration of hospital stay and treatment expenses were recorded.(5) Postoperative complications were observed.Measurement data with normal distribution were represented as x ± s and comparison between groups was analyzed using t test.Repeated measurement data were analyzed by the repeated measures ANOVA.Count data were represented as ratio and analyzed using the chi-square test.Results The 800 patients were screened for eligibility,including 400 in each group.(1) Stress state evaluation:the levels of IR and CRP from pre-operation to 7 days after operation were from 3.8 ± 0.8 to 3.7 ± 0.7 and from (18 ± 5) μg/L to (27 ±8) μg/L in the case group,from 3.9 ±0.9 to 3.8 ±1.0 and from (18 ±5) μg/L to (38 ±9) μg/L in the control group,respectively,with statistically significant differences in the changing trends (F =12.38,17.85,P ＜0.05).(2) Comparisons of levels of inflammatory cytokines:levels of IL-6 and TNF-α from pre-operation to 7 days after operation were from (9.3 ± 3.1) ng/L to (12.5 ± 2.8) ng/L and from (10.2 ± 3.5) ng/L to (12.8 ±3.3)ng/L in the case group,from (8.9 ±3.3)ng/L to (17.3 ±6.5)ng/L and from (9.9 ±2.8) ng/L to (14.3 ±4.2)ng/L in the control group,with statistically significant differences in the changing trends (F =19.93,15.74,P ＜ 0.05).(3) Comparison of nutritional status:level of PA from pre-operation to 7 days after operation was from (335 ± 53)mg/L to (332 ±50)mg/L in the case group and from (330 ± 49)mg/L to (331 ± 45)mg/L in the control group,with a statistically significant difference in the changing trends (F =4.46,P ＜ 0.05).(4)Comparisons of postoperative status:time to anal exsufflation,time of defecation,duration of hospital stay and treatment expenses were (30 ± 10)hours,(51 ± 13) hours,(7.7 ± 2.5) days,(10.2 ±2.3) × 103 yuan in the case group and (54 ± 8) hours,(70 ± 16) hours,(15.4 ± 3.1) days,(15.6 ± 4.7) × 103 yuan in the control group,with statistically significant differences (t =37.73,18.62,38.67,20.64,P ＜0.05).(5) Comparisons of postoperative complications:incidence of complications was 15.00％ (60/400)in the case group and 22.50％(90/400) in the control group,and the numbers of patients with incision infection,nausea and vomiting,abdominal infection,intra-abdominal infection,urinary tract infection,intro-abdominal hemorrhage and bile leakage were 23,15,8,5,4,3,2 in the case group and 30,20,13,10,7,5,5 in the control group,respectively,showing statistically significant differences in the incidence of complications (x2=7.39,P ＜ 0.05).Conclusion ERAS management in the perioperative period of biliary surgery is beneficial to postoperative recovery of patients,and it can also relieve postoperative stress state and inflammatory response,reduce the duration of hospital stay,treatment expenses and incidence of postoperative complications.