Infection is one of the most frequent complications in liver failure and results in high mortality rates.Patients with liver failure have altered and impaired immunity,which favors bacterial translocation.The most common infections in liver failure are pneumonia,spontaneous bacterial peritonitis (SBP),urinary tract infections (UTI),and bloodstream infection.Risk factors associated with the development of infections are variceal bleeding,low ascitic protein level,using of hormones,using of antibiotics,and application of invasive operation,etc.The prognosis of these patients is closely related to a prompt and accurate diagnosis.An appropriate treatment decreases the mortality rates.Preventive strategies are the mainstay of the management of these patients.