1.Accuracy of transcutaneous bilirubin determination in neonatal hyperbilirubinemia: A meta-analysis.
Jean Kamil L. Sy ; Michael M. Resurreccion
The Philippine Children’s Medical Center Journal 2019;15(1):66-76
BACKGROUND:
Timely initiation of therapy for neonatal hyperbilirubinemia is routinely made based
on total serum bilirubin levels. However, serial samplings by invasive needle pricks are needed for
laboratory analyses. Studies comparing the correlation between serum bilirubin and transcutaneous
bilirubin have yielded diverse results. A meta- analysis was done to find out the relationship between
transcutaneous bilirubin measurements and serum bilirubin values.
OBJECTIVE:
This study aims to analyze scientific articles regarding the accuracy of transcutaneous
bilirubin measurements among healthy neonates as an alternative screening for hyperbilirubinemia.
STUDY DESIGN:
Diagnostic Accuracy meta- analysis.
METHODS:
Studies on the accuracy of transcutaneous bilirubin measurements were identified through
intensive literature search. Local studies were confirmed thru personal communication.
RESULTS:
Three hundred eighteen studies were identified through literature search. Ten studies met the
eligibility criteria. Eight of the ten studies reported results as correlation coefficients. The pooled
estimates of correlation coefficients is high at r = 0.85 (95% CI = 0.84 to 0.857). Five studies reported
results with data for diagnostic accuracy. The pooled analysis for sensitivity and specificity are high at
0.84 (95% CI 0.8-0.88) and 0.79 (95% CI 0.77-0.81) respectively. The pooled likelihood ratio has a
significant difference with a pooled positive LR of 4.19 (95% CI 2.98-5.9, P<0.01) while the negative
likelihood ratio is 0.23 (95% CI: 0.17 to 0.29). The AUC for transcutaneous bilirubinometry is 0.89.
CONCLUSIONS
Transcutaneous bilirubin measurement can be an alternative in monitoring the risk of
healthy neonates for hyperbilirubinemia based on the pooled analysis of correlation coefficient and
diagnostic accuracy.
2.RUNX1::RUNX1T1 Fusion in Pediatric Acute Myeloid Leukemia: A description of two cases.
Jill Jaime ; Ivy Mae Medalla ; Steffanie Charlyne Tamayo ; Qareem Pido ; Francisco Tria IV ; Ma. Luisa Enriquez ; Jean Kamil Sy ; Reynaldo De Castro Jr. ; Daphne Ang
Philippine Journal of Pathology 2023;8(1):42-48
RUNX1::RUNX1T1 is a core-binding factor driving fusion gene which arises from t(8;21)(q22;q22). It is one of the
most common chromosomal rearrangements in both pediatric and adult Acute Myeloid Leukemia (AML)
with a reported incidence o 15% in children and young adults. There are few case reports documenting
RUNX1::RUNX1T1 translocation in pediatric AML. Although this is generally associated with a favorable
prognosis, we report two (2) cases of de novo pediatric AML in the Philippines harboring a RUNX1::RUNX1T1
translocation, one eventually relapsed while the other attained remission but succumbed to sepsis.
Next Generation Sequencing
;
RUNX1::RUNX1T1 fusion