1.Antidiabetic potential and high synergistic antibacterial activity of silver nanoparticles synthesised with Musa Paradisiaca tepal extract
Chinnakrishnan Shanmuga Sundaram ; Jayaprakash Sivakumar ; Suresh Kumar Subbiah ; Thant Zin ; Mahadeva Rao Uttarkar Sathyanarayana Rao
The Medical Journal of Malaysia 2021;76(1):80-86
This work investigates the Musa Paradisiaca plant and its
tepal extracts. The research findings show that the tepal
extracts of M. Paradisiaca contain high phytochemical
activity. Hence we can conclude that these plants have a
number of beneficial properties. Phytochemical analysis
concludes that the plant is rich in flavonoids, phenolic
compounds, tannins, terpenoids, and phytosterol. In the
current work, silver nanoparticles (AgNPs) have revealed the
antioxidant properties of M. Paradisiaca. The results show
that the methanolic extracts of these tepals exhibit
antioxidant potential and are also sources of natural
antioxidant compounds, though comparatively, AgNPs have
shown the best antioxidant activity. This work investigates
the link between the ethnopharmacological statements and
the bioactive constituents found in M. Paradisiaca toward all
probable markers for cervical cancer via in vivo studies and
molecular docking, to form a pharmacophore setting for the
active target. However, most of the mechanisms of action of
herbal medicines are not in total agreement, and the
information collected from their traditional remedies over
the years must not be neglected. Hence, it is sensible to
investigate the options available in herbal medicine for
cancer progression. Biosynthesised AgNPs are principally
spherical and nanosized. It was also found that tepalmediated AgNPs exhibit excellent antimicrobial efficacy
against tested human pathogens. This green method can be
used as a better alternative source than the chemical
fabrication of nanomaterials and the biosynthesised
nanoparticles can be used in antibacterial medicines. The
methanolictepal extract of M. Paradisiaca with AgNPs
displayed proficient antidiabetic properties in the diabetes
rat model and so could have a possible development for
medical use in the future