Objective To investigate the mechanism of renal protective effect of rosiglitazone on diabetic rat kidney. Methods Eighteen rats were assigned to normal control(C) group,diabetic rat(DM) group, rosiglitazone(5 mg?kg-1?d-1)treatment(R) group.Immunohistochemistry,RT PCR,Western blot were used to examine the pathological change of kidney and expression of PPAR?、TGF ?1 after 8 weeks in the kidney of rats. Results In comparison with normal group, the expression of PPAR?and TGF ?1 in diabetic rat and treatment groups was markedly increased(P
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