Background: Gishuun-3 medicine is widely used for mild laxative, reverse elimination of flatulence, constipation, and amennorrhea. Therefore, the basis of our research work is to select the medicine Gishuun-3, keep the medicinal composition intact and make it in the form of granules for easier to consume. Aim: To study the possibility of using the drug Gishuun-3, which has been widely used in traditional medicine, in the form of granules. Materials and Methods: “Gishuun-3” The composition of the drug contains Gishuun, Arur, and Khujir. The following methods and techniques were used to conduct the study. These include: The following methods and methodology were applied in the study: Quality parameters of the granules were determined by Mongolian National First Pharmacopoeia. TLC was used to detect some biologically active substances that are predominant|y present in the granules.Quantitative analysis of some biologically active substances that are predominantly present in the granules were determined by spectrophotometry. Results: Gishuun-3 was weighed in an appropriate amount, and 6 types of granules were produced by the method of wet granulation using glucose, lactose, sucrose, lemon juice, sodium carboxymethyl cellulose (NaCMC), and vanilla (sugar) as auxiliary fillers. The M6 type granules were selected for further research and the technological instructions were developed. Gallic acid and polyphenols contained in Gishuun-3 granules were identified by thin-layer chromatography. The amount of polyphenolic compounds mainly contained in the granules was determined by spectrophotometry using Folin-Chikalto reagent. It was determined that the granules meet the requirements for determining the quality criteria required for the formulation of the drug, and it was determined that Gishuun-3 granules can be formulated into the form of granules. 0.202+0.002%. Conclusions 1. Among the 6 types of granular drugs selected in the study, the M6 model granules containing Member-3 tang thick extract, glucose, lactose, sucrose, lemon juice, sodium carboxymethyl cellulose (NaCMC), and vanilla (sugar) honey were determined to be the most suitable for further research because they met the technological parameters and quality criteria of the granular drug, and a technological scheme for producing this granular drug was developed. 2. In determining some quality criteria of the extracted granular drug, the moisture content was 1.48±0.16%, the size of small particles was 4.43±0.13%, and the dispersion or distribution was 2.0±0.11% minutes, which met the general requirements for granular drugs. 3. The total polyphenolic compounds contained in Gishuun-3 granules were determined by spectrophotometry to be converted to gallic acid and were 0.202±0.002%.

Background: Liposomes have been widely studied in the field of medicine in recent years for they can reduce side effects and regulate drug release by delivering active ingredients to target tissues and cells through active or passive routes. There are many types of methods for formulating liposomes, and comparing those methods and choosing the most suitable one will allow the delivery of active ingredients and their incorporation into pharmaceutical forms, so this research was carried out. Aim: To compare liposome formation methods. Materials and Methods: The research work was carried out with the support of “Drug Design Laboratory” and “Pharmaceutical Analysis Laboratory” of the School of Pharmacy of MNUMS. To formulate liposomes, 5 different concentrations of samples were prepared using thin-film hydration, ethanol injection, and heating methods. Phospholipid concentration and light absorption were determined by spectrophotometer in each sample. The size of the resulting liposome was determined using a Nanophox. Results: Phosphatidilcholines were dissolved in distilled water at concentrations of 5, 10, 20, 30, 40, and 50 μg/ml and a standard curve was established by spectrophotometry to determine the concentration of phospholipids in liposome samples. The highest formulation was 76.98% when 75 mg of phospholipid was used in the preparation by thin film hydration method, when 50 mg of phospholipid was used in the preparation by ethanol injection method, the highest formulation was 85.17%, and for when 50 mg of phospholipid was used in the preparation by heating method, the highest formulation was 58.45%. The mean liposome size by ethanol injection method was 115 nm. Conclusions 1. Ethanol injection method for liposome formulation is more efficient compared to thin-film hydration method and heating method. 2. Liposome size was 115 nm when prepared by ethanol injection.

Background: In Mongolia, 80.1% of women of reproductive age suffer from vitamin D deficiency. This deficiency is associated with an increased risk of rickets, osteomalacia, weakened immunity, hypertension, diabetes, and infectious diseases.Currently, Mongolia imports vitamin D-containing pharmaceutical products, and no research has been conducted on the pharmaceutical formulation technology of orally administered vitamin D3 products. Vitamin D3 is highly sensitive to environmental factors such as ultraviolet (UV) light, oxidation, and temperature changes, leading to its degradation. Therefore, improving its stability in pharmaceutical formulations is essential. The need for a stable vitamin D3-containing pharmaceutical product serves as the basis for this study. Aim: To develop a tablet formulation containing cholecalciferol. Materials and Methods: The study was conducted in collaboration with the Department of Pharmaceutical Technology at the School of Pharmacy, Mongolian National University of Medical Sciences, and the drug development laboratory of “Monos Pharm” LLC. To enhance the stability and technological properties of cholecalciferol, a spray-drying technique was used to prepare five different emulsions containing various excipients. Microencapsulation was performed to improve stability, and the most suitable formulation and technological parameters were selected. From the microencapsulated cholecalciferol, tablet formulations were developed using both direct compression and wet granulation techniques. The quality parameters of the tablets were assessed according to the United States Pharmacopeia (USP), and the optimal technological process for tablet production was determined. Results: A stable microencapsulated cholecalciferol formulation was successfully developed, and suitable excipients were selected. The quantitative content of cholecalciferol was determined to be 1791 IU, with variations ranging from -8.38% to -11.38%. Conclusion The study identified appropriate excipients and technological parameters for obtaining microencapsulated cholecalciferol. Additionally, the optimal formulation and processing parameters for developing a tablet dosage form containing microencapsulated cholecalciferol were established.

Background: Vitamin E is an oil-soluble compound with antioxidant properties against free radicals. It has been used in cosmetic practice since long time ago. However, it is unstable to light and heat, and even when formulated into pharmaceuticals, it has poor skin penetration, which can reduce the effectiveness of the treatment. Therefore, by encapsulating Vitamin E in liposomes and forming a gel, it is possible to produce a highly therapeutically effective drug form that supports skin homeostasis and provides moisturizing benefits. To this reason, it is necessary to determine the appropriate methods and conditions for encapsulation in liposomes, which is the basis for conducting this study. Aim: The goal of the research is to develop a technology for preparing vitamin E-loaded liposomes and incorporating them into a gel formulation. Materials and Methods: Liposomes were formed using thin film hydration, ethanol injection, and heating methods, each with 5 different concentrations, and liposome formation was determined spectrophotometrically for each sample. The size of the formed liposomes was determined using a Nanophox instrument. Six gel models were prepared and compared for quality parameters. Results: The highest yield was obtained when 75 mg of phospholipids were used in the thin film hydration method, which is 82.3%; the highest yield was obtained when 50 mg of phospholipids were used in the ethanol injection method, which is 86.75%; and the highest yield was obtained when 50 mg of phospholipids were used in the heating method, which is 58.8%. The average size of liposomes prepared by ethanol injection and dissolved in distilled water was 106 nm. The gel bases were prepared using models F1-F6, and the pH values of models F4 and F5 were suitable. Conclusions 1. Among the three methods for liposome formation, the ethanol injection method had the highest yield. 2. The ethanol injection method had the highest encapsulation when prepared with a phospholipid:vitamin E ratio of (1:10). 3. For gel base model F5 was suitable which is carbomer 1.0%, preservative propylparaben 0.02%, pH adjuster sodium hydroxide, and permeability enhancer propylene glycol 10%.