OBJECTIVE: Treatment of prostatitis continues to be a challenge. The authors evaluated the culture andsensitivity of expressed prostate secretion of patients with bacterial prostatitis in the local setting. MATERIALS AND METHODS: All patients who were suspected to have prostatitis underwent expressedprostate secretion cultures. All positive cultures were then included in the study. RESULTS: One hundred six (106) culture positive examinations were included in the study.Staphylococcus species were the most common organisms at 55% (59/106), followed by Enterococcusspecies at 17% (19/106). Over-all, Vancomycin was still the antibiotic the organisms were mostsensitive to among all the antimicrobials regardless of organism cultured at 69% (74/106) followedby Ciprofloxacin at 43% (46/106). CONCLUSION The study showed some discrepancy with current known epidemiological studies on theincidence of the organisms causing bacterial prostatitis. It also showed that the current most commonlyused antimicrobial agent (fluroquinolone) may have a high resistance rate that is not acceptable as anempiric treatment hence the investigators recommend at least the use of expressed prostate secretionculture study as guide for the management of prostatitis.

While prostatic calculi are said to be overwhelmingly common, it is, however, rare to find patientswith exceptionally large calculi that would cause urinary tract obstruction. Indeed, prostatic calculigenerally remain asymptomatic in almost all men, because of its non-obstructive nature. Presentedhere is the case of a 48-year-old male with one giant prostatic calculus that replaced almost the entiregland. He underwent endoscopic and open surgical management for the stones.

A patient with known prostatic cancer presented with left supraorbital swelling with proptosis and restricted eye movements on left eye. Contrast enhanced computed tomography scan revealed dural and bone metastases with soft tissue component extending to the left orbit. Serum prostate specific antigen was markedly elevated at >100 ng/ml. Incision biopsy of the orbital tumor revealed only lymphocytic inflammatory cells within the fibrous stroma attributed mainly to the deeper location of the tumor or shallow locus of the biopsy. Incisional biopsy of the frontal bone revealed atypical looking cells in sheet cluster with nuclear enlargement, hyperchromatic in irregularity confirming the diagnosis of orbital metastasis of prostate carcinoma.

Metastasis of prostate cancer to the orbit is rare. One should have a high index of suspicion of orbital metastasis when presented with an elderly patient with ocular symptoms and a history of prostate adenocarcinoma. A thorough clinical, radiological and histological evaluation is necessary to establish the diagnosis.

Human ; Male ; Aged ; Neoplasm Metastasis ; Adenocarcinoma ; Prostatic Neoplasms ; prostate-biopsy ; eye ; Tomography Scanners, X-Ray Computed

OBJECTIVE: To examine the ability of an antimicrobial agent Ciprofloxacin to diffuse through a Foley catheter retention balloon.
METHODS: The Utraviolet-Visible (UV-Vis) Spectophotometer (UV-1700 PharmaSpec) was utilized to detect the diffusion of the analyte (Ciprofloxacin) through end parameters such as peak absorbance and corresponding wavelengths.
RESULTS: On UV-Vis spectophotometer, the control sample of sterile water was analyzed and found to have the lowest peak absorbance value of only 0.003 at a wavelength of 343 nm. The peak absorbance values of subsequent samples, taken from the same environment (sterile water), since submersion of the catheter balloon, on day-3, day-8, day-15 had increasing peak absorbance values on their corresponding wavelengths.
CONCLUSIONS: In this study, the samples of sterile water from the outside environment of the submerged catheter yielded progressively increasing peak absorbance values on the succeeding days of submersion. Thereby, In lieu of this principle, one can infr the diffusion of the analyte throgh the catheter membrane, as reflected by the summary of peak absorbance value.

Ciprofloxacin ; Water ; Immersion ; Anti-infective Agents ; Diffusion ; Membranes ; Urinary Catheters