Objective: To examine the mediating effect of nighttime sleep duration on pain and frailty among elderly patients with comorbidity of chronic diseases, so as to provide insights into frailty control among the elderly. Methods: Demographic information, pain and nighttime sleep duration of the elderly at ages of 60 years and older were collected from the China Health and Retirement Longitudinal Study 2020. Frailty were evaluated using frailty index. The mediating effect of sleep duration for pain and frailty was analyzed using the Process program compiled by HAYSS and colleagues, and the significance of the mediating role was tested using the Bootstrap test. Results: A total of 2 246 elderly patients with comorbidity of chronic diseases were enrolled, including 1 195 males (53.21%) and 1 051 females (46.79%), with a median age of 65.00 (interquartile range, 8.00) years. There were 504 cases with frailty (22.44%), with a median pain score of 0 (interquartile range, 1.00) points, and a mean nighttime sleep duration of (6.44±1.55) hours. Mediating analysis showed that pain affected frailty directly and positively with the effect value of 0.089 (95%CI: 0.066-0.112), and also affected frailty by nighttime sleep duration directly and positively with the effect value of 0.047 (95%CI: 0.036-0.058), with the mediating effect contributed 34.56% of the total effect. Conclusion Pain can directly or indirectly affect frailty among elderly patients with comorbidity of chronic diseases through nighttime sleep duration.

Objective: To explore the effects of auricular point stimulation on constipation among college students and to provide a reference for improving constipation among college students. Methods: Between September 15 and September 30, 2019, the International Nursing College of Hainan Medical College Nursing School Survey, which included the constipation assessment scale (CAS), was conducted among 603 female college students. There were 90 cases of functional constipation, which were divided into a control group and an observation group of 45 cases each using the random number table method. The control group was given health education and behavioral guidance, such as a diet intervention, an exercise intervention, an emotional management intervention, and guidance on defecation habits, etc, via WeChat. The observation group received auricular stimulation intervention in addition to the control group measures. Before and two weeks after the intervention, the Wexner constipation and the Patient Assessment of Constipation Quality of Life (PAC-QOL) scales were used to assess the effect of auricular stimulation on students with constipation. Results: Before intervention, there was no significant difference in the Wexner constipation scores between the two groups (P>0.05). After the intervention, the Wexner constipation scores in the observation group were lower than those in the control group, and the differences were statistically significant (t=8.38, 8.95, 11.96, 9.08, 6.45, 13.18, 11.93, 6.19, P<0.05). Before intervention, there was no statistically significant difference in PAC-QOL score between the two groups (P>0.05). After intervention, the difference in the control group s PAC-QOL scores on all dimensions and total dimension score lower earlier, was statistically significant (t=5.29, 6.64, 10.28, 7.81, 9.60, P<0.01). The observation group s PAC-QOL scores after the intervention were lower compared to before the intervention (t=7.98, 11.81, 11.44, 6.93, 8.81, P<0.01), and the difference was statistically significant. All individual and total dimension scores of the observation group and the control group were significantly lower than those of the control group, and the difference was statistically significant(P<0.05). Conclusion Auricular stimulation of TCM can significantly improve the constipation score of college students and improve their quality of life.

Objective:To investigate the effects of intraoperative irrigation with hypothermic 3% sodium chloride solution on surgery effect and post-tonsillectomy pain in adults.Methods:A total of 120 adult patients with the plasma tonsillectomy from January to December 2020 in the First Affiliated Hospital of Soochow University were divided into observation group A, observation group B, observation group C and control group according to random number table method, with 30 cases in each group. During operation, observation group A used hypothermia 3% sodium chloride, observation group B used room temperature 3% sodium chloride, observation group C used hypothermia 0.9% sodium chloride, control group used room temperature 0.9% sodium chloride. The quality of surgical field quality, operation time, blood loss in operation, duration of catheter, the postoperative wound pain at 24, 48, 72 h after operation were compared among four groups.Results:The surgical field quality scores were (2.07 ± 0.87) points in the observation group A, significantly lower than in the observation group B (2.57 ± 0.73) points, observation group C (2.60 ± 0.56) points and control group (3.10 ± 0.66) points, the differences were statistically significant ( t=2.71, 2.89, 5.61, all P<0.01). Amounts of blood loss in operation were (9.13 ± 1.74), (10.03 ± 2.81), (10.50 ± 2.09) ml in the observation group A, observation group B and observation group C, significantly lower than in the control group (15.23 ± 3.64) ml, the differences were statistically significant ( t=8.85, 7.54, 6.87, all P<0.01). At 24 h after operation, the scores of Numerical Rating Scale(NRS) were (3.23 ± 0.77), (3.53 ± 0.63), (3.80 ± 0.89) points in the observation group A, observation group B and observation group C, significantly lower than in the control group (4.43 ± 1.17) points. At 48 h after operation, the scores of NRS were (2.37 ± 0.72) points in the observation group A, significantly lower than in the control group (2.93 ± 0.83) points, the differences were statistically significant ( t values were 2.77-5.25, all P<0.01).There was no significant difference in operation time, duration of catheter and wound pain 72 hours after operation among the four groups ( P>0.05). Conclusions:Intraoperative use of hypothermic 3% sodium chloride solution can reduce the amount of blood loss in operation in adult patients with plasma tonsillectomy, increase the clarity of visual field, and effectively reduce postoperative pain.