Objective: To discuss the curative effect of trace hormone combined with antibacterial drugs on bacterial keratitis. Methods:Totally 80 cases of patients with bacterial keratitis were selected and divided into the observation group and the control group at random. The patients in the two groups were given medical treatment with sensitive antibiotics, while the patients in the observation group were additionally given trace cortisol. The clinical curative effect and vision recovery time in the two groups after the 3-week treatment were observed, and the occurrence of complications in the 2-month following-up after the medical treatment was compared as well. Results:After the 3-week medical treatment, the clinical effective rate and vision recovery effective rate in the observation group were much higher than those in the control group (P<0. 05). In the 2-month following-up after the medical treatment, the occurrence of complications in the observation group was much lower than that in the control group (P<0. 05). Conclusion:Trace hormone com-bined with antibacterial drugs has favorable curative effect on bacterial keratitis, which can effectively enhance the healing of helcoma, improve the vision recovery and reduce the occurrence of complications.

Together with Chinese mainstream ideology of equality between men and women,feminism has been profoundly impacted on women's bioethical attitudes and behaviors in contemporary Chinese society.The tension between women's pursuing for physical beauty and survival lasting shows that,under the influence of feminism,women have been out of attachment to men and gained equality with men and the independence,autonomy of life,but there will still be potential crisis of Bioethics.Therefore,referring to female bioethical issues,close attention must be paid to making use of the positive impact to feminist consciousness of feminism,and meanwhile prevent the distortion of feminist consciousness and crisis on Bioethics.

Objective To analyze the effect of the application of PDCA circulation in the management of oral instruments.Methods From January to June 2015,the head nurses analyzed problems of instruments management according to the outpatient instrument management and requirement standards in the department of stomatology.They followed the PDCA circulation principle,put a continuous improvement,and compared the changes in the management of oral instruments before and after 4 months (from March to June and from July to October) Results After the implementation of the PDCA circulation,the abnormal loss of equipment,numbers of instrument loss and equipment failure rate had significantly decreased,while equipment utilization rate had significantly increased,with significant statistical differences (P ＜ 0.05) Conclusion The application of PDCA circulation in the management of oral instruments could help reduce the problems of abnormal waste,loss,failure and so on,resulting in improving the instrument utilization rate.

Objective:To evaluate clinical significances of the immuno pathogenic type of recurrent spontaneous abortion (RSA) Methods:Immunological analysis was made in ABO group antibodies by indirect hemagglutination, anti zona pellucida antibodies by BA ELISA, anti phospholipid antibodies by ELISA, blocking effect (MLR BE) by blocking test of one way mixed lymphocyte reaction, cytotoxic index (CI) by complement dependent micro cytotoxic test, and anti idiotypic antibodies to blocking antibodies (BE Ab2) by MLR BE inhibiting test Results:204 cases of RSA were classified into 4 types on the basis of Immunological analysis ,including typeⅠ (lack of materno fetal immuno recognition), typeⅡ(materno fetal inappropriate immuno recognition), typeⅢ(disorder of materno fetal immuno recognition), type Ⅳ (unexplained) TypeⅠand type Ⅲshowed mainly lack of blocking antibodies, and accounted for 85 8% in population of RSA Comparing to typeⅠand typeⅣ, typeⅡand typeⅢ appeared to abnormal increase in auto antibodies and iso antibodies to incompatible blood group Conclusion:Immuno pathogenic classification of RSA may be of an important significance to choosing the clinical immuno therapeutics and improving treating effect

OBJECTIVETo study the effect of Buyang Huanwu Decoction (BHD), Xuefu Zhuyu Decoction (XZD), and Sijunzi Decoction (SD) contained serums on expressions of Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signals, lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), tumor necrosis factor-α (TNF-α), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and to explore possible anti-atherosclerotic mechanisms.

METHODSTwenty New Zealand rabbits were divided into 4 groups at random, i.e., the normal control group, the BHD group (6.7 g/kg), the XZD group (3.6 g/kg), and the SD group (1.6 g/kg), 5 in each group. All medication lasted for 7 successive days. Two h after the final medication, about 50 mL blood was withdrawn from rabbit heart for preparing serums. Human umbilical vein endothelial cell ECV304 were cultured in vitro for 18 h and randomly divided into the blank control group, the model group, the Western medicine (WM) control group, the BHD group, the XZD group, and the SD group at random. ECV304, except in the blank control group, were stimulated with lipopolysaccharide (LPS) for 2 h. Those in the WM control group and CM groups were treated respectively with corresponding CM contained serum for 24 h. Finally gene and protein expressions of TLR4, myeloid differentiation factor 88 (MyD88), tumor necrosis factor receptor-associated factor-6 (TRAF-6), NF-κB, LOX-1, TNF-α, ICAM-1, and VCAM-1 were detected by fluorescent quantitative PCR and Western blot.

RESULTSCompared with the blank control group, mRNA expressions of TLR4, MyD88, TRAF-6, NF-KB, LOX-1 , TNF-cx, ICAM-1, and VCAM-1 increased significantly; protein expressions of TLR4, NF-κB, LOX-1, TNF-α, ICAM-1, and VCAM-1 also increased significantly in the model group (P < 0.01). Compared with the model group, mRNA and protein expressions of each index could be significantly inhibited in the BHD group, the XZD group, and the WM control group (P < 0.05). Besides, mRNA and protein expressions of each index could be significantly elevated more in the BHD group and the XZD group than in the WM control group (P < 0.05). No statistical difference existed in each index between the SD group and the rest groups (P > 0.05).

CONCLUSIONSThe mechanism of BHD and XZD for fighting against atherosclerosis might be associated with inhibiting TLR4/NF-κB signal transduction pathway and expressions of its downstream inflammatory factors such as LOX-1, TNF-α, ICAM-1, and VCAM-1. But SD showed no associated effect on atherosclerosis.

Animals ; Atherosclerosis ; drug therapy ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Endothelial Cells ; Intercellular Adhesion Molecule-1 ; metabolism ; Lipopolysaccharides ; Myeloid Differentiation Factor 88 ; metabolism ; NF-kappa B ; metabolism ; Rabbits ; Scavenger Receptors, Class E ; Signal Transduction ; TNF Receptor-Associated Factor 6 ; metabolism ; Toll-Like Receptor 4 ; metabolism ; Tumor Necrosis Factor-alpha ; metabolism ; Umbilical Veins ; Vascular Cell Adhesion Molecule-1 ; metabolism

Objective To investigate the effect of ipratropium bromide combined with budesonide /formoterol fumarate inhalation powder on serum FeNO and lung function of bronchial asthma patients.Methods 102 cases with clear bronchial asthma during Jan 2013 and Mar.2015 from the affiliated Qianfo Hill Hospital of Shandong University were randomly divided into three groups, control group A (34 cases) were treated with ipratropium bromide, control group B (34 cases) were treated with budesonide/formoterol fumarate powder, experiment group (34 cases) were given ipratropium bromide combined with budesonide/formoterol fumarate powder, all groups were treated for 6 months.Pulmonary function, serum FeNO and IgE levels, clinical efficacy were compared after treatment.Results The effective rate of control group A, B (70.59%, 67.65%) were significantly lower than experiment group (91.18%), the difference were significant (P<0.05).FEV1, FVC, FEV1%pre of experiment group were significantly higher than control group A and B after the treatment.Serum IgE and FeNO concentration were significantly lower than control group A, B, the difference were significant ( P<0.05 ) .Conclusion Ipratropium bromide combined with budesonide/formoterol fumarate powder for inhalation in bronchial asthma patients can effectively reduce FeNO concentration, improve lung function.

It has been confirmed that tumor invasion and metastasis is not only dependent on the charac -teristics of the tumor ,but also dependent on the tumor microenvironment .Tumor-associated macrophage ( TAM) , which constitutes a large number of the tumor -infiltrating immune cells,is stimulated into M1 macrophage and M2 macrophage by different signals in the tumor microenvironment .Whereas the vast majority of studies with nu-merous tumor types show that the presence of M 2 phenotypes in the tumor microenvironment is associated with a worse prognosis ,most studies in gastric cancer also claim the same results .Hypoxia and coagulation factors may both contribute to it .It has identified that the function of TAM could be changed with their location of tumor ,but it has nothing to do with cell differentiation and cell type of gastric cancer .In this review,we summarize the differ-ent and controversial effects of TAM in gastric cancer .

Objective To study and investigate the comprehensive application value of urinary tract dilata-tion combined with cavity technique in patients with ankylourethria.Methods 70 male patients with ankylourethria were collected as the research object,and they were randomly divided into the control group(ordinary urethral dilata-tion treatment group ) of 35 cases and observation group (urinary tract dilatation combined with cavity technique group)of 35 cases by numeration table,then the treatment effect of different stricture length,urodynamic indexes and life quality state before and after the treatment of the two groups were evaluated and compared.Results The cure rates and recurernce rates of the observation group were 91.43% and 2.86%,respectively,which were better than that 68.57% and11.43% of the control group(χ2 =5.396,6.502,all P<0.05).The urodynamic indexes and life quality state at first,third and sixth month after the treatment were all better than those of the control group (t =4.613,4.902,5.263,3.180,all P<0.05).Conclusion The comprehensive application value of urinary tract dila-tation combined with cavity technique in patients with ankylourethria is higher,and it is more benefit for the improve-ment of urodynamic indexes and life quality state.

OBJECTIVE: To study the equilibrium solubility of aesculin and its apparent oil/water partition coefficient,and to provide basis for absorption mechanism study.METHODS: Equilibrium solubility of aesculin at the pH of 1.2～8.0 was determined by saturation method.The apparent oil/water partition coefficients of aesculin were determined by shaking flask method.RESULTS: The equilibrium solubility of aesculin at the pH of 1.2～6.8 was fluctuated slightly;it increased rapidly at the pH of 7.4;the maximum equilibrium solubility of aesculin was obtained at the pH of 8.0(10.58 g?L-1).The oil/water partition coefficient of aesculin changed slowly at the pH of 1.2～6.0;it decreased significantly at the pH of 6.0;the minimum oil/water partition coefficient was obtained at the pH of 8.0(0.03).CONCLUSIONS: The equilibrium solubility of aesculin and its apparent oil/water partition coefficient are associated with the pH of medium.The reason that aesculin has no effect on uric acid after oral administration is relevant to poor gastrointestinal tract absorption ability.

Blood blister-like aneurysms mostly originate from the non-bifurcation sites of the internal carotid artery.They have the characteristics of the aneurysm wall fragile and wide neck.Currently they were treated with neurosurgical procedures and endovascular interventional techniques.This article reviews the advances in the treatment of blood blister-like aneurysms of the internal carotid artery.