Signal transducer and activator of transcription 3 (STAT3) is an important member of the STAT family of signaling pro-teins. STAT3 is widely expressed in different types of cells and tissues and is involved in many physiological and pathological process-es, including cell growth, proliferation, apoptosis, and malignant transformation. Over recent years, increased attention has been given on the role of STAT3 in tumor angiogenesis and radiation sensitivity. Studies show that on the one hand, following activation, STAT3 promotes angiogenesis by directly regulating the expression of vascular endothelial growth factor and then causes radiation resistance. On the other hand, STAT3 indirectly promotes angiogenesis by activating hypoxia-inducible factor-1α(HIF-1α), thus producing radio-therapy tolerance. Moreover, STAT3 can directly or by HIF-1αindirectly regulate CyclinD1 expression, thus rapidly promoting cell pro-gression through G1 into the S phase of the cell cycle and enhancing cell proliferation. In addition to regulating the cell cycle, CyclinD1 plays a key role in radiation sensitivity. Results suggest that STAT3 plays a role in tumor angiogenesis and radiation resistance via di-rect and indirect mechanisms. In this review, we summarize recent research advances on the role of STAT3 in regulating tumor angio-genesis and radiation sensitivity.

Objective To improve the quality of medical image and enhance the image in range of frequency area.Methods Images were enhanced by adopting the arithmetic of Laplacian and Sobel,and using image multiplication and addition.The effects were compared.Results After being transformed in Laplacian,the interior frame of original image turned to be obvious and the original image was led into much noise simultaneously.In comparison with the former one,the image would be more smooth after being transformed by Sobel.Treated by average filter,the influence of noise and tiny detail would be reduced.Conclusion The toolbox of Matlab can simplify the program work,which provides a method for medical image processing.

The mature Wistar rats were fed with high lipid diet for 8 weeks together with 3 levels (30, 60, or 120mg/day) of dl-?-tocopheryl acetate supplementation. At the end of the experiment, serum vitamin E and lipids were measured by fluorescence analysis and enzymologic method, liver crude fat was measured by Soxhlet method, liver glycogen content and fat accumulation in parenchymal cells were estimated by histo-chemical procedure and liver lipid peroxidation was evaluated by fluorescence analysis respectively. The results showed that the high lipid diet induced hypercholesterolemia and fatty liver associated with a decrease in serum high density lipoprotein cholesterol and an increase in liver peroxidation. Overall vitamin E caused no significant decrease in serum cholesterol and triglyceride levels and no significant increase in high density lipoprotein cholesterol level, except serum vitamin E level had a positive correlation with serum cholesterol level, but could inhibit the neutral fat accumulation in liver cells and liver peroxidation in rats.The levels of serum cholesterol, or the serum vitamin E and VE/CHO were higher in females than those in males significantly when dl-a-tocopheryl acetate was given to the rats fed with high lipid diet.

Epigenetics consists of DNA methylation,post-translational modification of histon,microRNA and long non-coding RNA,which regulate angiogenesis by acting on different targets.Epigenetics has become potential targets of anti-angiogenesis in tumor.

Hypoxia results from long-term anti-angiogenic therapy and can stimulate hypoxia-inducible factors (HIFs). HIF-induced hy-poxia signaling is involved in various steps in tumor invasive-metastatic cascade. On the one hand, HIFs regulate epithelial-mesenchy-mal transition. On the other hand, the characteristics of pericytes around vessels and the links among endothelial cells can change;thus, tumor cells can more easily intravasate into blood vessels, survive in peripheral blood, and then reach specific organs, ultimately resulting in metastasis. This review discusses the emerging mechanisms of long-term anti-angiogenic therapy and the occurrence of metastasis.

Malignant tumor therapy has entered a new era ofprecise treatment.Nowadays, targeted anti-angiogenic agents have become a popular research topic that continues to attract increasing interest. Tumor immune escape plays an indispensable role in therapeutic resistance. Anti-angiogenic therapies not only prevent the tumor angiogenesis and suppress tumor growth but also neu-tralize tumor escape from a host's immune system by reducing the immunosuppressive cells and increasing the number of tumor-infil-trating lymphocyte (TIL) and cytotoxic lymphocte (CTL). This paper aims to review the mechanism underlying the manner by which an-ti-angiogenesis enhances immunity by influencing tumor microenvironment.

Objective To develop a set of software to manage war readiness material, such as the medical equipment, the medical material of medicine(consumables), the instrument, etc. Methods Based on the platform of PowerBuilder, management modules for equipment, consumables, medicine and others material were designed. Results Material data could be modified, added, reduced and queried in the corresponding module. Conclusion Changing the mode of manual management, the management level is raised, the waste is reduced and equipment can be repaired promptly.

Objective To explore the feasibility and efficacy of windowing middle meatus maxillary sinus and the frontal recess of tears to treat complex maxillary sinus under the nasal endoscope.Methods Clinical data of 22 patients with complex maxillary sinus lesions were analyzed retrospectively,which were adopted by the approach surgical treatment of through windowing middle meatus maxillary sinus and the frontal recess of tears.In which varus papilloma in 11 cases,5 cases of fungal maxillary sinusitis,3 cases of hemorrhagic and necrotic polyps,recurrent nasal polyps in 3 patients.After operation,they were all taken CT or MRI examination.Nasal cavity and other sinus lesions were first removed,the maxillary sinus ostium were opened through the nasal passages.Then,the maxillary sinus lesions were removed by the frontal recess of tears operation.Results Through the treatment of postoperative nasal cavity irrigation,these cases were followed up for 6 to 18 months.All cases incisions were healed completely,sinus cavity epithelium and clinical symptoms disappeared gradually.No injuries of nasolacrimal duct and complications such as facial numbness.Conclusion The method of the nasal passages joint the frontal recess of tears to treat the complex maxillary sinus benign lesions is a worthy selection of surgical procedures.Its eye shot is open and convenient operation,it can remove maxillary sinus lesions thoroughly and has fewer complications.

Objective:To investigate the change of the serum IL-18, sFas and sFasL levels in patients with severe burn and its correlation with the morbid condition and outcome Methods:Thirty patients, including three fatal cases, had burn with a total burn surface area (TBSA) of 30% or more 45 healthy volunteers were as control group The serum IL-18, sFas and sFasL levels were measured by enzyme-linked immunosorbent assay (ELISA) at various time points ( 1, 3, 5, 7, 14, 21, 28 and 35 days) burn later Results:Compared with control group, the levels of IL-18, sFas and sFasL of patients increased significantly after burn (P

Objective To evaluate RR,DCR,PFS,OS and toxicities in a population affected by NSCLC using gefitinib as maintenance therapy after the first line chemotherapy.Methods From January,2006 to January,2008,seventy-one patients were enrolled with stable disease or partial response after firstline chemotherapy.They were divided into the observing group and the control group.Gefitinib was administered at the dose of 250 mg in observing group;placebo was also administered everyday in control group.Results Of 71 assessable patients ,overall response rate was 36.1% (13/36) in observing group and 14.3 % (5/35) in control group respectively (x 2 = 4.633,P = 0.036),and one patient (2.8 %) was observed complete response (CR) in observing group.The disease control rate was 83.3 % (30/36) in observing group and 42.9 % (15/35) in control group,respectively,(x2 = 14.782,P ＜ 0.001).The median PFS (progression free survival time) was 13 weeks in observing group and 11 weeks in control group respectively (x2 = 10.401,P =0.001).The median overall survival time (OS) was 13.2 months in observing group and 10.4 months in control group respectively (x2 = 7.696,P= 0.006).The median OS was 18.5 months in women and 11.2 months in men(x2 =22.864,P=0.011) .The median OS was 15.3 months in non-smokers and 10.3 months in smokers (x2 =10.389,P =0.007).The median OS was 16.0 months in adenocarcinoma and alveolar cell carcinoma patients and 10.2 months in squamous cell carcinoma patients (x 2 = 4.638,P = 0.001).The most common toxicity was rash ,diarrhea,fatigue and dry skin itching,and most of them were 1 or 2 grade.Conclusion Maintenance therapy with gefitinib after first-line chemotherapy may improve overall survival time and progression free survival time in patients with NSCLC,and it is effective and safe.