0.05).There were statistical significant differences in the cellular immunity between the immunization and no-immunization group( P

Objective:To explore the influence of background data in multinutrient treatment for neonate with infection pneumonia. To study the relative risk factors in VA nutritional state. Methods:the orally vitamin A and vitamin E,zinc, selenite daily in 111 neonates in the randomized,double-blind, placebo-controlled,clinical Trial for 7 days treatment. We investigated and analyze the relevant biochemical,immune evidence, clinic data and background data, with multivariate stepwise regression analysis. Results:Mother’s age, parity,gestation age and birth weight play positive influence to clinical restoring. Neonate’s age and birth weight play a positive role to serum IgM in early stage of pneumonia,but mother’ s age is negativity. Neonate’s age is positivity in enhancing serum VA,and is negativity in advancing serum IgM. Mother’s age play a negative role to heighten serum RBP. Conclusion:Mother’s age,parity,gestation age and neonate’s age is important factors to influence the clinical treatment effect. Great age and many parity mother’s neonate,earlier period and large for date infant are more possible to VAD during sick period,and are more slow to recover. So they need the nutritional intervention all the better.

The ultrastructure of magnetotactic bacteria strain WD\|1 was reported.A thin sectioned profile of it clearly showed its cell wall,cell membrane,poly\|?\|hydroxybutyrates and magnetosomes.Meanwhile,the method of batch culture of strain WD\|1 was also reported,135mg/L dry cells could be gotten with this method.The energy profiles of X\|ray collected after electron excitation in SEM indicated that both dry cells and magnetosomes contained such mineral elements as P,S,Ca,Si,Al and Fe with different content.The iron content of its cells and magnetosomes was 3 07% and 84 57% respectively.

Objective:To determine the location of mycobacterium tuberculosis(MTB) and whether the cellular immunity is induced after intragastric administration of BCG in mice.Methods:Viable MTB were detected in mesenteric lymph nodes?spleen and lungs at day 15,30 and 60 after intragastric administration of BCG to mice.The proliferation of T-lymphocyte with the stimulus of the purified protein derivative(PPD) was measured at day 60 and 90 after intragastric administration of BCG to mice.The expression of interleukin-2(IL-2) of T-lymphocyte in spleen was detected at day 60 and 90 after intragastric administration of BCG.Results:Viable MTB were detected in the mesenteric lymph nodes and spleen at day 15,30 and 60 after intragastric administration.At day 60 and 90 after intragastric administration of BCG to mice,the ratio of T-lymphocyte proliferation was 31.32%,37.94% separately and the production of IL-2 was 37.47?5.60 U/ml,39.41?7.73 U/ml separately.There were no statistically significant differences in the cellular immunity between the mice of the intragastric administration of BCG significant differences in the cellular immunity between the mice of the intragastric administration and the mice of the subcutaneous vaccination of BCG( P 0.05).Conclusion:Intragastric administration of BCG can induce cellular immunity in mice.

We have observed the protective effects of indocin (IND), a potent inhibitor of pro-sglandins (PGs), on ototoxicity induced by furosemide (FU) using the synchronous recording technique of endocochlear potential (EP) and auditory action potential(AP) in guinea pigs. The FU group were found to have a mean decrease in EP of 65.1?5.6mV and AP amplitude 91.5?10.2%. In contrast, the animals in the FU+IND group had a much smaller reduction of EP(17.5 ?3.8mV) and AP amplitude(31.1?4.7%). The rate of return in EP and AP was much faster in the FU+IND group as compared with the other group. Our findings suggest that the ototoxicity of FU may be related to the mediation of PGs in the inner ear target tissues. IND can interrupt an increase in endogenous PGs in cochlear tissues triggered by FU injection by inhibiting the biological synthesis of PGs, thus effectively diminishing the ototoxicity induced by FU.

Objective:To compare clinical therapeutic effects of simple TCM and simple western medicines on ulcerative colitis.Methods:Randomized effect model of Meta-analysis was used for quantitatively combined analysis on research literature about simple TCM treatment of ulcerative colitis with controlled study of simple western medicine from 2000~2004 in China.Results:Of 744 cases in the simple TCM treatment group,698 cases were clinically effective,and among 493 cases in the western medicine control group,335 cases were clinically effective.The stable rate total OR(odds ratio)=6.60,95%CI was(4.60,9.47) in the simple TCM treatment group,with significant difference between the two groups (P

Objective To explore the role of Neuroretinal Rim Volume/ Rim Area(RV/RA) ratio in Early Diagnosis of Primary Open Angle Glaucoma(POAG).Methods All candidates were divided in to three groups(31～40 years old,41～50 years old,51～60 years old),Heileberg Retina Tomography(HRT)were used to test retinal disk,and the RV/RA ratio were calculated.Result There are obviously difference between nomal and POAG group in RV/RA(P

Clinically,peripheral nerve injury is common,treatment is still a clinical problem.Because of the peripheral nerve's particular dissection and the function,repair of its damage is a complex process,meticulous microsurgical technique can be used to restore nerve continuity,but the restoration of nerve function is still not satisfactory.Recently,the domestic and foreign scholars has made effort and achieved some success,particularly,the allograft nerve transplant has applied in clinical.

Objective To compare the influence of blood lipids and angina pectoris using combination therapy in coronary heart diseases(CHD) with unstable angina.Methods 100 patients were randomly divided into the probucol group(A group) 50 cases and probucol combined with atorvastatin treatment group(B group) 50 cases,The treadmill exercise ECG test,lipid and oxidation before and after treatment in two groups were observed.Results The total effective rate was 90.0% in group B significantly higher than 64.0% in group A(χ2 =3.841,P＜0.05);The total effective rate of ECG was 74.0% in group B after treatment which was significantly higher than the 42.0% in group A(χ2 = 3.981,P＜0.05);Treadmill exercise ECG test positive 82.0%,84.0% in two group before treatment,significantly higher than that 48.0%,24.0% in two group after treatment,(χ2 = 3.841,3.791,all P＜0.05);Angina pectoris in A、 B group after treatment [(1.6 ± 0.8) times、(1.0 ± 0.5) times]were significantly lower than [(4.3±1.9) times、(4.6 ±2.8) times]before treatment(χ2 =7.584,7.984,all P＜0.01).Conclusion Probucol was a safe and effective drug for treating hypolipidemic and reducing angina attack.Its combination with atorvastatin was safe,and the efficacy is more visible.

ObjectiveTo study the distribution and expression of NMDA receptor subunit 2A in the spinal cord of morphine tolerant rats. MethodsTwelve Sprague-Dawley rats were randomly divided into two groups with 6 rats each: control group (C) were intrathecally administrated 0.9% NaCl 10μl and morphine group(M) received 10μg morphine (i.t.). Drugs were administrated twice daily for 7 consecutive days. Tail flick latency (TFL) in the hot water immersion test was used to evaluate changes of thermal hyperalgesia latency of each group before and 30min after administration every morning. Rats were killed the day after last administration and L4～5 segment of the spinal cord was removed for determination the expression of NR2A by immunofluorescence method. ResultsTFL of group M was decreased gradually after chronic administration of morphine intrathecally. There was no significant difference between group M[(3.25±0.93)s] and group C[(2.66±0.27)s] on the 7th day (P＞0.05). A morphine tolerant model was established successfully. NR2A was distributed throughout the rat spinal cord. The expression of NR2A in group M(OD:9617±1233) was increased compared with group C(OD:2.66±0.93) (t=3.133,P＜0.05).ConclusionThe expression of NR2A was upregulated after repeated administration of morphine intrathecally in the superficial dorsal horn of spinal cord of morphine tolerant rats,which may be part of the mechanisms of morphine tolerance.