0.05).The relative bioavailability of experimental preparation vs.reference preparation was(93.80?12.24)%.CONCLUSION:Telmisartan capsule has the same bioe-quiavailability with telmisartan tablet.

Chronic overuse disease of the shoulder is very common in clinical practice.Its pathogenesis is complicated and its treatment is often a combination of medication,rehabilitation and surgery.In recent years,its diagnosis tends to be more definite,leading to more specific treatment.Extracorporeal shock wave therapy has been successfully used in the treatment of such orthopaedic diseases as plantar fasciitis and lateral epicondylitis,and has been tried by some scholars in the treatment of chronic overuse disease of the shoulder.Its therapeutic effect has also been demonstrated to some extent on calcific tendonitis,non-calcific tendonitis and adhesive capsulitis.This review outlines the progress in research of extracorporeal shock wave therapy for the treatment of chronic overuse disease of the shoulder.

Objective To study the effect of aspirin in the prevention of cardiovascular events for patients with hypertension.Methods 105 patients with hypertensive disease were randomly divided into group A,B,C, 35 cases in each group,and group A was dealed with nifedipine tablets treatment,group B were treated with nifedipine tablets and aspirin,group C was given nifedipine tablets and dipyridamole.The antihypertensive effects of the three groups were observed,three years through regular follow -up for all patients,the effects of prevention of cardiovascular events in patients with essential hypertension were observed.Results The occurrence probability of myocardial infarction,cerebral infarction and cerebral hemorrhage in the group B were 2.85%,2.85%,0.00%,respectively, which were statistically significant less than those in the group A and C group(F =19.4,P <0.05).Conclusion The preventive effect of aspirin is better for cardiovascular events in hypertensive patients,which is worthy to be popu-larized and used in clinical studies,aspirin for this kind of disease is a kind of ideal.

Objective To analyze reasons of common malfunctions of air compressor and the handling during the mechanical ventilation for elderly patients. Methods 87 cases of malfunctions of air compressor of ventilators from June 2005 to June 2007 were analyzed. Results unsteady pressure:31cases(account for 36%); low pressure: 28 cases (account for 32%), startup failure: 15 cases (account for 18%); dead halt: 13 cases (account for 14%). Conclusion Well grasping principles of the air compressor of ventilators, and timely & correct analysis of malfunctions reasons play key roles in solving all kinds of malfunctions associated with the air compressor of ventilators.

BACKGROUND:In recent years, the morbidity of chronic pancreatitis has been increasing dramaticaly with lifestyle changes. Fortunately, endoscopic pancreatic stenting for patients with chronic pancreatitis shows favorable clinical prospects.OBJECTIVE:To introduce the advantages and disadvantages of various stent materials and to review the development and clinical application of pancreatic stents.METHODS: With the key words of chronic pancreatitis, pancreatic stent in Chinese and English, respectively, a computer-based search was performed for articles published in CNKI and PubMed databases from January 2005 to November 2016. After the initial screening, articles related to endoscopic pancreatic stenting usedin vitro,in vivo or in clinic were included.RESULTS AND CONCLUSION: Endoscopic pancreatic stenting has become a recognized treatment for chronic pancreatitis in recent years. Therefore, the development and application of the materials of pancreatic duct stents appear to be particularly important. According to different materials, pancreatic duct stents can be classified into plastic stents, fully covered self-expandable metal stents, and biodegradable stents. The complications, including stent migration and secondary surgery, frequently appear in the clinical use of plastic pancreatic duct stents and self-expandable metal stents, although they have been widely used in clinical practice. Biodegradable pancreatic duct stents can be degraded completely in the pancreatic duct within the expected time, and thereby avoid several complications. Consequently, the exploitation and application of biodegradable pancreatic duct stents have become an issue of concern.

Objective To assess the value of hepatic venous pressure gradient in the evaluation of early postoper﹣ative hemorrhage after endoscopic esophageal varices ligation (EVL). Methods 120 cases of rebleeding after EVL from January 2014 to January 2015 as subjects. Collect and study clinical indexes such as the venous pressure gra﹣dient, then used logistic regression analysis method to analyze the threshold assessment. Results Drinking, hemor﹣rhage in early stage, bilirubin, heart rate, blood transfusion, child Pugh score and MELD score were significant dif﹣ferences (P< 0.05); HVPG=16.98 mmHg, for the prediction of rebleeding threshold, and in the time of the highest predictive accuracy. Conclusion The hepatic venous pressure gradient has an accurate evaluation value for early postoperative hemorrhage after endoscopic esophageal varices ligation.

Objective To investigate the mid-term outcome of high tibia osteotomy (HTO) combined with tibial tuberosity limited rotation in the treatment of disorder of patellofemoral joint with knee varus.Methods HTO was performed in all 42 patients.The lower limb alignment,lateral femoral tibial angle,medial proximal tibial angle,Q angle and TF-TG were measured before and after operation.All the patients with disorder of patellofemoral joint were divided into three types based on preoperative patellar trajectory and TF-TG.According to different types we chose the limided rotation of distal tibia through adjustment of tibial tubercle location to improve patellar track.Type Ⅰ in 10 cases and type Ⅱ in 12 cases only accepted HTO,type Ⅲ in 20 cases accepted HTO and tibial tubercle rotation.The rotation angle was determined according to preoperative imaging results and foot forward angle.Before and after operation patellar tilt angle,patellofemoral angle and lateral patellar angle were measured.Results 42 patients were followed up for more than 5 years,an average of 72.20± 12.60 months (60-88 months).No nerve damage,infection and bone nonunion occurred.The patellar tilt angle was improved from 12.45°±3.76° to 6.98°± 1.78° 5 years after operation.The patellofemoral angle was improved from 12.51°±4.71° to-4.70°±2.57° 5 years after operation,and the lateral patellar angle was improved from 1.50°±4.90° to 7.80°±3.10°.Preoperative lateral femoral tibial angle was improved from 182.45°±2.20° to postoperative 174.60° ±3.50°,medial proximal tibial angle was improved from preoperative 78.75°± 3.50° to postoperative 93.25°±1.95°.The Lysholm score was improved from preoperative 53.10±5.60 to 92.70±5.50.The preoperative IKDC subjective score was improved from 47.50±6.40 to 91.30±6.90.The Kujala score was 62.40±8.70 before operation and 87.30±4.10 5 years after operation.Visual analogue score (VAS) was 7.50±2.45 before operation and 1.50±0.90 5 years after operation.The short and mid-term follow-up,knee patellar trajectory and lower limb alignment was good,postoperative symptoms was satisfactory and acceptable.Conclusion HTO combined with limited rotation of the tibial tubercle could improve patellar trajectory and lower limb alignment to relieve pain,and has satisfactory mid-term outcome in the disorder of patellofemoral joint with knee yarus patients.

The late stages of the HIV-1 replication cycle are important to the overall replication cycle. During the late stages, HIV-1 replication undergoes the processes of assembly, release, and maturation, resulting in the production of a mature virus particle capable of infecting a new target cell. The structural protein Gag and its related gene (protein) play a central role in these pathways. The different regions of Gag worked in concert to drive production of a mature infectious particle through protein-protein, protein-RNA and protein-lipid interactions. The designed drug aimed directly at these stages can efficiently block the maturation and infectivity of HIV-1. In this article, the role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and related inhibitors is reviewed.

Solid phase microextraction(SPME) can be effectively used to extract volatile and semivoltaile organic compounds from different environmental matrix. In this paper, we utilize headspace-SPME technique combined with capillary gas chromatography (CGC) and a laboratory modified flame photometric detector using quartz surfaceinduced luminescence (QSIL-FPD) for analyzing butyltin compounds in sediments. The detection limits of mono-,di-, and tri-butyltin compounds, based on the signal equal to 3 times the baseline noise are 16.9 ng/g, 1.58 ng/g adn 0.17 ng/g, respectively.

Objective To explore the main points of early diagnosis,the principles and the efficacy of surgical treatment of Lisfranc injury.Methods The clinical data and follow-up results of 23 cases of patients with Lisfranc injury treated from April 2004 to February 2011 (17 males,6 females,aged from 19 to 57 years old) were collected and analyzed.All patients underwent open reduction and internal fixation,among them,13cases with Kirschner wire fixation and 10 cases with screws fixation.Efficacy was evaluated in accordance with Maryland foot score.Results Twenty-one patients were followed up for 6 - 46 months with an average of (28.5 ± 2.6) months.In the last follow-up no patients has internal fixation fracture,loss of reduction and other complications.The score was 56 - 97 points with an average score of ( 86 ± 8 ) points.The results showed excellent in 6 cases,good in 10 cases and fair in 3 cases,good rate was 76.2％.Conclusion Lisfranc injury can be diagnosed by early signs and symptoms,and can be confirmed by combining with radiographic examination.Lisfranc injury should be treated with open reduction and internal fixation with Kirschner wire or screw,both of the two fixation methods can achieve good results.