Objective To investigate the imaging features of the calvarial cavernous hemangioma and the surgical efficacy to improve diagnosis and treatment of the calvarial cavernous hemangioma.Methods The clinical information,imaging materials and surgical efficacy from ten cases of calvarial cavernous hemangioma confirmed by pathology and the related literature was reviewed.Results The lesion was located in frontal bone in eight cases,in parietal bone in one case and in occipital bone in one case.The lesions were round-shape hypodensity with clear margin in X-ray.The lesions were hyperdensity or slightly hyperdensity on CT scan,and were osteolytic lesions with a characteristic honeycomb or starburst pattern on bone window.The MRI features were complicated and variable.The lesions were heterogenous and unevenly enhanced signal intensity.Nine patients underwent radical resections and reconstructed immediately by titanium mesh.The patient with tumor in occipital bone underwent radical resection only.Macroscopically,the pathologic bone was a huge purple-red blush mass protruding from the skull surface.Histological examination revealed the diploe with large,thin-walled,dilated blood-filled spaces lined by flattened endothelial cells without evidence of malignancy.No recurrence was noted in any case during a follow-up period from 3 to 24 months.All the patients survived well without recurrence.Conclusions The imaging features of calvarial cavernous hemangioma have a high value in the diagnosis and may provide guidance for the treatment.The radical resection and immediate reconstruction treatment for calvarial cavernous hemangioma is satisfied.

目前，癌症患者的存活率及无病生存率持续提高，但是肿瘤复发率依然较高。肿瘤复发与肿瘤细胞的休眠及耐药有 着密不可分的内在联系。骨髓具有丰富的血管和营养，因此也是原发肿瘤远处转移的主要场所之一。当肿瘤细胞转移到骨髓 内，可以与骨髓内的基质细胞相互作用，并触发肿瘤细胞休眠，休眠状态下的肿瘤细胞不仅可以存活很长的时间，而且对细胞毒 性治疗顽强抵抗；最重要的是在特定的条件下，还可恢复增殖，最终引起肿瘤复发。其中，成骨细胞、间充质干细胞和部分细胞因 子促进肿瘤细胞的休眠，破骨细胞和神经元细胞主要参与肿瘤细胞休眠的停止和转移的发生，而内皮细胞促进肿瘤细胞增殖或 是休眠取决于周围环境的活化状态。本文就上述内容的研究现状做一简要综述。