Objective:To prepare loxoprofen sodium sustained release pellets, and investigate the in vitro drug release behavior. Methods:Loxoprofen sodium loaded pellets were prepared by extrusion-spheronization technology, and the sustained release pellets were prepared with Eudragit RL 30D and Eudragit RS 30D as the sustained release coating film materials. The drug release behavior of loxoprofen sodium sustained release pellets in vitro was studied. Results:Eudragit RL 30D and Eudragit RS 30D with the ratio of 20 ∶80 was used as the sustained release coating film materials, the coating weight was 20%, the plasticizer content was 10%, and the content of talc was 45%. The in vitro release of loxoprofen sodium from the sustained release pellets was steady and entire in 12 h. Conclusion:The release behavior of loxoprofen sodium sustained release pellets is quite satisfactory. And the preparation technology may be used in the industrial production.

Burns ; Evidence-Based Medicine ; Humans

Anterior Cruciate Ligament ; surgery ; Anterior Cruciate Ligament Injuries ; Anterior Cruciate Ligament Reconstruction ; methods ; Humans ; Knee Injuries ; surgery

Animals ; Burns ; physiopathology ; therapy ; Genetic Engineering ; Humans ; Hyperbaric Oxygenation ; Tissue Engineering ; Wound Healing

Evidence-Based Medicine ; Humans ; Resuscitation ; Shock ; therapy

Type 1 diabetes, a complex genetic disease, is determined by both genetic and environmental factors. After excluding the five susceptibility loci discovered by genetic linkage studies and candidate-gene association studies, more than 30 new susceptibility loci have been found to be related with type 1 diabetes as a result of genome-wide association study.

Objective To investigate the common pathogenic bacteria distribution and drug resistance in children with lower respiratory tract infection,which guide how to use antibiotics and decrease the progress of drug resistance.Methods Nine hundred and ninety-seven cases of lower respiartory tract infection were analyzed retrospectively in the Department of Pediatrics of the First Hospital of Lanzhou University from Jan.2008to Dec.2010.The sputum samples were collected for routine bacterial cultivation.The antibiotic sentivity test were used for pathgen.Results The phelm cultivition amount is 997,bred and separated 498 bacteria of 425samples,the check rate is 42.73％.There were 151 Gram Positive Bacteria,which had a rate of 30.32％,and 321 Gram Negative Bacteria,which had a rate of 64.46％,and 26 fungi whose rate is 5.62％.The main bacteria was changed during the three years.There were significant differences in detection rate of pseudomonas aeruginosa(PA) and haemophilus parainfluenzae(HPI) during the three years.PA was declining while HPI was rising.There were no significant differences in detection rate of streptococcus pneumoniae( SP),staphylococcus aureus ( SA),escherichia coli( E.coli ),klebsiella pneumoniae ( K.pn ),haemophilus influenzae ( HI ) and fungi.There were no significant differences in detection rate of PA between different age groups.With the increasing of age,the detection rate of SP,HI and HPI trended to rise,whereas the detection rate of SA,E.coli and K.pn trended todecline.The resistance phenotype of SA,E.coli and HPI in detection rate had significant difference in each year.SP and SA were most sensitive to linezolid and vancomycin.Ecoli and K.pn were most sensitive to carbapenems.HI and HPI were relatively sensitive to common antibiotics.Conclution In the past three years,the main pathogen in children with lower respiartory tract infection were Gram Negative Bacteria.Among the bacteria,SP and Ecoli was the most,followed by SA,HI,K.pn,and HPI.These bacteria had signifeicant difference in dectection rate between different age groups.SP and SA were most sensitive to vancomnycin and linezolid.E.coli and K.pn were most sensitive to carbapenems.HI and HPI were relatively sensitive to common antibiotics.So clinical doctors should use antibiotics based on the microorganism cultivation and sensitivity test m order to decrease the drugresistance strain.

Biology-related disciplines in medical school of comprehensive university are cur-rently confronted with some difficulties, including unclear position and indistinguishable characteris-tics. In this paper, we proposed that biology-related disciplines in medical school of comprehensive university should center on disease research, emphasize medical feature and give full play to its tech-nical advantage thus to provide technical support for basic medicine and clinical medicine. Mean-while, sources of multiple disciplines should be effectively integrated by breaking through the limitation of discipline and administrative system. An interdisciplinary molecular medicine platform was built up for researching and teaching.

Objective This study was performed to find the association of the severity of coronary artery disease with ordinary risk factors for CHD and left ventricle heart function in patients with CHD. Methods Selective coronary angiography were carried on 305 consecutive patients admitted to our hospital from December 2008 to April 2009. The severity of coronary disease was accessed by the Gensini scoring system. These patients were divided into two groups, patients with CHD group (251 cases) and control group (patients without CHD) (54 cases) , to compare the difference of ordinary risk factors for CHD between the two groups. Multiple linear regression analysis was used to analyze the association of the severity of coronary artery disease with ordinary risk factors for CHD. We also used linear correlation analysis to investigate the association of the severity of coronary artery disease with left ventricle ejection fraction in patients with CHD. Results The two groups had statistically difference on age, sex, smoking index, hypertension prevalence rate, serum glucose abnormal prevalence rate, diabetes prevalence rate, and metabolic syndrome prevalence rate( P < 0.05). We found that age (β_1 =0.251, P <0.01), sex (β_2 =0.235, P < 0.01), LDL-C concentration (β_3 = 0.241,P <0.01), duration of diabetes (β_4 =0.226, P <0.01) went into multiple linear regression model. We also found the severity of coronary artery disease had a negative correlation ( r = -0. 362, P <0.01) with left ventricle ejection fraction in patients with CHD. Conclusion When we decide to cany out coronary angiography on susceptible patients, we should consider their age, sex, smoking index, whether had hypertension, serum glucose abnormal, diabetes, metabolic syndrome or not. Age, sex, LDLC concentration, duration of diabetes affect severity of coronary artery stenosis independently. Left ventricle ejection function will decrease as coronary atherosclerosis continues.

Professor Dai Yuguang is good at treating many kinds of internal diseases.He thinks that the nasopharyngeal carcinoma is intimately connected with five viscera and two fu-large intestine and small instestine.Cold phlegm obstructs the lucid yang to get to nasopharynx.Radioactive rays burn the body fluid and interferes with zang-fu organs’ function.The poison of chemotherapy medicine is harmful to qi and blood,and blocks the transportation and transformation of the middle energizer.So,the principle to solve the problem is relieving the branch-aspect in acute cases;the methods include clearing away heat to remove toxin,replenishing qi and nourishing yin,etc.In the same time,to treat primary cause,dissipate phlegm and dredge orifices are needed.