In recent years,with the deepening research on autoinflammatory diseases (AID),more and more diseases have been found and included in the AID category.The clinical manifestations of AID are various,but most of them are not specific.Therefore,it is difficult to distinguish AID from infectious diseases,tumors and other autoimmune diseases,which causes misdiagnosis and delayed diagnosis.This article aims at discussing about the clinical diagnosis and treatment procedure of AID.

Spontaneous abortion is one of the most common gestational conditions, with the morbidity of 1% to 5% in married women. It is a serious problem troubling women at the reproductive age. There are many factors causing spontaneous abortion, among them, spontaneous abortion resulting from endocrine abnormalities can be detected and treated. Prolactin is a major endocrine hormone participating in reproductive regulation and playing an important role in early pregnancy implantation and pregnancy maintenance. When there are unusual levels it is closely related to spontaneous abortion, leading to a necessity to further study the relationship between them. International and domestic research developments in recent years about the correlation between prolactin and spontaneous abortion are discussed in this paper.

Abstracting and Indexing as Topic ; Academic Dissertations as Topic

The atrio-ventricular valves of the normal heart in 200 Chinese cadavers of different ages were studied. The right atrioventricular valves were classified into three types and the left were classified into two types, according to the number of the main cusps. It was found that percentage of the second type (53.5%) of the right atrio-ventricular valves was higher than that of the first type (43.5%) and the first type (83.0%) of the left atrio-ventricular valves is in the majority, while the second type (17.0%) represents only a small percentage.An accessory cusp is situated between two main cusps. The accessory cusp was found in the right atrio-ventricular valves of 132 cases (66.0%), the majority of which had only one accessory cusp (95 cases. 72.0%), and among them there were 65 cases (37.4%) in which antero-medial accessory cusps were present. The accessory cusps were found in the left atrio-ventricular valves of 103 cases (51.5%), most of them also had only one cusp (92 cases 89.3%) and among them there were 71 cases (62.3) in which postero-medial accessory cusps were present.If the total number of the main and the accessory cusps was considered, in the right ventriculus, four cusps were found in 40.5% of the cases, five in 29.0%, three in 19.5%, six in 9.0%, two in 1.5%, seven in 0.5%; while in the left ventriculus, three cusps were found in 51.5% of the cases, two in 37.0%, four in 11.0% and five in 0.5%.The size of the valves was measured. In the right ventriculus the postero-medial valve is the broadest (40.1 mm), the postero-lateral valve is the highest (24.5 mm). In the left ventriculus the postero-lateral valve is the broadest (36.9 mm), the antero-medial valve is the hightest (20.8 mm). The associated valves are usually larger than the other common main valves, the diameters of which are larger than that of the accessory valves. The perimeter of left artrio-ventricular ring is 79.69 mm and the right is 97.79 mm.

OBJECTIVE:To provide reference for the rational use of TCM injections. METHODS:The related data of using TCM injections was drawn from May 2009 to May 2014. And the data of 5 TCM injections,including Shengmai and Shenmai in-jection,were statistically analyzed,the indications of 8 TCM injections,including Shengmai and Shenmai injection,were also sta-tistically analyzed. RESULTS:In solvents evaluation,the 5 TCM injections were used 501 times,in which 391 times(78.04%)of the solvents used were rational,381 times(76.05%)of the solvent doses used were rational;in clinical indications evaluation,the 8 TCM injections were used for 2 579 patients,in which 1 120 cases were in accordance with the instructions while the other 1 459 cases were not,the qualification ratio was 43.43%. CONCLUSIONS:There were still some problems in using TCM injection in our hospital in the aspects of solvent as well as indications.

Objective To investigate the effect of creating caring group on the caring ability of undergraduate nursing students,and to put forward strategies for cultivating the caring ability of undergraduate nursing students.Method A total of 80 nursing freshmen who provided voluntary informed consent to participate in the study were divided into 2 groups.Students in the control group were taught with routine teaching mode,while the students in experimental group were recruited to caring group on the basis of control group's routine teaching.Caring group were conducted team activities regularly,which included topic discussion,experience sharing,interest games and team report so on.The experimental group and control group were surveyed by Caring Ability Inventory (CAI) during the beginning,middle and the end period of the research.SPSS 20.0 was used for data processing and the data was made descriptive analysis,t test,and analysis of variance.Results Before the intervention,the CAI total scores of the experimental group and the control group were (184.55 ± 13.25) and (186.67 ± 25.11) respectively and there was no statistically significant difference on the total score and scores in three dimensions.Compared with the norm of foreign countries,the caring ability of the students was at middle and low level.The scores of experimental group and control group in the cognitive dimension increased with higher grade,but there was no statistically significant difference between two groups.The two groups' scores in patience and courage sub-scales also increased with grade level and experimental group had significant higher scores than control group in the two sub-scales (P＜0.05).Conclusion Caring ability of undergraduate nurs-ing students in our school is low.Caring group can effectively improve students' caring ability.Nursing students' caring ability cultivation strategies need to be explored.

Purpose To investigate the presence of perineural invasion (PNI) and the expression of human epidermal growth factor receptor 2 (HER-2) in patients with advanced gastric cancer.To discuss the correlation between PNI and the expression of HER-2 and their prognostic significance.Methods Paraffin sections of surgical specimens from 100 patients who underwent gastric resection were selected,and then PNI were detected by HE staining and the expression of HER-2 were detected by immunohistochemical (IHC).The correlation of perineural invasion with the clinicopathological features and HER-2 expression were performed.Results PNI was positive in 42 cases of 100 patients (PNI positive rate was 42％),the occurrence of PNI has significantly related with lymph node metastases,infiltrating depth,tumor emboli,TNM stage and expression of HER2.The difference was statistically significant (P ＜ 0.05).Univariate analysis showed that total survival rate of advanced gastric cancer was associated with T stage,tumor emboli,N stage,TNM stage,PNI and HER-2 expression (P ＜ 0.05).The overall survival of the PNI-negative patients was 45.3 months on average,much better than the PNI positive patients who was 15.4months in average (P ＜ 0.05).The overall survival of the HER2-negative patients was 43.2 months on average,much better than the HER-2-positive patients who was 22.7 months in average (P ＜ 0.05).By muhivariable Cox proportional hazards model of overall smvival,the positivity of PNI and HER-2 appeared to be new independent prognostic factors (P ＜ 0.05).Conclusion The detection of PNI and HER-2 expression maybe helpful for the prognosis of patients with advanced gastric cancer.In addition,HER-2 may be responsible for the presence of perineural invasion.

Objective To further study the pathogenesis for congenital heart disease (CHD) and connective tissue growth factor(CTGF) for the early diagnosis of CHD and pulmonary hypertension (PH).Methods Sixty-six cases of children with CHD were selected from the thoracic surgery who were performed in the Children's Hospital of Shanxi Province during the period between Sep.2012 and Jan.2013.Based on the cardiac color Doppler estimation of the pulmonary artery systolic pressure,they were classified into several groups:unincorporated PH group with 16 cases,mild PH group with 18 cases,moderate PH group with 17 cases,and severe PH group with 15 cases.Based on types,the 66 cases could be classified as ventricular septal defect (VSD) group with 23 cases,atrial septal defect (ASD) group with 17 cases,patent ductus arteriosus(PDA) group with 14 cases,and composite(including 2 or more of the congenital cardiovascular anomalies) group with 12 cases.Twenty healthy children who had medical examination over the same period in the Children's Hospital of Shanxi Province were randomly chosen as the healthy control group.The serum concentration of CTGF in the research objects were determined with the aid of double antibody sandwich enzyme-linked immunosorbent assay method.According to the different pulmonary artery systolic pressure and different types of CHD,the serum concentration of CTGF were compared among groups.The correlation of between the CTGF concentration in the serum and pulmonary artery systolic pressure were also analyzed among the groups of children with CHD.Results Quantitative measurement revealed that the serum CTGF concentration measured in the groups of children with CHD were significantly higher than that in the healthy control group(P ＜ 0.05) ; the serum CTGF concentration of the children with CHD and PH was higher than that in the group of children with CHD alone(P ＜ 0.05).With the increase in pulmonary artery pressure,CHD patients serum levels of CTGF also increased(P ＜ 0.05).By the correlation analysis,the results showed that the serum level of CTGF in the CHD groups were positively correlated with the pulmonary artery pressure (r =0.670,P =0.005 ; r =0.514.P =0.029 ; r =0.517,P =0.034 ; r =0.707,P =0.003).The difference in terms of serum CTGF concentration in different types of CHD patients was not significant (F =0.270,P =0.847).Conclusions There exists certain damage in CHD early myocardial fibrosis(unincorporated PH),when combined with PH,myocardial fibrosis increases with the gradual increase of pulmonary artery pressure.However,the degree of myocardial fibrosis shows no correlation with the type of CHD.

Gastric cancer is a malignant tumor with the second highest incidence and mortality in the world, and China is one of the countries with the highest incidence of gastric cancer in the world. Research on the regulation of cell cycle protein can provide effective evidence for the mechanism of tumor and gene therapy.G1/S phase is the key point for cell cycle regulation,Cyclin D1 and CDK4 gene and P16 play important roles in this phase and have great correlation with gastric cancer,but the exact relationship between these genes and gastric cancer is still unclear. In order to better understand the expression of Cyclin D1 and CDK4 gene and P16 in gastric cancer, the related researches in recent years were summarized in this paper.

This study was aimed to explore the tic disorders ( TD ) pathogenesis induced by chronic rhinitis . A total of 400 TD children were all investigated with self-made TD general questionnaire , Yale Global Tic Severity Scale ( YGTSS ) , TD diagnostic criteria by DSM-IV , chronic rhinitis diagnostic criteria by Zhu-Fu-Tang Textbook of Pediatrics ( 7th edition ) . A total of 258 TD children accompanied with chronic rhinitis were screened . Levels of peripheral blood T lymphocyte subsets , immunoglobulins , IL-6 , TNF-α and other related immunological indexes were detected to analyze pathogenesis. The results showed that the nose movement symptom scores of TD children with rhinitis were higher than the score of TD children without rhinitis . The score of arm-lifting and hand movement in TD children with rhinitis was lower than the score in the TD children without rhinitis . And the YGTSS score of TD children with rhinitis was higher than TD children without rhinitis. Compared with TD children without rhinitis, the level of peripheral blood T lymphocyte subsets in TD children with rhinitis was obviously reduced ( P < 0 . 05 ) . Compared with TD children without rhinitis , the level of immunoglobulins in TD children with rhinitis was slightly reduced . The level of IL-6 in TD children with rhinitis tended to increase , but the level of TNF-α tended to reduce . It was concluded that chronic rhinitis is one of the factors to induce TD .