BACKGROUND: Clinical study of insomnia is performed by monitoring the alpha wave of the brain signals with the polysomnography (PSG). PSG has two deficiencies in recording electroencephalogram (EEG): ①The testee is wrapped by long electrode wires so that they cannot sleep normally. As a result, the testee's mental and physical status is affected and the results are inaccurate. ②As the alpha wave consists of very weak biomedical signals, it is easily affected by the alternating current (AC) interference, so that the analytical software cannot identify the desired signals. For these reasons, a monitoring system that overcomes such deficiencies is needed. OBJECTIVE: To design a wireless EEG sensors system for detecting brain signals. It can obtain the brain signals in an accurate and non-disturbed way without affecting the testee's mental and physical status. DESIGN: The actual application circuit was implemented after analyzing and building the circuit model. SETTING: The 305 Hospital of Chinese PLA.MATERIALS: The clinical experimental environment was provided by the 305 Hospital of Chinese PLA. The PSG made by Beijing Rising Sun Science-Tech Co., Ltd. was served as experimental instrument for comparison test and analytical software was designed by MATLAB.METHODS: Theoretical analysis was performed at the 305 Hospital of Chinese PLA in 2005 to create the anti-interference model and the wireless EEG sensors system model. In 2006, the circuit model helped us realize the small-sized wireless brain wave sensor that could suppress the interference effectively. The sensor was put into practical use at the 305 Hospital of Chinese PLA from February to August 2006. The experiment was approved by the hospital ethics committee. The volunteer testees were those who worked in the hospital and they had full knowledge of the objective, process and results of the experiment. Besides, those signals were compared with what the PSG recorded. MAIN OUTCOME MEASURES: Frequency spectrum of signals obtained in interference environment. RESULTS: For the brain signals that were captured by the wireless EGG sensors in the presence of interference, the power spectrum peak value was 6 926.043 within the alpha wave ranged at 8-12 Hz. For the AC interference, the power spectrum peak value was 0.356 at 50 Hz. Meanwhile, for the brain signals that were captured by the PSG, the power spectrum peak value was 1112.3 within the alpha wave ranged at 8-12 Hz; for the AC interference, the power spectrum peak value was 85 440 at 50 Hz.CONCLUSION: The system can obtain satisfying brain alpha wave signals and can suppress AC interference effectively.

BACKGROUND:In some clinical applications or special work conditions,extremely intonse 50 Hz AC intefference exists.As the amplifier's output reaches or is close to saturation,it cannot be suppressed by general anti-interference circuits or software algorithms.Themfore,the hardware circuit must be impreved to suppress this interference,thus obtajning the desired signals.OBJECTIVE:To introduce a biopotential amplifier,which can effectively suppress the impact of 50 Hz AC interference on the weak biomedical signals.DESIGN:Create a circuit model based on the advanced theoretical analysis,then make software emulation and finally design the actual circuit implementation.SETTINGS:the 305 Hospital of Chinese PLA:Institute of Aviation Medicine,Air Force of CIIinese PLA.MATERIALS:The experimentaIinstruments and analytical software were provided by the Institute of Aviation Medicine,Air Force of Chinese PLA:the high-voltage electrical field environment was provided by the 305 Hospital of Chinese PLA.METHODS:The first step was theoretical analysis at the Institute of Aviation Medicine,Air Force of Chinese PLA in 2005,then the 50 Hz anti-reference model was created.After that,the following three anti-reference measures were put forward:①Enhancing the common-mode input impedance of the overall circuit to remove the interference caused by the imbalance electrode impedance;②reducing the equivalent common mode input impedance of the instrument amplifier in the circuit by using a current source controlled by the comlnou mode voltage;③using the driven-right-leg circuit to reduce the common mode voltage.Moreover,emulation analysis was made for the above circuit model by using the circuit emulation software TINA PRO.Through ceaseless improvement of the circuit model,the correct emulation results were obtained.In 2006,the Circuit model helped us realize the electrocardiogram(ECG)amplifier that could suppress the 50 Hz AC intefference effectively in intense interference environments.And that amplifier was put into practical use in the high-voltage electrical field environment produced by the high-voltage electrical field treatment equipment in the 305 Hospital of PLA.The result was satisfying:the 50 Hz AC interference was suppressed effectively and the high-quality ECG signals were obtained.MlAIN OUTCOME MEASURES:Common-Mode Rejection Ratio(CMRR)and the frequency spectrum of signals obtained in intense intefference environment,which are used to assess the ability against the 50 Hz AC interference.RESULTS:A 100 ù resistor or a 200 kù resistor were connected in series in the input loop so as to produce the imbalance electrode impedance status.When the imbalalice electrode impedance was 100 ù,the amplifier output was 1.69 Mv,and CMRR was 125.8 Db.When the imbalance electrode impedance was 200 k ù,the amplifier output was 1.78 Mv,and CMRR was 125.3 Db.Two voltage sources(20 Hz,amplitude of peak to peak value 50 ì V,opposite phases)were used to produce differential mode signals.The amplification gain was 1000 times.In the input loop of the circtilt mentioned above,a 200 kù resistor was connected in series to create the inabalance electrode impedance status.The amplifter output the peak-to-peak value 50 Mv.The fast Fourier transform(FFT)frequency spectrum of the output wave contained no 50 Hz spectrum line.CONCLUSION:Through the emulation experiment and the real application.we can all find that the amplifier has good signal amplification performance and anti-interference capabillty in intensive 50 Hz AC interference environments and severe imbalance electrode impedance Status.

Objective To investigate impact of abnormal slucose metabolism on major adverse cardiac event in patients after coronary artery stent implantation.Methods Two hundred and fifteen patients whose data were available were enrolled in this study,and the patients were divided into 3 groups,diabetes group(group A),abnormal glucose metabolism group(group B),normal glucose tolerance group(group C).The clinica,coronary artery lesion characteristics and major adverse cardiac event(MACE)rate during in hospital and follow up periods were compared.Resuits There was a higher occurrence of MACE in group A and group B than that in group C(P＜0.01).There was no significant difference between group A and group B.Conclusion The patients of coronary heart disease with abnormal slucose metabolism have higher MACE rate than abnormal slueese metabolism.

Laparoscopic basic skills training is an inevitable requirement of minimally invasive surgery.Minimally invasive surgery department in the fourth affiliated hospitals of Harbin medical university launched lectures on basic theory and knowledge of laparoscopy,combined simulation training with surgery observation applied flexible teaching methods so that students can truly master the techniques of minimally invasive surgery.

Objective To explore the effect of low dose of dexamethasone and mannitol on the early swelling of oral and maxillofacial injuries.Methods A total of 100 patients with oral and maxillofacial injuries who were treated in Huanggang City Center Hospital from February 2015 to January 2016 were divided into two groups by means of an envelope randomized group.Group 50 patients, group A patients received low doses of dexamethasone treatment, B group of patients on the basis of increased mannitol for treatment, compared the efficacy of both groups of patients with maxillofacial swelling improved.Results The clinical general improvement probability of group B was significantly higher than that of group A, and the distance between the horizontal direction and the vertical direction of group B was significantly higher than that of group A (P<0.05).Conclusion The combination of low dose dexamethasone and mannitol has a great effect on the early swelling of oral and maxillofacial injury, and it is worthy to be further implemented in the future clinical practice.

Objective To observe and analyze the clinical effects of joint injection therapy, ultrashort wave physical therapy and oral medication on temporomandibular joint osteoarthritis. Methods From September 2014 to September 2016 in Huanggang central hospital of Hubei province, 120 patients with osteoarthritis of the temporomandibular joint were divided into 3 groups according to the different treatment methods, 40 cases in each group. The injection group were treated with a joint cavity injection, The ultrashort wave group were given ultrashort wave physiotherapy, and the drug group were given oral medication. The effects and the temporomandibular joint function (DI) values were compared in the 3 groups at 1, 3 and 6 months after treatment. Results 1 months after treatment, the total effective rate in the injection group was 92.50%, 90%in the ultrashort wave group, and 72.50% in the drug group. The total effective rate in the injection group and the ultrashort wave group were better than that in the drug group (P<0.05); 3 and 6 months after treatment, the total effective rate was 90% and 95% in the injection group, which were better than those in the other 2 groups (P<0.05); DI value in the injection group was (0.17 ±0.04), (0.18±0.03), which were significantly better than the other 2 groups (P<0.05). Conclusion The effect is better which joint cavity injection was used in the treatment of temporomandibular joint osteoarthritis. It has good stability and is worthy of further popularization and application

Drugs, Chinese Herbal ; therapeutic use ; Evidence-Based Medicine ; Humans ; Medicine, Chinese Traditional ; Quality of Life ; Treatment Outcome

China ; Complementary Therapies ; organization & administration ; Humans ; International Cooperation ; National Institutes of Health (U.S.) ; Research ; organization & administration ; United States

Objective To evaluate modified Soave procedure for the treatment of Hirschsprung's disease for the neonate and infant. Methods Seventeen cases of short and sigmoid types of Hirschsprung's disease were treated by transanal modified Soave procedure. The incision was made 1cm posterioly and 2-3 cm anterioly above the dental line; the dissection progressed from the submucosa layer up to the perineal reflex into the pelvic cavity, and the rectum was pulled through. "V" shap muscular cuff was excised on the posterior wall. The proximal colon was anastomosed to the anal mucosa. Results Mean operative time was 160 min ? 45 min, mean blood loss was 45 ml ?35 ml. No enterocolitis, anastomotic leak, perianal infection and anastomotic stenosis occurred. All patients recovered with normal defecation, and no complication was observed from a follow-up of more than 4 mos. Conclusion Modified Soave procedure is safe and effective for the treatment of Hirschsprung's disease in the neonate and infant.

Core fucose glycosylation catalyzed by α1, 6-fucosetransferase(Fut8) is an important way for protein post-translational modification and functional regulation; it directly influences a series of biological characteristics of cells and is always seen under some pathological conditions. This paper reviews the recent studies on the regulation, biological function of Fut8 and its relationship with different kinds of tumors.