3.Idiopathic Rice Bodies In Painless Knee Swelling: A Case Report
Manas FF ; Ismail II ; Ab Halim MA
Malaysian Orthopaedic Journal 2018;12(Supplement A):255-
4.Personalised management of Chronic Obstructive Pulmonary Disease (COPD): Malaysian consensus algorithm for appropriate use of inhaled corticosteroid (ICS) in COPD patients
Nurhayati Mohd Marzuki ; Mat Zuki Mat Jaeb ; Andrea Ban ; Ahmad Izuanuddin Ismail ; Irfhan Ali Hyder Ali ; Mohd Razali Norhaya ; Azlina Samsudin ; Mona Zaria Nasaruddin ; Rozanah Abd Rahman ; Mohd Arif Mohd Zim ; Razul Md. Nazri B Md Kassim ; Yoke Fong Lam ; Aishah Ibrahim ; Noor Aliza Mohd Tarekh ; Sandip Vasantrao Kapse
The Medical Journal of Malaysia 2020;75(6):717-721
Background: Regarding the long-term safety issues with the
use of inhaled corticosteroids (ICS) and the clinical
predominance of dual bronchodilators in enhancing
treatment outcomes in chronic obstructive pulmonary
disease (COPD), ICS is no longer a “preferred therapy”
according to the Global Initiative for Chronic Obstructive
Lung Disease except on top of a dual bronchodilator. This
has necessitated a change in the current therapy for many
COPD patients.
Objective: To determine a standardised algorithm to
reassess and personalise the treatment COPD patients
based on the available evidence.
Methods: A consensus statement was agreed upon by a
panel of pulmonologists in from 11 institutes in Malaysia
whose members formed this consensus group.
Results: According to the consensus, which was
unanimously adopted, all COPD patients who are currently
receiving an ICS-based treatment should be reassessed
based on the presence of co-existence of asthma or high
eosinophil counts and frequency of moderate or severe
exacerbations in the previous 12 months. When that the
patients meet any of the aforementioned criteria, then the
patient can continue taking ICS-based therapy. However, if
the patients do not meet the criteria, then the treatment of
patients need to be personalised based on whether the
patient is currently receiving long-acting beta-agonists
(LABA)/ICS or triple therapy.
Conclusion: A flowchart of the consensus providing a
guidance to Malaysian clinicians was elucidated based on
evidences and international guidelines that identifies the
right patients who should receive inhaled corticosteroids
and enable to switch non ICS based therapies in patients
less likely to benefit from such treatments.
5.Abolition of Beauty Marks – Calamitous Burn
Saw Shier Khee ; Shawaltul Akhma Bt Harun Nor Rashid ; Norzila Ismail ; Michael Pak-Kai Wong
Malaysian Journal of Medicine and Health Sciences 2022;18(No.1):369-371
We present a case series of two young women presented with facial chemical burns after applying the mole removal
products. In this series, we describe the potentially corrosive active ingredient that produces the chemical burn in the
natural product and the off-label or unauthorised product. The burn on the delicate facial skin leads to irreversible
disfigurement. However, with timely wound debridement and a full-thickness skin graft, the reconstruction can still
achieve a satisfactory aesthetic result.
6.Traumatic Hemipelvectomy: Salvage Or Sacrifice?
Din MH ; Nik Hassan NN ; Razali MF ; Wan Ismail WF
Malaysian Orthopaedic Journal 2018;12(Supplement A):251-
7.Women in Orthopaedics: A Perspective from Malaysian Female Orthopaedic Surgeons
Liew SK ; Lee JA ; Tamam F ; Ismail II ; Mohamed-Saaid F ; Chye PC
Malaysian Orthopaedic Journal 2023;17(No.1):70-78
Introduction: The awareness of under-representation of
female surgeons in orthopaedics has been increasing in this
decade. We aim to investigate the reasons why female
surgeons chose orthopaedic, the barriers that possibly hinder
female surgeons into orthopaedics and analyse the obstacles
that they encountered in their career in Malaysian context.
Materials and methods: A total of 101 registered female
orthopaedic surgeons registered with the Malaysian Medical
Council, during the period 1980 to 2020, were contacted for
a cross-sectional survey, consisting of thirty-four questions
on their experience in the orthopaedic career. Eighty-two
responses were received (81.2%). Questions in this survey
consisted of four sections: (1) demographic details, (2)
current clinical practice environment, (3) orthopaedics
training experience, and (4) career experience.
Results: A total of 49% of respondents had subspeciality
training, highest in paediatric orthopaedic (30%). Enjoyment
of manual tasks (64.6%) and professional satisfaction
(64.6%) were the top reasons for choosing orthopaedic as a
career. Primary barriers to orthopaedic were physical
strength required (56.0%) and public gender bias (52.4%).
Twenty-eight percent reported gender discrimination in
career opportunities while 60% reported similar in daily
work. Thirty-three percent reported verbal and 11% physical
sexual harassment in their career. Forty-four percent of
respondents reported benefits as female orthopaedic surgeon
in their work.
Conclusion: The reasons for Malaysian female orthopaedic
surgeons to choose orthopaedic as their career and the
barriers perceived to hinder other females from choosing
orthopaedics were similar to reports worldwide with no
exception to gender discrimination and sexual harassment.
The support given by male colleagues to married female
surgeons marked a unique phenomenon in Malaysian
culture.
8.Comparison between density gradient centrifugation method, an extended version of the horizontal swim up method and the combination of both for sperm selection
Malak JAMIL ; Hasnae DEBBARH ; Amal KABIT ; Mohamed ENNAJI ; Loic KOUMBA ; Ismail KAAROUCH ; Mohamed ZARQAOUI ; Wassim Rhazi SENHAJI ; El Mehdi HISSANE ; Brahim SAADANI ; Pierre VANDERZWALMEN ; Nourredine LOUANJLI ; Rachida CADI
Obstetrics & Gynecology Science 2023;66(3):221-229
Objective:
To compare the degree of efficiency between density gradient centrifugation (DGC) method and an extended horizontal swim-up (SU) method.
Methods:
A total of 97 couples undergoing in vitro fertilization were enrolled in the study. Semen samples were divided into three aliquots and treated using DGC, extended horizontal SU, and combined methods. DNA fragmentation and chromatin decondensation were detected in native semen samples and their three corresponding aliquots. The corresponding mature oocytes of each semen sample were divided into two sibling cultures. The first sibling culture was microinjected with semen pellets from DGC, and the second sibling culture was microinjected with semen pellets from the combination of both methods. Fertilization rate and embryonic development were assessed at day 3.
Results:
DNA fragmentation and chromatin decondensation was significantly low in DGC and extended horizontal SU samples; however, the rates of DNA fragmentation and chromatin decondensation were significantly lower in extended horizontal SU samples than in DGC samples. The lowest rates of DNA fragmentation and chromatin decondensation corresponded to the samples treated with both methods. The highest rates of DNA fragmentation and chromatin decondensation corresponded to the samples treated with DGC. No significant difference was found in the fertilization rate or day 3 embryos between sibling cultures.
Conclusion
The combination of DGC and the extended horizontal SU techniques is best for giving the lowest rates of sperm DNA fragmentation and chromatin decondensation.
9.Fatal subarachnoid haemorrhage in a patient with severe dengue
Seng Wee Cheo ; Qin Jian Low ; Eng Kian Ng ; Yuen Kang Chia ; Giri Shan Rajahram
The Medical Journal of Malaysia 2021;76(1):107-109
Dengue fever is one of the commonest tropical disease in
the tropics. It can present with mild acute febrile illness to
severe organ failure. Reported neurological complications
of dengue include dengue encephalopathy, encephalitis,
transverse myelitis and intracranial haemorrhage.
Intracranial haemorrhage in dengue can present as subdural
haematoma, extradural haematoma, intracerebral
haemorrhage and subarachnoid haemorrhage. We report
here a case of subarachnoid haemorrhage in a patient with
severe dengue. Our patient was a 30-year-old man who
presented with acute febrile illness. He subsequently
developed plasma leakage and upper gastrointestinal
bleeding. He then had reduced conscious level. Computed
tomography of his brain showed subarachnoid
haemorrhage. He eventually succumbed to his illness.
10.The Incidence and Variation of Corona Mortis in Multiracial Asian: An Insight from 82 Cadavers
Khirul-Ashar NA ; Ismail II ; Hussin P ; Nizlan NM ; Harun MH ; Mawardi M ; Lingam R
Malaysian Orthopaedic Journal 2024;18(No.1):26-32
Introduction: Corona Mortis (CMOR) is a term used to
describe an anatomical vascular variant of retropubic
anastomosis located posterior to superior pubic ramus. We
aim to provide sufficient data on the incidence, morphology
and mean location of ‘crown of death’ in Asian population.
Other objectives include to assess the relationship between
CMOR incidence with gender, race and age.
Materials and methods: This is a cross-sectional cadaveric
study involving 164 randomly selected fresh multiracial
Asian hemipelves (82 cadavers). Hemipelves were dissected
to expose and evaluate the vascular elements posterior to
superior pubic rami. Data were analysed using Chi-Square, ttest and with the help of IBM SPSS Statistics v26 software.
Results: CMOR was found in 117 hemipelves (71.3%). No
new morphological subtype was found. The mean distance of
CMOR to symphysis pubis was 54.72mm (SD 9.35). Based
on the results, it is evident that precaution needed to be taken
at least within 55mm from symphysis pubis during any
surgical intervention. The lack of statistically significant
correlation between CMOR occurrence and gender, race and
age suggest that the incidence of CMOR could be sporadic in
manner.
Conclusion: We conclude that CMOR is not just aberrant
vessel as the incidence is high and this finding is comparable
to other studies. The mean location of CMOR obtained in
this study will guide surgeons from various disciplines in
Asia to manage traumatic vascular injury and to perform a
safe surgical procedure involving the pelvis area.