Reversible splenial lesion syndrome (RESLES) is frequently observed in encephalitis or encephalopathy
caused by various pathogens such as influenza virus A, rotavirus, and measles. It is also associated
with epileptic seizures, anti-epileptic drug withdrawal and neuroleptic malignant syndrome. We report
here a Sri Lankan woman with RESLES associated with anti-NMDAR antibody encephalitis and
neuroleptic malignant syndrome.