1.HLA-B*1502 and carbamazepine induced StevensJohnson syndrome/toxic epidermal necrolysis in Indonesia
Herlyani Khosama ; Astri Budikayanti ; Amy Hui Ping Khor ; Kheng Seang Lim ; Ching-Ching Ng ; Indra G Mansyur ; Alida Harahap ; Teguh AR Ranakusuma ; Chong Tin Tan
Neurology Asia 2017;22(2):113-116
Background & Objective: Association between HLA-B*1502 and carbamazepine-induced StevenJohnson
syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian
populations but not in Indonesian. The purpose of this study was to evaluate the association between
HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of
CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was
performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502
was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035).
Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.
Result Analysis
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