● AIM: To demonstrate the operative technique and surgical outcome of using perfluorocarbon liquids (PFCL) in internal limiting membrane (ILM) peeling of eyes with macular hole associated with retinal detachment.● METHODS: The study consists of 8 consecutive eyes of 8 patients diagnosed to have total retinal detachment (RD) with macular hole between December 2001 and October 2002.The age ranged from 13 to 65 years (mean 39 years). The male female ratio was 5:3. Four eyes were in Non-myopic Group and 4 eyes in Myopic Group. The patients underwent vitrectomy, ICG dye to stain the ILM,PFCL to flatten the retina intraoperatively, ILM peeling,fluid air exchange and endolaser was performed around the peripheral breaks. Tamponade with either silicone oil or C3F8was used.● RESULTS: The follow-up ranged from 6 to 9mo (mean 6.5mo). In Non-myopic Group. Macular hole was completely closed at the end of follow-up in 3 eyes (75%)and decreased size with flat edge in 1 eye (25%). In Myopic Group. All 4 eyes had successful closure of macular hole at the end of the follow-up. Comparing the groups,complete closure of macular hole was achieved in 7 eyes (88%) and open hole with flat edge was seen in 1 eye (12%) at the end of follow-up.● CONCLUSION: Using PFCL is helpful in the peeling of ILM for macular hole associated with retinal detachment.