Objective:To evaluate the safety of epidural Innovar during upper epidural anesthesia. Method: Fortyeighty patients of breast surgery were divided randomly into 3 groups. Epidural anesthesia was used in control group. Fentanyl 1?g/kg and droperidol 0.05mg/kg were administered intravenously 30 minutes after the epidural injection of local anesthetics in intravenous group. Fentanyl 1?g/kg and droperidol 0.05mg/kg were given epidurally combined with the local anesthetics in epidural group, Respiration,hemodynamic and blood analysis changes were observed in the three groups before and during anesthesia. Result:The decrease of respiratory rate and increase of PaCO_2 were more significant in intravenous group than those in control group. There was no significant change of respiratory rate,but increases of PaCO_2 in epidural group, which was higher than that in control group and lower than that in intravenous group. Conclusion: Small dose of Innovar used epidurally has less influence on the respiration than the same dose of Innovar used intravenously during the upper epidural anesthesia.