Objective To summarize the experience of surgical treatment of congenital heart diseases combined with infective endocarditis. Methods All the patients of congenital heart diseases combined with infective endocarditis who received the surgical treatment in our department from January 1995 to December 2001 were retrospectively reviewed,which including 28 cases of single malformation and 11 cases of complex malformations. Results There were 3 early postoperative deathes, and the mortality rate was 7 7%. Followed up 5 months to 5 years with a mean of 3 6 years, there was 1 case of recurrent endocarditis and not late death. Conclusions Congenital heart diseases with infective endocarditis is an absolute surgical indication, and early surgical treatment of congenital heart diseases will lower the incidence of infective endocarditis.