OBJECTIVE:To probe into the occurrence characteristics of the adverse drug reactions(ADR) in Lanzhou area and to intensify the reporting,monitoring and management of ADR.METHODS:A retrospective analysis was performed on 345 valid ADR cases.RESULTS:The ADR reports were mainly submitted by medical institutions,account for 88.70%.The clinicians and hospital pharmacists were the chief reporting personnel.16 drug categories totaled 143 varieties were involved in the ADR,leading the list were traditional Chinese medicine preparation that account for 48.70%and antibacterial drugs that account for 29.86%.CONCLUSION:The reporting and monitoring of ADR should be intensified so as to decrease the rate of missing report and incidence of ADR to a large extent.

OBJECTIVE:To discuss the prevention and cure of anaphylactic shock caused by trasylol.METHODS:The anaphylactic shock was statistically analyzed among3862cases that were given slight dosage of trasylol before operation by intravenous drip.Among which,82cases had anaphylactic shocks,which accounted for2.12%of the total.RESULTS&CONCLUSION:The incidence rate of anaphylactic shock from trasylol by intravenous drip is quite high,thereby preparation of prevention and emergency treatment should be ready.

Objective To assesment the effect of risk factors at gestational diabetes mellitus (GDM).Methods We collected 427 pregnant women who had done 75 g oral glucose tolerance test (OGTT) between September 1st,2012 and April 19th,2013 in Peking University First Hospital,including 74 pregnant women diagnosed as GDM (GDM group) and 353 pregnant women undiagnosed (non-GDM group).Then we conducted a multiple logistic regression to analyze the clinical datas collected from two groups,which included age,pre-pregnancy body weight and body mass index (BMI),body weight during 11-12 weeks pregnancy,body weight during 23-24 weeks pregnancy; and fasting plasma glucose(FPG),triglyceride (TG),total cholesterol (TCH),high density lipoprotein (H DL),low density lipoprotein (LDL),fasting insulin (FINS),homeostasis model assessment of insulin resistance (HOMA-IR) during early pregnancy; and family history of diabetes mellitus.Results (1)There were significant difference in age,pre-pregnancy BMI,and FPG,TG,FINS,HOMA-IR during early pregnancy,and family history of diabetes mellitus between two groups (P ＜ 0.05).(2) The risk factors of GDM that have statistical significance included FPG during early pregnancy (OR:4.03,95 ％ CI:1.62-10.02),family history of diabetes mellitus (OR:3.15,95 ％ CI:1.66-5.99),TG during early pregnancy (OR:2.13,95 ％ CI:1.17-3.87),BMI before pregnancy (OR:1.36,95 ％ CI:1.08-1.70),age ≥ 35 years (OR:1.15,95 ％ CI:1.05-1.26),early pregnancy weight gain (OR:1.20,95％ CI:1.06-1.35),mid pregnancy weight gain (OR:1.28,95％ CI:1.12-1.47),FINS during early pregancy (OR:1.09,95％ CI:1.01-1.17).Conclusions FPG,TG and FINS during early pregnancy,BMI before pregnancy,early and mid pregnancy weight gain,family history of diabetes mellitus and age≥35 years are the indepadent risk factors for GDM.We should pay more attention to FPG and TG during early pregnancy,and put weight management into practise since early pregnancy and try to control pregnancy weight gain within reasonable limits.

OBJECTIVE:To provide reference for improving the rational use of antibacterial drugs in hospital.METHODS:Various measures were taken by clinical pharmacists to interfere with the clinical application of antibacterial drugs.RESULTS & CONCLUSIONS:Rational use and standard management of antibacterial drugs in hospital can be achieved by taking a series measures such as enhancing clinical pharmacists' own quality,pharmacists' participating in clinical medication management at the right moment,strengthening cooperation among different departments and bringing pharmacist' specialty advantages into full play.

Objective To observe the analgesic effect and safety of dezocine used in the periextubation period in pediatric pa-tients undergoing cleft lip and palate repair surgery under general anesthesia .Methods 60 American Society of Anesthesiologists (ASA ) grade Ⅰ - Ⅱ pediatric patients undergoing elective cleft lip and palate repair surgery under under general anesthesia in the central anesthesia department from January 1 to August 1 ,2013 were selected and randomly divided into group D ,F and N ,20 cases in each group .All the cases were performed the endotracheal intubation general anesthesia .At 15 min before the end of operation , the group D was intravenously injected by dezocine 0 .10 mg/kg ,the group F by fentanyl 1 .00 μg/kg and the group N (control group) by the isodose normal saline .The mean arterial pressure(MAP) and heart rate(HR) in all groups were recorded before in-duction ,extubation and at 5 min after extubation respectively .The extubation time ,Riker sedation-agitation scores and face ,legs ,ac-tivity ,cry and consolability(FLACC) scores at 30 min after extubation ,occurrence rates of various complications within 30 min after extubation(breathing and circulation depression ,nausea and vomiting ,drowsiness ,headache and extrapyramidal reactions were ob-served and recorded .Results The three groups completed the operation successfully .There were no significantly differences in age , body weight ,operation time and sevoflurane inhalation concentration among the three groups (P>0 .05) .HR and MAP in extuba-tion and at 5 min after extubation in the group D were lower than those in the group N and F(P<0 .05) ,but HR and MAP in extu-bation and at 5 min after extubation had no statistically significant difference between the group D and F (P>0 .05) .There was no statistically significant difference in the extubation time among 3 groups(P>0 .05) .The Riker sedation-agitation scores and the FLACC scores at 30 min after extubation in the group D were significantly lower than those in the group N and F with statistically significant difference( P< 0 .01 ) .Adverse reaction such as respiratory inhibition ,nausea ,vomiting ,lethargy ,headache ,vertebral body reaction were not found in the 3 groups after 30 minutes .Conclusion Dezocine used in pediatric patients with cleft lip and pal-ate repair surgery is safe and effective .

Overweight or obese women have a significantly increased risk of gestational diabetes mellitus (GDM). With the increasing prevalence of obesity among women of reproductive age, the prevalence of GDM has also risen. The prevention of GDM during pregnancy is particularly important in reducing the adverse pregnancy outcomes for both mothers and their offspring and decreasing the economic burden of the society. Lifestyle interventions (exercises, dietary), dietary supplementation, and pharmacological approaches are the main preventive measures. Exercise intervention and myo-inositol supplementation are effective in preventing GDM; dietary intervention and combined lifestyle intervention have some benefits, but the results remain controversial; probiotic supplementation and prophylactic use of metformin seem to be ineffective; the effectiveness of vitamin D supplementation is unclear.

Objective:To observe the effects of 0.4 μg/(kg·h)dose of dexmedetomidine on intra-operative wake-up test in children patients undergoing scoliosis surgery.Methods:Sixty patients for pos-terior scoliosis correction (ASA Ⅰ -Ⅱ,aged 5 -16 years)from March 2013 to April 2015 were en-rolled in this prospective,double-blinded,randomized,placebo-controlled study,The patients were ran-domly classified into two groups to receive dexmedetomidine (group RD,n =30)or saline solution (group R,n =30).In group RD,dexmedetomidine [0.4 μg/(kg·h)]was administered after tracheal intubation,while the equal volume saline solution was given instead in group R.Anesthesia was induced with midazolam,propofol,sufentanyl and cisatracurium,and anesthesia was maintained with sevoflurane inhalation and a continuous intravenous infusion of remifentanil in the both groups.BIS(bispectral index, BIS)value was maintained at 40 -60,and mean arterial pressure (MAP)was maintained at ≥ 60 mm-Hg before the wake-up test.When the wake-up test was performed,immediately the dexmedetomidine and remifentanil infusion were stopped,and the end-tidal concentration of sevoflurane was adjusted to 0. Mean arterial pressure,and heart rate (HR)were recorded before anesthesia and at 5-minute intervals during the wake-up test.The wake-up test time,arousal quality and sedation scores were recorded also. In addition,the data were also gathered on the dosage of ephedrine and atropine were used,as well as the intraoperative awareness in the patients who were followed up on the first day after the operation.Re-sults:There were no differences between group RD and group R with regard to HR and MAP at getting into the operation room (t =-1.460,P =0.150; t =-1.015,P =0.315 ).In group RD,no evi-dence was found for a difference in HR and MAP at awakening up versus at getting into the operation room (t =0.974,P =0.340;t =-1.449,P =0.161),while in group R,an increase in HR and MAP occurred at awakening versus at getting into the operation room (t =-2.106,P =0.044;t =-2.352, P =0.026).There were no significant differences in sedation scores and wake-up test time between the two groups(t =1.986,P =0.052;t =0.392,P =0.697).The wake-up test quality was significantly bet-ter in group RD than in group R (t =-2.098,P =0.041).HR in group RD was significantly lower than that in group R at any time point during the wake-up test (P <0.05).Four patients had awareness oc-currence during the operation in group R,and no awareness occurrence in group RD.Conclusion:Dexmedetomidine,when administered at a rate of 0.4 μg/(kg·h)as an adjuvant of sevoflurane inhala-tional anesthesia,could improve the wake-up test quality,and maintain hemodynamic stability during scoliosis surgery.

To improve the AIDS's knowledge level and intervention ability of peer lecturers in college, from the accumulation idea and activity type of experience value on Moso Teach, the author carried out systematic resource construction around the course design principles and objectives, at the same time one quantitative scoring system including learning degree and sharing degree was constructed. Through voluntary enrollment and selection among the students, the first group of peer lecturer training on AIDS prevention were set up, and 28 students were collected to experience the "mixed" application of the course. After the evaluation, it was found that there were positive functions in promoting the ability of AIDS prevention in the peer lecturer training course based on experience value of Moso Teach as the driving force and quantification. According to the problems exposed in the construction, the author put forward improvement strategies from the aspects of scoring system, off-line activities and resource optimization.

Objective To evaluate the maternal age at delivery in Beijing and the effect of maternal age on pregnancy outcomes.Methods A retrospective analysis was conducted on 14 970 singleton pregnancies from 15 hospitals in Beijing from June 20th to November 30th in 2013.These hospitals were sorted by the numbers of delivery and chosen as clusters by systemic cluster sampling method.The data of age,diagnosis with gestational diabetes mellitus (GDM) and pre-eclampsia (PE),neonatal birth weight,gestational age at delivery,postpartum hemorrhage and infants admitted to the neonatal ICU (NICU) were collected.The 14 970 women were divided into 5 groups according to their ages at delivery:(1) less than 20 years (n=205),(2)20-＜30 years (n=9 228),(3)30-＜35 years (n=4 365),(4)35-＜40 years (n=1 017),and (5) 40 years and older (n=155).T-test and x2 test were used for between-group comparison,and logistic regression analysis was used to examine the association between age and the risk of adverse pregnancy outcomes.Results (1) The mean maternal age at delivery in 2013 in Beijing was (28±4) years old.Among them,205 (1.4％,205/14 970) delivered under 20 years of age;1 172 (7.8％,1 172/14 970) ≥35 years;and 155 (1.O％,155/14 970) at 40 years and older.(2) The prevalence of diabetes,hypertension,overweight and obesity increased with age,and the incidence of these conditions were 3.4％,4.3％ and 31.4％ in women with advanced age,respectively.(3) Compared with 20-＜30 years group,less than 20 years was associated with significantly lower incidence of GDM [adjust OR (aOR)=0.393,95％ CI:0.222-0.696] and cesarean section rate (aOR=0.549,95％CI:0.391-0.771),and higher incidence of preterm birth (aOR=2.144,95％CI:1.256-3.662).Moreover,30-＜35 years,35-＜40 years and 40 years and older groups all had significantly higher risk of GDM (30-34 years,aOR=1.513,95％CI:1.374-1.666;35-＜40 years,aOR=2.094,95％CI:1.786-2.455;≥40 years,aOR=2.174,95％CI:1.492-3.167),preterm birth (aOR=1.219,95％CI:1.021-1.455;aOR=1.644,95％CI:1.251-2.161;aOR=2.141,95％CI:1.209-3.792),cesarean section (aOR=1.373,95％ CI:1.268-1.486;aOR=2.960,95％ CI:2.550-3.435;aOR=4.332,95％CI:2.920-6.426) and NICU admission rate (aOR=1.236,95％CI:1.059-1.443;aOR=1.337,95％CI:1.018-1.756;aOR=2.389,95％CI:1.385-4.121),when compared to the 20-＜30 years of age group.Higher incidence of PE (aOR=1.292,95％CI:1.007-1.659) and postpartum hemorrhage (aOR=1.224,95％CI:1.048-1.429) were also noted in women of 30-＜35 years,compared to 20-＜30 years group respectively.Conclusion Both advanced maternal age and adolescent pregnancy are associated with increasing risk of adverse pregnancy outcomes.

Objective To study the maternal and fetal outcome in pregnancy with overt diabetes. Methods Retrospective study was made on 88 pregnancies with overt diabetes from 1981 to 2001 in department of Obstetrics & Gynaecology, first teaching hospital, Beijing university to study the maternal and fetal outcome in pregnancy with overt diabetes and its relationship with the level of blood glucose. One case with artificial abortion and 2 cases with metaphase induced labor were rejeceted from the 88 cases, we devided the other 85 cases into two groups. Group A with well controlled glucose had 42 cases; group B without well controlled glucose had 43 cases. Results In this study, we found 5 cases of fetal death in group B, 3 of them were perinatal death. Nine cases of newborn malformation were all found in those people without well controlled glucose in early pregnancy, the incidence of newborn malformation was 10.2%. The rate of asphyxia of newborn in group B (24.4%) is significant higher than in group A (4.8%) ( P =0.011). The rate of pregnancy induced hypertension in group B (44.2%) is significantly higher than that in group A (21.4%) ( P = 0.026). The rate of premature labor in group B (30.2%) is significantly higher than that in group A (9.2%) ( P =0.017). Conclusions Maternal blood glucose with ideal control throughout pregnancy may reduce the maternal complications and perinatal morbidity and mortality in pregnancy with overt diabetes.