Objective To investigate the value of the combination of hs-CRP and WBC in infectious high risk infants. Methods 68 infants with infectious high risk factor were divided into high risk group,while 32 normal infants were in control group.Serum hs-CRP level and WBC were measured in the two groups. Results There were 54(79.4%)infants with serum hs-CRP level higher than 3 mg/L in high risk group,while just 8 infants in control group.Significant difference were found between the two groups(x2=27.344,P＜0.01).There were 21(30.9%)infants with WBC higher than 20 × 109/L.No significant difference was found between the two groups(P＞0.05).Serum hs-CRP and WBC were both abnormal in 21 infants with infectious experience,9 infants were diagnosed with neonatal infection. Conclusion Combination measurement of serum hs-CRP level and WBC were useful in early diagnosis of neonatal infection.