1.Diterpene constituents of Tripterygium willfordii (II).
Sui LIN ; Huiqing QUE ; Huayi PENG ; Liping QIAN ; Shunmin GUO ; Yuanchao LI
Acta Pharmaceutica Sinica 2011;46(8):942-5
In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2alpha-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).
2.Chemical constituents of Melastoma dodecandrum(Ⅱ)
Sui LIN ; Yuanchao LI ; Yuyu GUO ; Shunmin GUO ; Huiqing QUE ; Yiping QI
Chinese Traditional and Herbal Drugs 1994;0(08):-
Objective To study the constituents in Melastoma dodecandrum.Methods The constituents were isolated by chromatographic methods,and their structures were elucidated by spectroscopic evidences.Results Five compounds were purified and their structures were identified as: daucosterol(Ⅰ),oleanolic acid(Ⅱ),avicularin(Ⅲ),3,7,4′-trimethoxyquercetin(Ⅳ),and atractylenolidone(Ⅴ).Conclusion Compound Ⅴ is a new chemical constituent named atractylenolidone.Compound Ⅳ is isolated from M.dodecandrum for the first time.
Result Analysis
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