ObjectiveTo observe the effects of nasal continuous positive airway pressure(NCPAP) on neonatal respiratory disease.Methods67 newborns with respiratory disease undergone the treatment of NCPAP and routine clinic treatment.The changes of blood gas index and therapeutic effects were observed.The changes of blood gas between the pretherapy and post-treatment were compared.ResultsThe numerus of PaO2,SpO2 was increased apparently at 1 hour after treament with NCPAP.The difference was significant ( t =3.84,15.50,all P ＜ 0.05 ).But the PaCO2 had no apparent change and the difference was not significant(t =1.96,P ＞ 0.05 ).54 newborns were treated successfully and 13 newborns were treated unsuccessfully.51 newborns were cured,11 newborns were improved and 1 patient was dead at Last.ConclusionThe early application of NCPAP on neonatal respiratory disease was very effective.It could reduce the use of mechanial ventilation,and it was a convenient,safe and effect-prominent method.

Toll-like receptor( TLR) ,which belongs to pattern recognition receptor,is type I transmem-brane glycoprotein. TLR activates natural immune and induces several cytokines. Foreign studies have showed that bacterial infection is closely related with TLR. In this paper,the relationship between TLR and bacterial in-fection is reviewd.

Objective To investigate the mechanism of anti-aging effect of Yangyan Quban particles on the aging skin. Methods With the dose of D-galactose 1000 mg/(kg?d) by sc administration to the female mice for 42 days, the aging model was established. The mice received Yangyan Quban particles (6.68, 3.34, 1.67 g/kg) by ig administration at the same time of injecting D-galactose. Forty-two days later, the dorsal skin samples were collected to determine glutathione peroxidase (GSH-Px) activity and serum estradiol (E2) contents, and the influence on uterus, ovary, skin dry and wet weight and the amount of water intake were studied. Results Compared with the aged model mice, the GSH-Px activity and E2 contents in the mice treated with Yangyan Quban particles were increased remarkably, especially the medium is the best dose (P

Objective:The purpose is to observe the clinical results of the continuous douche and negative pressure drainage technic in treating the large hypodermal infected lacuna. Methods: The simple mini-size perfusion cannula for continuous douche and negative pressure drainage was handmade and used on 23 patients suffering from large hypodermal infected lacuna. Results: All of the 23 patients achieved primary healing from large hypodermal infected lacuna. Conclusion:The use of self-made mini-size perfusion cannula for continuous douche accompanied with negative pressure drainage is a good method to treat large hypodermal infected lacuna. It is very economic、efficient and easy.

The status quo of pain,trigger mechanism of pain,the manner of pain valuation and painalleviating measures during wound dressing were analyzed by checking literatures at home and abroad.These studies implied that the dressing-related pain impacted not only wound healing but also patients' daily life.At the same time,the studies and clinic practice of dressing-related pain in China were relatively deficient,therefore it is important that clinic practitioner should pay more attention to awareness of dressing-related pain and pain causes and take measures to relieve pain.

Objective To observe and analyze the clinical effect of aerosol inhalation with budesonide suspension liquid drug in the treatment of children with acute infectious laryngitis.Methods 76 children with acute infectious laryngitis were divided into the observation group (n=38) and control group (n=38).Two groups of chil-dren were treated with conventional therapy,on the basis of conventional therapy,the control group was given dexam-ethasone aerosol inhalation,the observation group was treated with atomization of inhalation with budesonide suspen-sion liquid.The clinical therapeutic effects of the two groups were assessed.Results The total effective rate of the observation group was 97.37%,which was significantly higher than 76.32% of the control group,the difference was statistically significant (χ2 =19.392,P<0.05).The disappeared time of fever,cough,hoarseness,dyspnea,throat beep symptoms in the observation group was (2.21 ±1.12)days,(2.21 ±0.54)days,(1.21 ±0.33)days,(1.61 ± 0.81)days,(1.23 ±0.21)days,which were significantly shorter than the control group,the differences were statisti-cally significant (t=4.118,4.362,6.369,3.943,3.946,all P<0.05).The two groups had no obvious adverse reac-tion,The duration and hospitalization time of the observation group were (2.11 ±0.72)days,(3.09 ±0.54)days respectively,which were significantly shorter than the control group (t=4.966,5.795,all P<0.05).The satisfaction rate of the observation group was (91.23 ±4.52)%,which was significantly higher than the control group,the differ-ence was statistically significant (χ2 =4.203,P<0.05).Conclusion For the children with acute infectious laryngi-tis,inhalation with budesonide suspension liquid therapy can significantly improve clinical symptoms,with no adverse reaction,shorten the course of disease and hospitalization time,reduce the physical and psychological suffering of chil-dren,improve the clinical treatment effect,promote the healthy growth of children,it is worthy of clinical application.

Objective To evaluate the early clinical outcome of one‐stage posterior approach operation for rigid scoliosis caused by lumbosacral hemivertebra in adolescencts .Methods Eighteen adolescencts with rigid scoliosis caused by lumbosacral hemivertebra were surgically treated by the posterior hemivertebral resection and long segment fixation .Hemivertebrae were sited in L5 (14 cases) ,S1 (4 cases) .There were 12 cases of full‐segmented hemivertebrae and 5 cases of semi‐segmented hemivertebrae and 1 case of wedge vertebral body ,10 patients had coronal trunk imbalance .Results The patients were successfully completed sur‐gery .The operation time was 4 .5-8 .5 h ,averaged 6 .3 h ;and the perioperative bleeding was 600-2 800 mL ,averaged 1 180 mL . 2 patient suffered from nerve root injury who received neuro nutrition drugs and Prednisolone after operation and recovered com ‐pletely after one weeks .All cases were follow ed up for 12-38 months ,averaged 21 .6 months .The coronal Cobb angles of lumbo‐sacral curve and proximal lumbar after one week of operations and at the time of the last follow‐up were much better than those be‐fore the operations ,the differences were statistically significant (P<0 .05) .Postoperative radiography demonstrated that no implant failure was observed .Coronal trunk shift was improved in 17 patients after surgery ,1 patient had coronal trunk decompensation . Conclusion The posterior surgery with hemivertebrae resection and long segment fixation is an effective procedure in the treatment of rigid scoliosis caused by lumbosacral hemivertebra in adolescencts .The reconstruction of the coronal plane is the key to the oper‐ation .

Objective: To revise the Griffith Mental Development Scales and establish the norm being suited to the Chinese local conditions. Methods: The standardized sample consisted of 2022 children aged 0 to 7 years old was collected in a stratified and random way according to city rank, age, sex, paternal occupations. Each subject was tested individually and filled in a form. Results: The total sample had better representation. The mean of GQ was about 100, and the distribution of GQ is normal. Item analysis indicated that the item difficulty was about 0.5 and discrimination was from 0.62 to 0.78. A few orders of items were revised. The scorer reliability was 0.953. The test-retest reliability was 0.948. The correlation coefficients were 0.481 to 0.854 among the sub-scales or between sub-scales and General DQ. The result of exploratory factor analysis had three factors. The ratio of variance was 79.8%.Conclusion:Griffith Mental Development Scales have ideal reliability and validity.

The examinations of blood and bone marrow in 125 patients with visceral leishmaniasis revealed that seven routine parameters of the blood samples were below the lower limit of normal in most cases and 64.8% of the cases showed complications with iron deficiency anemia(IDA) and cell maturation disorders.Therefore, iron deficiency anemia and significant reduction of blood components can be used as indicators on the severity of Leishmania infection.

AIM:To investigate the effect of intercostals neural blockade(INB)combining with intravenous dexamethasone on postoperative pain,nausea and vomiting and rehabilitation after laparoscopic cholecystectomy(LC).METHODS:Seventy-two patients with ASA I-Ⅱ undergoing LC were randomly divided into three groups with twenty-four patients in each group.Group DI received intravenous dexamethasone infusion before induction combining with INB.Group I only received INB.Group C was control group.Propofol and remifentanil consumption were recorded,postoperative pain and fatigue were assessed according to a pain and fatigue severity score using a subjective analog visual scale(VAS)1,4,12,and 24 h after the surgery.The incidence of postoperative nausea and vomiting,times to first enterocinesia,flatus and hospital discharge were recorded.RESULTS:Propofol and remifentanil consumption,postoperative pain and fatigue scores 4,12,24 h after surgery,the postoperative nausea and vomiting incidences,times to first enterocinesia and flatus,times to hospital discharge were significantly lower in Group DI and I than those in Group C(P