Objective: To study the DNA ploidy and DNA index (DI) in human benign and malignant bronchopulmonary change, and evaluate their value in diagnosis of benign and malignant bronchopulmonary diseases.Methods: The DNA ploidy and DI were analysed by image cytometry analysis (ICM) in 39 cases of bronchitis, 45 cases of squamous metaplasia, 45 cases of dysplasia,and 63 cases of carcinoma.Results: The mean DI for bronchitis and squamous metaplasia were 0.92 and 1.03 respectively, and dysplasia was 1.34,while the mean value for carcinoma was 1.72.Among the four groups,the difference was of evident statistical significance.Conclusion: The DNA content and DNA aneuploidy are with different percentage in benign and malignant bronchopulmonary pathological change.Quantitative analysis of the DNA ploidy and DI may be beneficial in diagnosis and differencial diagnosis of benign and malignant changes,which can provide objective data for clinical treatment and prognosis.

Objective Comparing the difference in postoperative recurrence,complications,quality of life and cosmetic results between patients receiving radical mnastectomy and breast conserving surgery,provides an evidence of breast conserving surgery superior to radical mastectomy.Methods A retrospective analysis of 477 breast cancer patients cases in Department of General Surgery,Third People's Hospital of Baoji City from January 2009 to January 2012.These patients were divided into two groups:the control group 229 cases (48％) underwent conservative surgery treatment and the observation group 248 patients (52％) underwent radical surgery.Using SPSS15.0 statistical software analysis and compare with recurrence,postoperative complications,breast cosmetic effect and quality of life for these two groups of patients.Results In breast-conserving group compared with radical mastectomy group,the one and two year recurrence or metastasis rate were not statistically different between the two groups (P ＞ 0.05),the incidence of postoperative complications was significantly decreased (P ＜ 0.05).The scores for quality of life between the breast-conserving group and radical mastectomy group were all significantly different (P ＜ 0.05).Excellent cosmetic results in breast-conserving group was 78.52％,which was significantly higher than that in the radical mastectomy group (61.34％),the difference was statistically significant (x2 =5.86,P ＜ 0.05),The two groups are not significant in overall survival time (x2 =3.154,P ＞ 0.05) and progression free survival (x2 =4.243,P ＞ 0.05) as two indicator of long-term efficacy.Conclusions Conservative surgery compared with radical mastectomyhave less clinical complications,more breast cosmetic effect,better survival quality,and both of them share the same recurrence or metastasis and survival rate,so conservative surgery should be preferable in the clinical application.