Objective To explore the clinical diagnosis and surgical treatment of inflammatory pseudotumor of the lung. Methods From January 2002 to December 2008,the clinical data of 50 cases with pulmonary inflammatory pseudotumor were retospectively analyzed. Result 18 cases of preoperative diagnosis, the four cases of lobectomy, pulmonary wedge resection in 13 cases, and the rest are mass surgery, intraoperative tumor mostly see substantive, tumor visceral pleural surface without sag and shrinkage, tumor palpation There are hard and soft white felt, with incomplete tumor capsule, easily stripped. Resection of the pathological specimens were confirmed to be inflammatory pseudotumor, no operative complications and death in patients with follow-up 1～8 years, both curvived, without recurrence. Conclusion Inflammatory pseudotumor of their clinical performance and imaging characteristics of the lack of change in the low rate of preoperative diagnosis, surgical treatment of the main diagnostic, intraoperative frozen biopsy to determine pathology surgery, surgical approach to the limitations of pneumonectomy or lobectomy excision.

The ghrompspine fr.agile .sites and micronucleus expression of peripheral lymphocytes were studied in 23 cases with lung cancer 23 cases with uterus cancer 13 cases with ovary cancer and 20 control subjects, using TC199 medium containing 5% bovine serum. The results showed that the chromosome aberration and micronucleus rates of the three group patients were significantly higher than that of the control group, but differences between the three group patients were not statistically significant

Graft versus host disease is the most common complication of allogeneic hematopoietic stem cell transplantation.It includes two different types,i.e.acute and chronic types.Acute graft versus host disease (aGVHD) is the immune response of T cells from the donor to unmatched major histocompatibility complex (MHC) from the host.It has unique pathogenesis and pathological changes and complex clinical manifestations with multiple organs involved.This paper reviewed the progress from home and abroad in diagnosis and treatment of acute graft versus host disease.

The changes of plasma Fn content in rabbits of hemorrhagic and endotoxic shock has been assayed by means of single and double immunodiffusion tests. The results showed that Fn level significantly declined at 30 minutes after hemorrhagic shock and remained at low level with development of shock. But in the rabbitns transfused at 30 minutes after shock Fn level turned to normal as blood pressure increased. Fn content was significantly elevated at 30 minutes and significantly decreased at 60 minutes after endotoxic shock. The possible pathophysiologic and clinical significance of these changes was disscussed.

The pathogenesis and clinical manifestation of histiocytosis are veriant, and misdiagnosis is relatively high. We reviewed a total of cases of this disease and related literature, and the possibility pathogenesis and its clinical features. were discussed.

Objective: To make an English Learning Anxiety Scale (ELAS) based on the Foreign Language Classroom Anxiety Scale (FLCAS) and to do a psychometric test of the ELAS. Method: After translation of the FLCAS into Chinese and did item adaptation to form an ELAS. It was administered to 669 college students with major field other than English. Result: The ELAS was composed of 23 items in four subscales: nervousness , worry, apprehension of being questioned, and sense of anxiety.Factor loadings in the exploratory factor analysis were: A1, 0.46-0.70; A2, 0.53-0.73; A3, 0.55-0.70, A4,0.50-0.67. 48.95% of the total variance could explained. The Cronnbach?is 0.70-0.89, split-half reliability(S-B), 0.71-0.88. ?2/df, RMSEA, GFI, AGFI, NFI, NNFI, CFI, IFI of the goodness of fit indices of confirmatory factor analysis were 2.40, 0.05, 0.92, 0.90, 0.85, 0.89, 0.90, 0.90. The correlation coefficient between ELAS and CET4 score is-0.25~0.64. The correlation coefficient between ELAS and the subscales was 0.69~0.80. The correlation coefficient between the subscales was 0.45~0.63. Conclusion: ELAS has good reliability and validity, could be an effective research instrument in studying anxiety of Chinese college students with major field other than English.

Objective To prepare calcium alginate-chitosan intragastric floating beads and investigate the influences of various factors on the floating characteristics of beads.Methods Sodium alginate solution added with frother was slowly dripped into chitosan-calcium chloride solution added with acetic acid,calcium alginate-ehitosan intragastric floating beads were obtained after drying.The effects of frother,addition amount of acetic acid,the concentration of alginate solution,chitosan and calcium chloride solution on the floating characteristics of beads were investigated.Results Frother and addition amount of acetic acid were the main influence factors on the floating characteristics,and the concentrations of alginate solution, chitosan and calcium chloride solution also had some influences.Conclusion The calcium alginate-chitosan intragastrie floating beads with favorable floatability could be achieved through adjusting the formula,it laid a foundation for the furether development of the preparations in intragastric floating preparations.

Objective To assess the violence risk levels of the community patients with severe mental illness and Analyze the associated factors.Methods A working group composed of psychiatrists,community police,FIMITIC staff,community physicians,neighborhood or village committee members was established.501 community patients with severe mental illness were evaluated with Violence Risk Assessment Scale by working group.While the data of the general demograpbic,medical history and violence history was investigated.Logistic regression analysis was used to explore the factors associated with violence.Results In 501 patients,risk levels of grade 0:124cases (24.8％),grade 1:165 cases (32.9％),grade 2:118 cases (23.5％),grade 3:59 cases (11.8％),grade 4:28 cases (5.6％) and grade 5:7 cases (1.4％).Logistic regression analysis showed four significant risk factors,which were schizophrenia (OR 4.139),no taking medicine (OR 6.883),unstable condition (OR 234.534) the number of previous violence(OR 3.457) (P ＜ 0.05).Logistic regression equation:Logit (severe violence) =-8.511 + 1.420 (schizophrenia) + 1.929 (no taking medicine) + 5.458 (unstable condition) +1.241 (the number of previous violence).Conclusion The results of violence risk assessment and risk factors have directive significance for management of community patients with severe mental illness.

AIM: To study the apoptotic effect of TNFα on rat pulmonary microvascular endothelial cells (PMVEC) and the influences of Fas, NF-κB in its mechanism. METHODS: Apoptosis of PMVEC was analyzed and quantitated with TUNEL, flow cytometer. The distribution of NF-κB was detected via histoimmunochemical staining in TNF-treated cells and the control. Northern blot was applied to assess the influence of TNF on PMVEC Fas expression. Fas antibody was used to investigate the apoptotic effect of Fas on PMVEC. Activation of caspase-8 was detected with Western blot. Expression of caspase-3 was analyzed with histoimmunochemical staining. RESULTS: After treatment with 5×108 U/L TNF for 24 hours, viable PMVEC significantly diminished. Apoptosis rate was 14.0%±3.1% detected with TUNEL, and 13.1% with flow cytometer. Histoimmunochemical staining showed that NF-κB relocated from cytoplasm to the nuclear. When the cells were co-cultured with TNF and APDC, an NF-κB inhibitor, less cells were viable and more cells were positively stained with TUNEL. Fas expression in PMVEC was elevated treated with TNF. Apoptosis in PMVEC was found aggravated, when the cells were co-cultured with TNF and anti-Fas antibody. The positive rate was 24.1%±1.5% with TUNEL. Increase of caspase-8 activation was manifested by Western blot following TNF stimulation. Caspase-3 expression was found elevated using histoimmunochemical staining. Cell permeable caspase-3 inhibitor significantly ameliorated PMVEC apoptosis induced by TNF. CONCLUSION: 1. Large dose of TNF(5×108 U/L) can induce apoptosis in rat PMVEC. 2. NF-κB has a protective effect on PMVEC apoptosis. 3. TNF up-regulates Fas expression in PMVEC. And the latter takes a part in apoptosis. 4. TNF induced caspase-8 activation in PMVEC, and more caspase-3 was expressed. These may be involved in PMVEC apoptosis induced by TNF.

Angiopoietin-1 (Ang-1) is a newly-found endothelium-specific proangiogenic factor and it had been proved essential roles in both vasculogenesis and angiogensis. Among them, its anti-leakage ability may have great potential applications in clinical treatment of vascular hyper-permeability in a variety of diseases such as cancer, diabetic retinopathy, rheumatoid arthritis, asthma. In this review, some research progresses focused on this aspect are discussed. [