The growth and metastasis of tumor relies on oxygen and nutrients provided by neonatal blood vessel. When no angiogenesis, the tumor growth will be obviously inhibited. At present, anti-tumor angiogenesis strategies are increasingly becoming a focus of attention and study at home and abroad. However,because of the complexity of the antiangiogenesis, the clinical effects of antiangiogenesis alone is not so satisfied, while this is reversed when combined with radiotherapy.

There are many causes of children cerebral infarction, including cerebrovascular malformation,autoimmune cerebrovascular phlogistic, infection, trauma and the high state of blood coagulation. Because the brain development is not mature, the children is the high-risk group of traumatic cerebral infarction. The early diagnosis of traumatic cerebral infarctions relies on the dynamic performance of the clinical observation, taking head CT or MRI quickly, especially diffusion-weighted imaging, which is more sensitive on the judgement of acute cerebral infarction period. Common sites of traumatic cerebral infarction are basal ganglia. The infarcts are usually small. Treatment on traumatic cerebral infarction must give priority to non-operation. Early diagnosis and prompt treatment can provide better prognosis than adults.

Objective To understand the status of the disease in local population and the fluoride content in drinking water in the endemic areas of endemic fluorosis in Etuoke Banner of Inner Mongolia,and to provide a scientific basis for making strategies in prevention and control of the disease.Methods Totally 100 endemic fluorosis villages were selected as survey sites,to study the progress and effect of water-improving and defluoridation projects in Etuoke Banner in 2015.In monitoring villages with improved water,1 water sample from the tap water was collected to determine the fluoride level,and in water unimproved villages,1 water sample from each direction of the east,south,west,north and middle of the villages was collected,respectively,to determine fluoride level.Dental fluorosis of children aged 8 to 12 was examined in each village.Water fluoride was tested according to the Standard Testing Methods for Drinking Water (GB/T 5750.5-2006).Diagnosis of dental fluorosis was based on the Diagnostic Criteria for Dental Fluorosis (WS/T 208-2011).Results A total of 100 diseased villages were investigate,the water-improving rate was 39.00％ (39/100).Among the 39 water-improving projects,normal operating rate was 66.67％ (26/39),intermittent operating rate was 15.38％ (6/39) and scrapped projects accounted for 17.95％ (7/39);the qualified rate of water fluoride projects was 53.85％ (21/39).A total of 268 tap water samples were collected,the mean of water fluoride was 1.39 mg/L,and the range was 0.22-5.57 mg/L.In the 61 waterunimproved villages,the water fluoride level ＞ 1.2 mg/L in the drinking water accounted for 49.18％ (30/61),covering a population of 5 231 people.The water fluoride level ＞ 2.0-4.0 mg/L in the drinking water accounted for 18.03％ (11/61),covering a population of 2 326 people;the number of village with water fluoride level ＞ 4.0 mg/L was 1,accounted for 1.64％ (1/61),covering a population of 162 people.A total of 1 040 children aged 8 to 12 in the survey villages were examined,the total rate of dental fluorosis was 9.71％ (101/1 040),the index of dental fluorosis was 0.18,and the prevalence was negative.Conclusion The water-improving and defluoridation projects in Etuoke Banner,Inner Mongolia has a certain effect on children's dental fluorosis,but water fluoride content has exceeded the standard significantly,the water improvement measures should be further strengthened.

Objective To discuss the influence of atorvastatin and rosuvastatin on carotid intima-media thickness(CIMT) of patients after percutaneous coronary intervention (PCI).Methods 142 patients after PCI with CIMT increasing were randomly divided into Lipitor group (n=71) and Crest group (n=71).The Lipitor group was given atorvastatin(20mg) orally once a day.The Crest group was given rosuvastatin(20mg) orally once a day.The changes of low density lipoprotein,high density lipoprotein,liver function and CIMT before and after 12 weeks treat-ment were observed in two groups.Results After treatment for 6 months, the levels of LDL-C, CIMT in Lipitor group were lower than before treatment with statistical difference[(3.37 ±1.20)mmol/L vs (2.0 ±0.29)mmol/L, (1.29 ±0.06)mm vs (0.91 ±0.23)mm](t=4.032,3.523,all P<0.05);the levels of LDL-C,CIMT in Crest group were lower than before treatment with statistical difference[(3.38 ±1.21)mmol/L vs (1.8 ±0.15)mmol/L, (1.30 ±0.16)mm vs (0.81 ±0.15)mm](t=4.700,3.892,all P<0.05).The decreasing degree of LDL-C, CIMT was significantly lower in Crest group than that in Lipitor group with statistical difference( t=3.668,3.002,all P<0.05 ) .The level of HDL -C in Lipitor group was higher than before treatment with statistical difference [(1.01 ±0.36)mmol/L vs (1.10 ±0.31)mmol/L](t=3.801,P<0.05).The level of HDL-C in Crest group was higher than before treatment with statistical difference[(1.03 ±0.32)mmol/L vs (1.15 ±0.35)mmol/L](t =3.722,P<0.05).The decrease degree of HDL-C was significantly higher in Crest group than that in Lipitor group with statistical difference(t=3.568,P<0.05).Conclusion Rosuvastatin has better effect than atorvastatin on the reversal of atherosclerosis process.

In the recent years, with the improvement of conditioning regimens, the prevalence of high-resolution HLA matching, as well as the application of high-intensity broad-spectrum antibiotics, unrelated donor transplantation for the treatment of severe aplastic anemia has been improved significantly, with lower incidences of graft failure, graft-versus-host disease, infectious complications, etc. Studies have already confirmed that transplantation from an unrelated donor should be recommended as an effective therapy for children and young adults who do not respond to the first course of immunosuppressive therapy.

Objective To investigate the risk factors of pneumonia associated to elderly patients with cerebral stroke.Methods Totally 248 elderly patients with stroke were retrospectively analyzed on medical history,treatment and prognosis.Results In 248 cases of senile stroke patients,78 cases had an associated pneumonia,accounting for 31.5％.The onset with admission period ≥48 h was in majority (48 cases),less than 48 h in 30 cases (38.5％).12 patients (15.4％)were involved blood culture,38 cases sputum culture,accounting for 48.7％.In the univariate correlation analysis,older age,consciousness,basic diseases,stroke location,NIHSS score of nasal feeding therapy were associated with associated pneumonia (all P＜0.05).As compared to patients without no associated pneumonia,the patients with associated pneumonia had more aged and higher proportions of bulbar paralysis and impaired consciousness,more underlying diseases.At the time of admission,increased occurrences of National Institute of Health Stroke Scale (NIHSS) score,brainstem stroke and multiple feeding treatment appeared in most of patients.Multivariate Logtistic regression analysis showed that age≥ 65 years,history of pulmonary disease,bulbar paralysis,disturbance of consciousness,nasal treatment among older stroke were the associated pneumonia risk factors.The hospitalized time was prolonged [(31.3±20.4)d and(17.6±8.1)d,t＝7.57,P＝0.001] and fatality rate increased (41.0％ vs.4.1％) in patients with pneumonia than without pneumonia(x2＝ 54.96,P＝ 0.000).The independent factors of death were aged ≥ 75 years(OR＝1.6,95％CI:1.0-2.6),NIHSS＞13 (OR＝5.0,95％CI:1.7-24.6) and pulmonary infection(OR＝5.2,95％ CI:1.8-17.3).Conclusions The occurrence of associated pneumonia in elderly patients with cerebral stroke is related with age,underlying disease,state of consciousness and NIHSS scores.The prevention and treatment of relevant factors can improve prognosis.

Objective To observe the clinical efficacy of point injection of spleen polypeptides in the treat-ment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Totally 60 patients with AECOPD were randomly divided into the observation group and the control group,30 cases in each group.Based on conventional treatment,the observation group was treated by point injection of spleen polypeptides,4ml for each time, 1 time a day;and the control group was given equivalent volume of spleen polypeptides by intramuscular injection.The treatment lasted two weeks.The clinical efficacy,PCT,inflammatory and ADRs of patients in the two groups were observed.Results In 7 days of treatment,the clinical efficacy was 87% in the observation group,which was better than 60% of the control group (χ2 =5.45,P=0.019).PCT,interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF -α)of the observation group and the control group were (1.84 ±1.48)ng/mL and (2.21 ±1.75)ng/mL,(32.54 ±6.62)ng/L and (38.94 ±5.69)ng/L,(31.51 ±6.03)ng/L and (36.75 ± 7.95)ng/L,(45.90 ±4.40)ng/L and (51.53 ±2.21)ng/L respectively,which were lower than before treatment (t=12.76 and 15.25,13.23 and -8.42,-10.43 and 5.78,25.04 and 26.95,all P<0.01),which of the obser-vation group were lower than the control group(t=-2.84,4.01,-2.74,-6.27,all P<0.01).After treatment, PCT,IL-6,IL-8,TNF-αof the observation group and the control group were (1.05 ±0.74)ng/mL and (1.38 ± 0.87)ng/mL,(26.89 ±3.57)ng/L and (32.44 ±5.96)ng/L,(21.40 ±3.41)ng/L and (27.71 ±5.50)ng/L, (32.29 ±2.40)ng/L and (39.77 ±2.57)ng/L respectively,which were lower than before treatment(t=22.40 and 22.44,23.10 and -11.96,21.40 and 12.66,48.94 and 38.81,all P<0.01),which of the observation group were lower than the control group(t=-4.09,-4.26,-5.29,-11.68,all P<0.01).No obvious side effect was found in the two groups in the treatment and followed-up period.Conclusion Point injection of spleen polypeptides can effectively reduce the inflammatory response in patients with AECOPD,improve clinical outcomes,shorten course of treatment,has better clinical value.

The frequencies of sister chromatid exchange (SCE) and micronucleus (MN) of peripheral blood lymphocytes were determined in 15 patients with RB, their 24 parents and 16 normal controls.The results showed that the spontaneous,MMC induced SCE and MN rates in patients were significantly higher than those in controls. Therefore, the results provided some positive evidence for chromosome instability in RB patients. The relationship between chromosome instability and the origin of RB was also discussed

Objective:To induce neural stem cells(NSCs)differentiating into oligodendrocytes in vitro and provide experiment foundation for NSCs-derived oligodendrocytes.Methods:The primary NSCs were isolated from endbrain and midbrain of neonatal rats,and then the cells were cultured in vitro.NSCs were induced by thyroid hormone(T3)and(or)insulin,and the effect of T3 and insulin was analysed by comparing the proliferation and the differentiation rate of NSCs and by measuring the prominency of GalC-positive cells.Results:NSCs were induced into oligodendrocytes by thyroid hormone and/or insulin,and different concentration of T3 and/or insulin had different effects on differentiation.Conclusion:Thyroid hormone and insulin can induce NSCs to differentiate mainly into oligodendrocyte and promote the proliferation and maturation of oligodendrocytes.The effect is more outstanding when 40ng/ml T3 is used in combination with 25?g/ml insulin.

Objective: To observe the clinical effects of combination of propofol,fentanyl and in surgical abortion. Methods: A total of 184 early-pregnant women were randomly divided into two groups.The women in group Ⅰ received propofol 2.5 mg/kg intravenously(n=92),the women in group Ⅱ received the combination of propofol,fentanyl and atropine intravenously(fentanyl 1 ?g/kg,atropine 0.5 mg,propofol 1 mg/kg)(n=92).To compare the efficacy of those two kinds of anesthesia,many measurements were taken, which included the total dose of propofol applied,induction time,recovery time,self-walking time,operative time,blood loss during the abortion,dilatation of the uterine cervix,blood pressure,heart rate,breathe,pain caused by injection and post-operation uterine contraction. Results: Many differences were found in the group who received the combination of propofol with fentanyl and atropine,when compared to those measurements in the group received propofol only.Significantly less(amount) of propofol was needed.The induction time was significantly shorter.The slowing of heart rate,dropping of blood pressure and reduction of breathing were significantly less.The dilation of the uterine cervix was more complete and took much less time.The pain caused by injection and post-operation contraction was significantly less frequent and less severe. Conclusion: Applying the combination of propofol,fentanyl and atropine has several clinical benefits which include less propofol need,less inhibition to the respiration and cardiovascular system,and less pain caused by injection and post-operation contraction.