1.Progress on children traumatic cerebral infarction
International Journal of Pediatrics 2011;38(1):65-67
There are many causes of children cerebral infarction, including cerebrovascular malformation,autoimmune cerebrovascular phlogistic, infection, trauma and the high state of blood coagulation. Because the brain development is not mature, the children is the high-risk group of traumatic cerebral infarction. The early diagnosis of traumatic cerebral infarctions relies on the dynamic performance of the clinical observation, taking head CT or MRI quickly, especially diffusion-weighted imaging, which is more sensitive on the judgement of acute cerebral infarction period. Common sites of traumatic cerebral infarction are basal ganglia. The infarcts are usually small. Treatment on traumatic cerebral infarction must give priority to non-operation. Early diagnosis and prompt treatment can provide better prognosis than adults.
2.Analysis of risk factors for pneumonia associated to elderly patients with cerebral stroke
Chinese Journal of Geriatrics 2012;(12):1063-1065
Objective To investigate the risk factors of pneumonia associated to elderly patients with cerebral stroke.Methods Totally 248 elderly patients with stroke were retrospectively analyzed on medical history,treatment and prognosis.Results In 248 cases of senile stroke patients,78 cases had an associated pneumonia,accounting for 31.5%.The onset with admission period ≥48 h was in majority (48 cases),less than 48 h in 30 cases (38.5%).12 patients (15.4%)were involved blood culture,38 cases sputum culture,accounting for 48.7%.In the univariate correlation analysis,older age,consciousness,basic diseases,stroke location,NIHSS score of nasal feeding therapy were associated with associated pneumonia (all P<0.05).As compared to patients without no associated pneumonia,the patients with associated pneumonia had more aged and higher proportions of bulbar paralysis and impaired consciousness,more underlying diseases.At the time of admission,increased occurrences of National Institute of Health Stroke Scale (NIHSS) score,brainstem stroke and multiple feeding treatment appeared in most of patients.Multivariate Logtistic regression analysis showed that age≥ 65 years,history of pulmonary disease,bulbar paralysis,disturbance of consciousness,nasal treatment among older stroke were the associated pneumonia risk factors.The hospitalized time was prolonged [(31.3±20.4)d and(17.6±8.1)d,t=7.57,P=0.001] and fatality rate increased (41.0% vs.4.1%) in patients with pneumonia than without pneumonia(x2= 54.96,P= 0.000).The independent factors of death were aged ≥ 75 years(OR=1.6,95%CI:1.0-2.6),NIHSS>13 (OR=5.0,95%CI:1.7-24.6) and pulmonary infection(OR=5.2,95% CI:1.8-17.3).Conclusions The occurrence of associated pneumonia in elderly patients with cerebral stroke is related with age,underlying disease,state of consciousness and NIHSS scores.The prevention and treatment of relevant factors can improve prognosis.
3.Roles of anti-angiogenic therapy combined with radiotherapy in the treatment of malignant tumors
Cancer Research and Clinic 2011;23(6):430-432
The growth and metastasis of tumor relies on oxygen and nutrients provided by neonatal blood vessel. When no angiogenesis, the tumor growth will be obviously inhibited. At present, anti-tumor angiogenesis strategies are increasingly becoming a focus of attention and study at home and abroad. However,because of the complexity of the antiangiogenesis, the clinical effects of antiangiogenesis alone is not so satisfied, while this is reversed when combined with radiotherapy.
4.Unrelated donor hematopoietic stem cell transplantation for the treatment of severe aplastic anemia
Journal of Leukemia & Lymphoma 2010;19(5):316-319
In the recent years, with the improvement of conditioning regimens, the prevalence of high-resolution HLA matching, as well as the application of high-intensity broad-spectrum antibiotics, unrelated donor transplantation for the treatment of severe aplastic anemia has been improved significantly, with lower incidences of graft failure, graft-versus-host disease, infectious complications, etc. Studies have already confirmed that transplantation from an unrelated donor should be recommended as an effective therapy for children and young adults who do not respond to the first course of immunosuppressive therapy.
5.THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS
Journal of Chongqing Medical University 1986;0(04):-
The frequencies of sister chromatid exchange (SCE) and micronucleus (MN) of peripheral blood lymphocytes were determined in 15 patients with RB, their 24 parents and 16 normal controls.The results showed that the spontaneous,MMC induced SCE and MN rates in patients were significantly higher than those in controls. Therefore, the results provided some positive evidence for chromosome instability in RB patients. The relationship between chromosome instability and the origin of RB was also discussed
6.PRELIMINARY STUDY ON THE PREPARATION OF ?-BT-HRP CONJUGATES BY PERIODATE AND GLUTARALDEHYDE METHODS
Academic Journal of Second Military Medical University 1982;0(02):-
This paper reports the methods of preparation of ?-BT-HRP conjugates. In the conditions of our laboratory we got this conjugate using the periodate method. Nevertheless, the conjugates were not able to be synthesized by the classical one-step and two-step glutaraldehyde methods. On the basis of these findings, we conclude that for the preparation of ?-BT-HRP the periodate method is very simple and effective
7.The Effect of ProstaglandinF_(2a) (PGF_(2a)) in the Blood Plasma and Interleukin-1?(IL-1?) in the Blood Serum of Endometriosis in the Rats Treated with Complex Prescription Dragon’s Blood Plaster
Journal of Zhejiang Chinese Medical University 2006;0(03):-
[Objective] To optimize the exact preparative technique of complex prescription Dragon’s Blood Plaster(DBP),to evaluate the therapeutic effect to endometriosis rats with acupoint therapy and to discuss its probable mechanism.[Methods] Making into DBP through the preparation of ultra-fine powder,extraction of the volatile oils and their ointments were made as well.Induced by surgery for the experimental endometriosis ,observed that the levels of PGF2a in the blood plasma and IL-1? in the blood serum in different control groups.[Results] Complex prescription DBP could inhibit the ectopic endometrium hyperplasic ,and decrease the levels of PGF2a.No significant difference in IL-1? in the blood serum.[Conclusion]The treatment by acupoint therapy with complex prescription DBP is effective to endometriosis.It could inhibit the ectopic endometrium hyperplasic and promote the shrinking of glands.
8.Discussion on the Medicine History Teaching Esthetically Educates Discourse how to Pppreciate the Beauty of the Medical Science History Education
Chinese Medical Ethics 1996;0(01):-
the education the education of appreciate the beauty is a kind of character education,.And the character of a kind of spirit level of structure the education.It can educate what medical science living to appreciate beauty the ability,and affect the medical science the concept of value that living,and increase the medical science the human life state that living,and educate the medical science the creation thought that living.this article basic of medical science history teaching to discuss how foster the students to appreciate the beauty of the education.
9.Application of moving reticulation flap to repair skin defect during/after breast cancer operation
Chinese Journal of Postgraduates of Medicine 2006;0(17):-
Objective To explore a safe and simple method to repair the skin defect during/after breast cancer operation. Methods Making the moving reticulation flap on two sides of the defect surface. Results The flap in 19 cases all recovered. Meshes had effect on drainage and reduced the number of drainage tube. The cuts on the reticulation flap, which were 1.0 cm, 1.5 cm and 2.0 cm long, were healing with new tissue after 9, 12 and 16 days. If the mesh was larger, the dilating area of flap would be larger and the healing time would prolong. After the operation, the flap was elastic. Patients′ skin on the chest didn′t feel tight and also chemotherapy would not be affected. Conclusion Moving reticulation flap to repair the defect skin during/after the breast cancer operation is an effective method, which can avoid the grafting skin operation and fits various defect sizes.
10.Apoptosis Expression-based Pattern Recognition System of Four Properties of Chinese Materia Medica——Panax quinque folium vs. Panax ginseng in Drug Property against MPP~+-induced Apoptosis of SH-SY5Y Cells
China Pharmacy 2005;0(18):-
OBJECTIVE:To investigate the effects of water extract of Panax quinque folium(WEAG,of cool property)and Panax ginseng(WERG,of warm property)on MPP+-induced apoptosis of SH-SY5Y cells.METHODS:SH-SY5Y cells were divided into 4 groups:the control group was cultured in complete medium,model group was cultured with 0.5 mmol MPP+;Panax quinque folium group was treated with 0.5 mmol MPP+ plus different concentration of WEAG,and Panax ginseng group was treated with 0.5 mmol MPP+ and different concentration of WERG concomitantly.WEAG and WERG were added for intervention.the morphology of SH-SY5Y cells was observed by Hoechst33258 staining and the apoptotic rate was detected by FCM;the cell survival rate was measured by MTT chromatometry.RESULTS:Compared with model group,WEAG and WERG markedly reversed the apoptotic characteristics of SH-SY5Y cells,markedly up-regulated MTT value and lowered the apoptotic rate,with WERG showing more potent efficacy than WEAG doing.CONCLUSION:Water extracts of both Panax quinque folium(cool)and Panax ginseng(warm)pose protective effects of different degree against MPP+-induced apoptosis of SH-SY5Y cells,with the Chinese materia medica of warm property showing more potent action against apoptosis.Chinese materia medicas of different drug property have different anti-apoptotic action.