MicroRNA,a type of small non-coding RNA specialized in regulation of gene expression,extensively participates in biological cell development,differentiation apoptosis and other cellular processes.Studies have shown that microRNA plays vital regulatory roles in epilepsy.Its mechanisms include regulation of inflammatory responses,proliferation of glial cells,the reconstruction of the synaptic contact and pro-apoptotic gene expression.This article reviews the molecular mechanisms of microRNA in regulation of epilepsy and the possible regulatory roles of microRNA in other nervous diseases.

Objective To assess the relationship between helicobacter pylori infection and the incidence of di- gestive disease associated with NSAIDs.Methods 88 patients who had taken NSAIDs undergoing endoscopy were selected.The patients were assigned into two groups:helicohacter pylori infection group and no-hslicobacter pylori group.Results Digestive disease associated with NSAIDs occurred in 16.67% of patients with helicobacter pylori infection compared with 19.23% in no-helicobacter pylori group.There was no significant difference in statistical analysis.Conclusion Helicobacter pylori infection dosen't aggravate digestive disease associated with NSAIDs.

Acupuncture Therapy ; Adolescent ; Adult ; Aged ; Child ; Facial Paralysis ; therapy ; Female ; Humans ; Male ; Middle Aged ; Young Adult

The examining work of the third class medical metrology station in Xinjiang Military Area Command in 2006 is completely summarized along with the introduction of examining measures and experiences.Aiming at the problems in the examination,the importance of leader's recognition,propaganda and elaborate organization are emphasized.According to problems in the station's building,concrete methods for establishing corresponding mechanisms in coordination,learning,supervision and inspiring in medical metrology are discussed.

Objective: To analyze the application status of the EQ-5D and SF-6D in cost-utility analysis ( CUA) . Methods: The data from PubMed data base from 2003-2012 was conducted as the main resource in econometric analysis. Results: There is no certain increasing trend of literature quantity in the recent 10 years’ application of EQ-5D and SF-6D in the CUA. The main published language was English and the main country was the United Kingdom. The core authors of researches on the CUA estimated by EQ-5D and SF-6D had not been formed, however, the core periodicals had been formed. The literatures involve wide-spread diseases, mainly known as Motion system and pain diseases. Most of the effectiveness could be calculated with quality adjusted life year ( QALY) , the object of CUA is mainly on the medicine, operation and health intervention. Conclusion: Appicating EQ-5D and SF-6D in CUA and research content of the literatures has wide distribution width, although it has shown centralized trend, which still needs more studies by related researchers.

Objective: Digital images processing is widely applied in the fields of biology and medicine, and some achievements have been gained by this technique. But there is few reports on measure the parameters of morphology of pathology from the patients which were threated by ovulation induction, by computer processing techniques. The work shows it has significant value in clinical diagnosis and reproductive medicine at present and in the future. Methods: Write the programmeces by Image Processing Toolbox in MATLAB. The original pathology images are preprocessed by 4 steps: step 1: read imagejstep 2: imopen the curve background brightness; step 3: adjust the background; step 4: adjust the contrast. Then segmentation image by 4 steps; step 1: read image; step 2: estimation the image; step 3: remove the noise; step 4: find the boundaries. The end, measure the parameters of morphology. Results: The pathology was studied percase for their area, perimeter, maximum diameter, equivalent diameter and metric. Conclusions: Image Processing Toolbox is useful to measure the parameters of morphology of pathology.

In recent years,research on carotid atherosclerosis has turned to the aspect of neovascularization in vulnerable plaques.The evaluation of neovascularization in plaques using contrast-enhanced ultrasonography has become one of the novel technologies to determine the plaque stability.This article reviews the principles of contrast-enhanced ultrasonography and its application in the evaluation of neovascularization in carotid atherosclerotic plaques and vulnerable plaques.

Objective To investigate the effect of strengthening self -management on the treatment compliance and outcome in hepatitis B patients with decompensated cirrhosis treated with entecavir.Methods A total of 120 hepatitis B patients with decompensated cirrhosis, who received antiviral therapy with entecavir in our hospital from January 2010 to January 2012,were randomly divided into control group (n=60)and intervention group (n =60).Both groups received routine nursing care;in addition,regular telephone follow -up was performed for the intervention group to provide guidance for the self -management during the comprehensive prevention and treatment of decompensated cirrhosis.The two groups were compared in terms of withdrawal rate,rehospitalization rate,hepatitis B virus (HBV)DNA negative conver-sion rate,incidence of primary liver cancer,and mortality one year later.Continuous data were analyzed by t test,and categorical data by chi -square test or Fisher′s exact test.Results The withdrawal rate and rehospitalization rate in the intervention group were 0 and 18.3%, respectively,versus 8.3% and 35% in the control group (P <0.05 for both).The HBV DNA negative conversion rate,incidence of prima-ry liver cancer,and mortality in the intervention group were 90%,3.3%,and 5.3%,versus 88.3%,5%,and 6.7% in the control group (P >0.05 for all).Conclusion Strengthening self -management,as well as regular health education,can improve treatment compliance and promote recovery in hepatitis B patients with decompensated cirrhosis treated with entecavir.

Objective To study the effects and significance of thrombexane -B_2(TXB_2)and six-ketone-prostaglandin(6-k-PG)F1 α levels in the primary type of hyper-acute cerebral infarction with different sensitivities to aspirin.Methods Sixty-three patients with primary type of hyper-acute cerebral infarction were divided into three groups based on their sensitivities to aspirin:aspirin resistance(AR)group,aspirin semiresistance(ASR)group,aspirin sensitivity(AS)group.TXB_2 and 6-k-PGF1α levels were measured,compared and analyzed in the three groups before and two weeks after taking aspirin(100 mg/d).Results The total effective rate in AS group[87.0%(20/23)]was significantly higher than that in ASR group[55.0%(11/20)]and AR group[30.0%(6/20)](P<0.05).There was no significant difference of TXB_2 and 6-k-PGF1 α among the three groups before taking aspirin.After taking aspirin for two weeks,TXB_2 leveh in all the three groups were lower than those before making aspirin(P<0.01),6-k-PGF1α levels in all the three groups were higher than those before taking aspirin(P<0.01).Conclusions Aspirin can decrease the TXB_2 concentration and increase the 6-k-PGF1α concentration of the primary hyper-acute cerebral infarction. It may be reduce the risks of re-infarction after the primary acute infarction. Monitoring the concentration of TXB_2 and 6-k-PGF1α can be helpful to evaluate rehabilitation prognosis.

Objective To investigate the effect of vagina reconstruction using tissue-engineering biological material (acellular dermal matrix) in an animal model.Methods Vagina excision and vagina reconstruction with tissue-engineering biological material were performed in 12 Chinese experimental miniature pigs.The control group was matched with two of normal vagina specimens resected.At week 1,2,4,6,8,12 after surgery,the animals were sacrificed,respectively,and the neovaginas were prepared for immunohistochemical and Van Gieson (VG) staining to evaluate the status of various layer growth of vagina.Epithelial broad spectrum of monoclonal antibodies of AE1/AE3 and α-actin were used to test the existence of epithelial and smooth muscle tissue by immunohistochemical staining.The ultrastructure of neovagina was studied by transmission electron microscope at week 1 and 12 after surgery.Contractile function of isolated smooth muscle of neovagina was evaluated by chemical and electronic stimulation after 12 weeks' reconstruction.Results (1) Epithelization of 2/3 neovaginal mucosa was observed within 1 week.Only 1-2 layer epitheliums were observed under the light microscopy and epithelial cells with characteristics of loose and disarrangement were shown with the electron microscopy.Within 4-6 weeks,epithelization in mucosa of neovaginal canal was intensified to 4-5 layers.After 12 weeks,the differences between the neovagina and the native vagina were harldy noted either in the gross or microscopically.(2) After 4 weeks,a few smooth muscle cells were observed with VG and immunohistochemical staining,and homogeneous muscle bundle was formed.(3) After 12 weeks,similar contractile responses between neovagina and native vagina were observed when KCI and electrical stimulation with different frequency and voltage were given [(2.96±0.29)g vs.(3.14±0.30)g,(3.43±0.34)g vs.(4.65±0.73)g,(4.92±0.38)g vs.(4.89±0.44)g].Conclusion The tissue-engineering biological material might be an ideal graft used in the reconstruction of vagina.