Objective To explore risk factors of neurosurgical patients in bed with deep vein thrombosis (DVT) and to compare the Autar Scale with the Caprini Scale for predicting DVT formation. Methods Retrospective analysis of DVT risk factors was conducted on sixty-eight cases neurosurgical patients in bed of three hospitals. In addition, used two kinds of risk assessment scales to assess patient′s level of DVT risk. Results Coma (OR=9.410,95%CI=1.689-52.423), paralysis (OR=4.950,95%CI=1.432-17.105) , infection (OR=2.927,95%CI=1.162-7.373), lower limb central venous catheterization (OR=6.072,95%CI=2.187-16.858) may be risk factors for DVT in neurosurgical patients in bed. The two risk assessment tools were used within 24 hours after admission (χ2=34.861) and within 24 hours after surgery (χ2=52.869) to predict differences in neurosurgical patients with thrombosis risk level, with statistical significance (P < 0.01). Conclusions Nurses should identify risk factors of DVT every day and take preventive measures early to reduce the risks. The Caprini Scale is better than the Autar Scale for predicting DVT formation.

Objective To explore the risk factors of lower extremity deep venous thrombosis (LEDVT) of neurosurgical patients, and to provide references for identifying the most susceptible population and taking preventive measures. Methods A total of 68 cases of neurosurgical patients with LEDVT in three general hospitals from August 2010 to August 2013 were collected. The design method of one to one matching case-control study was used controlling age, sex and neurosurgical disease. Univariate and multivariate analyses were performed to determine the probable risk factors among two groups. Results The univariate analysis showed that coma, paralysis and limb immobilization, infection, trauma and fracture, lower limbs central venous catheterization, trachea cannula or tracheotomy, mechanical ventilation, surgical operation, dehydration and blood transfusion were significantly related to the incidence of LEDVT ( Χ2=4.50-33.23, P<0.05 or 0.01). The Logistic multivariate regression analysis showed that coma (OR=9.410, 95%CI 1.689-52.423), paralysis and limb immobilization (OR=4.950, 95%CI 1.432-17.105), infection (OR=2.927, 95%CI 1.162-7.373) and lower limbs central venous catheterization (OR=6.072, 95%CI 2.187-16.858) were independent risk factors for the development of LEDVT. Conclusions We should pay attention to patients with high risk factors of LEDVT and take preventive measures early to avert the formation of LEDVT.

Objective To evaluate the effect of Angio-Seal vascular closure device by the femoral artery hemostasis.Methods Relative literature was searched by computer,according to the inclusion and the exclusion criteria,which were analyzed by RevMan5.2 software.Results A total of four studies of randomized controlled trial were brought into this research,the total sample size was involved in 3 191 cases,the sample size of the intervention group and the control group respectively was 1 583 and 1 608.The analysis results showed,Angio-seal vascular closure device can significantly shorten the time of hemostasis after femoral artery interventional therapy in patients and the limb braking time.The sensitive analysis results showed that the results stability were high and the conclusions were reliable.Conclusions Application of Angio-seal vascular closure device can significantly shorten the interventional therapy in patients with bleeding time and braking time.

Objective To investigate the effect of Artesunate (Art) on experimental immune myositis (EIM) animal model. Methods Guinea pigs were immunized with rabbit muscle homogenate in Freund′s adjuvant, and a generalized myositis fundamentally similar to human polymyositis was established. These animals were divided into two groups: the control group (injected intraperitoneally with normal saline everyday) and the treatment group (injected intraperitoneally with Art everyday). Results The serum levels of CPK, AST and LDH were significantly lower in the treatment group than those in the control group. EMG demonstrated that the treatment group kept improving along with the elapse of time. Histological findings revealed that the damage of muscle in the treatment group was less severe than that of the control group. Conclusion Art is effective in therapy of EIM guinea pigs. The result of this study provides a reliable evidence that Art might be used for the treatment of PM/DM and other immune diseases.

Objective To explore the ultrasonographic manifestations of the fetal with asplenia syndrome. Methods At 21751 cases of fetal systemic ultrasound examination during 20-40 weeks, 4 cases with asplenia syndrome were diagnosed. and the ultrasonographic manifestations of the 4 cases were analyzed retrospectively. Results The ultrasonographic features of fetal asplenia syndrome;①with complex and serious cardiovascular malformation; ②visceral transposition; ③ absence of spleen. Conclusions When the complex cardiovascular malformations were found by prenatal ultrasound,the position of fetal spleen and internal organs in order to early diagnosis of fetal asplenia syndrome.

Objective To explore the role of CD4+CD25+CD127low/-regulatory T cells (Tregs) in the pathogenesis of psoriasis vulgaris(PV). Methods Flow cytometry analysis was used to detect the amount of Tregs in peripheral blood and ELISA to test the levels of IL-10 and TGF-β1 in blood serum; the suppressive function of Tregs on autologous CD4+CD25-T cells was determined by MTT method. Results No significant difference was found in the proportion of Tregs in PV patients and healthy controls(P>0.05). There was a diminished suppression of Tregs from patients on autologous CD4+CD25- responder T cell proliferation in PV patients when compared with that in controls (P < 0.01). The serum level of IL-10 in patients was lower than that in controls (P < 0.01) while that of TGF-β1 in PV patients was significantly higher than that in controls(P < 0.01). Conclusion Abnormal function of Tregs and low secretion of IL-10 in PV patients might be related to the pathogenesis of psoriasis.

Objective To evaluate the effect of early nursing interventions on the dysphagia of strok e patients.Methods The randomized controlled trials (RCT) on early nursing interventions were collected using the database such as Chinese Science and Technology Periodical Database (VIP),China national knowledge internet (CNKI) and Wanfang Database.The results were analyzed with RevMan5.2 Software.Resuits Six studies were included in the study.The dysphagia recovery rate was significandy increased in the intervention group.Conclusions Early nursing interventions can effectively promote the dysphagia function recovery of stroke patients.

The problems in resources support in Library of Chinese Academy of Medical Sciences were analyzed according to the investigation on the utilization of and demand for information resources in 23 scientific researchers and 37 students in Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences.Certain suggestions were put forward for the solution of these problems in terms of adjustment and optimization of subject resources, in-formation organization and revealing, exchange and communication between users, recommendation and training of subject resources .

Aim To observe the effect of Sinomenine on the activation of NF-?B and the degradation of its inhibitor I-?B in peritoneal macrophages of BALB/c mice in vitro and provide experimental evidence for further evaluation of the antiinflammatory and antirheumatic effects of Sinomenine. Methods Effect of Sinomenine on the activation of NF-?B p65 in the cells was investigated by using fluorescence-labelling and laser confocal scanning microscopy; Effect of Sinomenine on the degradation of I?B-? was investigated by Western blot. Results SIN (0.25,1.25 mmol?L -1) attenuated the activation of NF-?B p65 in peritoneal macrophages of BALB/c mice induced by LPS in vitro. SIN(0.25,1.25 mmol?L -1) inhibited the degradation of I-?B-? in peritoneal macrophages of BALB/c mice induced by LPS in vitro. Conclusion SIN can partially inhibit the activation of NF-?B p65 and the degradation of I?B-? in peritoneal macrophages of BALB/c mice induced by LPS in vitro.

Objective:To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with chronic schizophrenia.Methods:100 cases patients with chronic schizophrenia weree selected.They were divided into rTMS stimulation group and pseudo stimulation group according to the random number table method,and each group include 50 cases.The positive and Negative Syndrome Scale (PANSS) and the Treatment Emergent Symptom scale (TESS) were used to assess the clinical symptoms and side effects before and after the treatment;The Wisconsin Card Sorting Test (WCST) and Repeatable Neuropsychological State Measurement (RBANS) were used to assess the patients' cognitive function before and after treatment.Results:After treatment,the PANSS total score,the positive subscale score,the negative subscale score,the general psychopathological subscale score in the rTMS stimulation group were significantly reducing (P＜0.05),and significantly lower than those in the pseudo stimulation group (P＜0.05),but the TESS scores between the two groups did not differ significantly before and after treatment.The percentage of WCST in rTMS stimulation group was significantly higher than that in the pseudo stimulation group (P＜0.05),and the total time and wrong thinking time was shorter than that in the pseudo stimulation group (P＜0.05);The visual span and delayed memory performance of RBANS was significantly increased in the rTMS stimulation group (P＜0.05),and the visual span was significantly higher than that in the pseudo stimulus group (P＜0.05);There were 2 cases of patients with mild symptoms after the first treatment in RTMS stimulation group,all patients were without complaint followed up for 3 months.Conclusion:rTMS treatment on the part of the cognitive function of patients with chronic schizophrenia has a certain improvement effect,and higher security,it is worth further study.