Objective:To evaluate the establishment method and bionomics of VX2 lung cancer models in rabbits.Methods: VX2 tumor fragments,preserved from autoinculation rabbits into the lungs of healthy rabbits to establish the models,and then the tumorous growth was observed through the imageology and the morphology of the samples including the lung,the cardia,the liver,the kidney,the brain and lymphatic gland after death at different time.Results:(1) the achievement ratio of modeling was 100%。(2)The VX2 tumor discovered evidently in lung were displayed for diffuse,inequality of size,tuberculum and fish surface.It was visible that metastatic tumor,which were invasion,were discovered evidently in all six organs except for the brain after vaccination for six days.(3)Squamous cell carcinoma,which was originated from epithelial tissue,was confirmed through pathologic histology and immunohistochemistey.Conclusions:The construction of VX2 tumor animal models in rabbits by applying organism fragments not only is simple in method,free from infection and high in achievement ratio but also the biological behaviour of VX2 is similar to human tumors,with high level of malignancy.This study provides valuable guidance for the construction of the large animal models of the lung cancer.

Objective:To analyze the efficiency and influencing factors of Chinese medical and health resources. Methods:Based on the panel data of 31 mainland provinces from 2003 to 2011 in China, use the two-stage Malmquist-Tobit model to analyze. Results:The efficiency of Chinese medical and health resources shows an increasing trend, which is dual driven by improvement of technical efficiency and technological progress. The efficiency varies among different areas, and the descending order of efficiency value is east, west and center. The level of economic development, population density, the proportion of profitable hospitals, the levels of urbanization and education can promote Chinese medical and health efficiency with different extent. Conclusion:To improve the efficiency of Chinese medical and health resources, it needs to promote economic development level, allocating health resources reasonably, and advancing urbanization and education levels orderly.

Objective To investigate the level of self-management behaviors and the quality of life with gastro esophageal reflux disease(GERD) patients,and analyze the correlation between self-management level and quality of life.Methods A total of 372 GERD patients were investigated by using Self-management Behavior Scale and Mos 36-item Short Form (SF-36) Health Survey.Results The level of self-management behaviors in GERD patients was relatively low.The total score of quality of life was (48.75±7.59) and the scores of the level of self-management behaviors was (5.13±0.59).Correlation analysis showed that there was positive correlation between quality of life and self-management behaviors(r=0.423,P＜0.01).Conclusion To promote the patients' health status,nursing staff should take measures to strengthen patient health education on the level of self-management behaviors for GERD patients.

Objective To evaluate the effect of oral rehabilitation method combined with Shaker exercise on the swallowing function and the quality of life in the patients with dysphagia caused by cerebral infarction.Methods A total of 120 patients with swallowing disorder caused by cerebral infarction were randomly divided into conventional treatment group (n=30),oral rehabilitation method group (n=30),Shaker exercise group (n=30) and comprehensive therapy group (n=30).The patients in the conventional treatment group were treated with conventional treatment,while the patients in oral rehabilitation method group received oral rehabilitation method treatment in addition.The Shaker exercise group accepted Shaker exercise and conventional treatment,while the comprehensive therapy group accepted oral rehabilitation method in addition.All patients were assessed with video fluoroscopic swallowing study (VFSS) and swallowing-related quality of life (SWAL-QOL),before treatment and 4-week after treatment.Results Before treatment there was no significant difference among the four groups in VFSS and SWAL-QOL scores (P＞0.05).After 4-week treatment the swallowing function showed different degrees of improvement.The difference of VFSS score in the conventional treatment group was not statistically significant before treatment and 4-week after treatment (P=-0.38),but it was statistically significant among the other three groups (P＜0.01).After 4-week treatment there was significant difference among the four groups in VFSS score (P＜0.01),and the comprehensive therapy group curative effect was significantly better than that of the other groups.The total effective rate was 96.67％ in the comprehensive therapy group,26.67％ in the conventional treatment group,66.67％ in the oral rehabilitation method group,and 70.00％ in the Shaker exercise group.the SWAL-QOL score in the comprehensive therapy group was higher than that of the other three groups.The average SWAL-QOL score was 187.30±10.68 in the comprehensive therapy group,(140.10±16.62) in the conventional treatment group,(161.47 ±24.53) in the oral rehabilitation method group,and (163.97 ± 23.91) in the Shaker exercise group.Conclusion Application of oral rehabilitation method combined with Shaker exercise in the patients with swallowing disorder caused by cerebral infarction could effectively improve the degree of swallowing disorder and the quality of life.

Objective To investigate the illness uncertainty state of the family members of elder patients with colostomy,explore their correlation with social support.Methods A total of 138 family members of elder patients with colostomy in two hospitals from September 2013 to November 2014 were recruited in this study.The General Information Questionnaire,Mishel Uncertainty in Illness Scale-Family Member Form (MUIS-FM) and Social Support Rating Scale (SSRS) were used to investigate the family members of elder patients with colostomy and analyse the correlation between illness uncertainty of family members and its influencing factors and social support.Results The average total score of illness uncertainty was (72.17±9.44) scores.There was significantly different of the family members of elder patients with colostomy in total uncertainty on degree of education,the relationship with patient,stoma nature and economic conditions (P＜0.05).The average total score of social support was (37.14±5.25) scores.The level of illness uncertainty was negatively associated with social support (r=-0.526,P＜0.01).Conclusions The illness uncertainty was mostly in higher levels in the family members of elder patients with colostomy and was negatively correlated with social support.Clinical practice should improve social support of family members to relieve illness uncertainty,so as to provide better services of family and promote physical and psychological rehabilitation of patients.

Objective To analyze the effect of applying KTH [knowledge-attitude-belief practice model (KABP model), transtheoretical model of behavior (TTM) and health belief model (HBM)] integrated health education into nursing of elderly patients with hypertension in institutions in poor areas. Methods KTH integrated health education was established. Before the intervention and 12 weeks after intervention, the Questionnaire of Hypertension Knowledge, the Primary Hypertension Patients′Compliance Scale and Chinese version of the World Health Organization Quality of Life Questionnaire (WHOQOL-100) were used to investigate 84 cases of elderly patients with hypertension of four pension institutions in three poverty-stricken counties of Chaoyang city. Results After 12 weeks of intervention, the awareness rate of hypertension knowledge, compliance behavior and quality of life scores were higher than those before intervention, the complete awareness rate was 100.0% (84/84) vs. 3.5% (3/84);the high level of compliance behavior was 48.8%(41/48) vs.15.5%(13/84),the difference was significant (χ2=156.41, 86.27, P<0.01). The total score of quality of life was 86.95±5.41, higher than that before the intervention (76.93±6.60), the difference was statistically significant (t=8.662, P<0.01). Conclusions KTH integrated health education is an effective way to be applied in pension institutions of poor areas.

Objective To explore the relationships among psychological empower, role stressors and job burnout in nurses.Methods From February to October of 2014, by random sampling method, 420 nurses from three hospitals of Jinzhou city of Liaoning province were selected and assessed with the psycho-logical empower questionnaires,the job burnout questionnaire,role stressors questionnaire.The data were ana-lyzed using pearson correlation analysis and logical multiple linear regression analysis.Results The average score of job burnout was (59.58±18.30) points, the average score of psychological empower was (38.87±7. 05) points.Job burnout and each dimension were negative correlated with self-determination of the psycho-logical empower ( r=-0.25--0.34, P<0.05) and self-efficacy ( r=-0.08--0.53, P<0.05).The scores of role stressors were positively correlated with the scores of emotional exhaustion( r=0.17-0.43, P<0.05) and cynicism ( r=0.07-0.46, P<0.05) .Multiple regression analysis showed that age(β=-0.104) ,education lev-el(β=-0.237),seniority(β=-0.334),self-determination(β=-0.152),self-efficacy(β=0.127),role am-biguity(β=0.284),role overload(β=0.325) were influencing factors of nursing burnout.Conclusion -Nurses role stressors and psychological empower can predict nurses’ burnout, so nurse managers can in-crease the level of authority to relieve psychological job burnout by reducing caregiver stress source.

Objective To analyze the recent condition on medication safety of the elderly with chronic diseases in poor areas of Liaoning Province, the structural equation model(SEM) was used to investigate the influencing factors of the medication safety in order to provide the scientific basis for medication safety and the rational use of drugs. Methods The 1 690 elderly with chronic diseases in poor areas of Liaoning Province were selected by the multi-stage random sampling and investigated with the self-designed questionnaire, the database was established on SPSS17.0, the model of structural equation modeling was built by AMOS17.0. Results The four common factors, which were the knowledge,attitude, practice and adherence of medication safety, were extracted by confirmation factor analysis, and the data of the four common factors was fitted, the fitting parameters were: χ2/DF=2.254, GFI=0.913, NFI=0.909, CFI=0.925, AGFI=0.825, RMSEA=0.062, the model fitting was ideal. Conclusions The medication of the elderly with chronic diseases in poor areas of Liaoning Province exists potential security risks, the knowledge, attitude, practice and adherence of medication safety are the important factors which affect the medication safety, the health education about medication safety should be conducted in the elderly with chronic diseases in the poor areas, to develop the safety, effectiveness and economy of medication among the elderly.

Objective To explore the effect of hyperbaric oxygen combined with progressively controlled decompression on the prognosis of patients with emergency craniocerebral trauma.Methods Ninety-six patients with emergency craniocerebral trauma were selected as study subjects,and they were divided into observation group (n =50) and control group(n =46) according to the random number table.The observation group was treated by progressively controlled decompression combined with hyperbaric oxygen,while the control group was treated by standard large trauma craniotomy combined with hyperbaric oxygen.The incidence of perioperative complications,prognosis (evaluated by GOS) and activities of daily living(evaluated by ADL) were compared between the two groups.Results In the observation group,the incidence rates of perioperative acute encephalocele,delayed hematoma and postoperative cerebral infarction were 6.0％,10.0％,6.0％,respectively,which were lower than 19.6％,26.1％,21.7％ of the control group(x2 =4.031,4.255,5.069,all P ＜ 0.05).The good prognosis rate in the observation group was 62.0％,which was significantly higher than 39.1％ in the control group (x2 =5.014,P ＜ 0.05).There was no significant difference in ADL score between the two groups before treatment (t =0.347,P ＞ 0.05).After treatment,the ADL scores of the two groups were increased (t =5.673,8.223,all P ＜ 0.05).Meanwhile,the ADL score of the observation group was higher than that of the control group (t =2.920,P ＜ 0.05).Conclusion The application of progressively controlled decompression combined with hyperbaric oxygen in patients with emergency craniocerebral trauma is conductive to reduce acute encephalocele,bone window brain tissue incarceration,delayed hematoma,postoperative cerebral infarction and other complications.Besides,it can repair the damaged nerve cells,and eventually improve activities of daily living of patients and reduce morbidity and mortality,and the prognosis is better.