Objective:To study therapeutic effect of cilazapril and amlodipine on QT interval dispersion and arrhyth-mia in patients with essential hypertension (EH) .Methods:A total of 120 EH patients complicated with ventricular arrhythmia in our hospital from Mar 2011 to Mar 2014 were enrolled ,randomly and equally divided into cilazapril group and amlodipine group ,the two groups all received routine antihypertensive therapy .Blood pressure ,QT in-terval and arrhythmias were compared between two groups .Results:Compared with amlodipine group ,there were significant reductions in 24h mean systolic blood pressure [24hSBP ,(123.81 ± 17.95) mmHg vs .(104.92 ± 14.25) mmHg] ,24h mean diastolic blood pressure [24hDBP ,(88.31 ± 10.28) mmHg vs .(72.24 ± 8.45) mmHg] ,24hSBP variability [ (11.62 ± 1.34) mmHg vs .(7.34 ± 0.97) mmHg] ,24hDBP variability [ (9.47 ± 1.18) mmHg vs .(5.13 ± 0.72) mmHg] ,QT interval [ (385.1 ± 50.4) ms vs .(342.7 ± 48.5) ms] ,corrected QT interval [ (362.7 ± 50.2) ms vs .(321.8 ± 45.1) ms] and QT interval dispersion [ (34.1 ± 5.1) ms vs .(22.5 ± 3.7) ms] in cilazapril group , P<0.05 or <0.01;ventricular arrhythmia class in cilazapril group was significantly better than that of amlodipine group , P<0. 05. Conclusion:Therapeutic effect of cilazapril is more helpful to reduce blood pressure ,QT interval dispersion and improve ventricular arrhythmia than amlodipine in EH patients complicated with arrhythmia .

[Objective] This paper sums up professor Qi Xianghua's five psychological disorders of TCM scholar thought and clinical experience in diagnos-ing and treating insomnia. [Methods] By the pulse diagnosis, discern the five kings of psychological disorders, including irritable, anxiety, palpitation due to fright, depressed, and an medical record of professor Qi Xianghua is cited.[Results] The syndrome differentiation should be based on the five kings of psy-chological disorders.[Conclusions] Professor Qi Xianghua's five psychological disorders of TCM on treating insomnia are worth to extend and apply.

Based on the analysis of the common problems which exist in the military hospital medical cooperative projects, five countermeasures are put forward. Firstly, the basic principles for cooperation should be grasped accurately. Secondly, the management system should be perfected. Thirdly, the feasibility of the projects should be augmented enough. Fourthly, the clauses of the contracts should be checked strictly. Lastly, the supervision and management should be enhanced actively in the period of the cooperation.

Objective:To investigate the clinical value of electrocardiogram in risk stratification of patients with non-ST segment elevation acute coronary syndrome(ACS).Methods: According to the change of electrocardiogram, 260 patients with non-ST segment elevation ACS were divided into four groups: ECG-undiagnosed group (n=22), T-wave inversion group (ST-segment depression group), ST-segment depression group (n=118) and normal electrocardiogram group(n=80). All patients were treated with conventional 18-lead electrocardiogram and troponin I(TnI)detection in the four groups. The incidence of cardiovascular events during and after hospitalization was observed. Results: The complex cardiovascular events and recurrent angina attacks in ST segment depression group increased significantly than that in normal ECG group. The difference was statistically significant (x2=5.723,x2=15.680;P<0.05). Multivariate logistic regression analysis showed that TnI positive factors predict the independent value of composite cardiovascular events higher.Conclusion:The patients with ST segment elevation acute coronary syndrome can effectively carry out risk stratification by ECG ST-segment changes and TnI levels, and predict the cardiovascular events. It has higher clinical application value and independent predictive value of TnI positive.

Objective To investigate the effect of transitional care of physical and mental health of the thoracic spinal cord injury and paraplegic patients discharged on its recovery. Methods Randomized controlled analysis of patients in Spine and Spinal Cord Injury Surgery between June 2014 to October 2015, a total of 65 patients with thoracic spinal cord injury and paraplegic were studied, according to hospital mantissa odd and even numbers divided into observation group (35 cases) and control group (30 cases). The observation group was instituted to extending posthospital care, not the control group. The self-care ability and psychological state were evaluated by Function Independent Measure (FIM), Hamilton Anxiety Scale(HAMA), Hamilton Depression Scale (HAMD)within discharge and in 3 months. And the incidence of complications between the two groups were compared. Results At discharge, the difference of FIM, HAMA, HAMD score between the observation group and the control group was not statistically significant (P>0.05). Discharged after 3 months, the score of FIM, HAMA, HAMD in observation group was(72.35 ± 4.35),(4.80 ± 4.50),(12.13 ± 7.25)points, (63.95 ± 5.02),(10.15 ± 4.91), (19.48 ± 8.31)points in control group. The difference between the two groups was statistically significant (t=-4.798, 3.524, 3.110, P<0.01). There was no significant difference in the incidence of pulmonary infection and blood clots between two groups (P > 0.05); The incidence of urinary tract infection, pressure ulcers, constipation were 8.57% (3/35), 5.71% (2/35), 17.14% (6/35) in observation group, 40.00% (12/30), 33.33%(10/30), 63.33%(19/30) in control group, there were significant differences between, two groups (χ2= 4.324, 4.219, 5.337, P < 0.05). Conclusions Transitional care can significantly improve the psychological state of patients with thoracic spinal cord injury and paraplegia discharged, reduce the incidence of complications and improve quality of life.

Objective To determine the best extraction process of ginkgo leaves with the total transfer rate of total flavonol glycosides and terpene lactones as the index.Methods The effects of ethanol concentration, solid-liquid ratio and extraction time on extraction process were investigated by orthogonal design method, and the contents of total flavonol glycosides and terpene lactones were detected by HPLC to calculate transfer rate.Results The optimum extraction conditions were as follows:85% ethanol refluxing and extracting for three times;the first time extracting with five-fold amount of solvent (V/W) for 3 hours;the last two times with three-fold solvent (V/W) for 2 hours.Conclusion This extraction process has the advantages of simplicity of operator, reason, energy conservation, high efficiency, and is suitable for industrial production.

The physiological and bio-marker function of D-acidic amino acids is now becoming the hot topic on metabolomics study and new drug discovery. A fully automated two-dimensional high performance liquid chromatography (2D-HPLC) system was established by using monolithic ODS column as the first dimension column, acetonitrile-trifluoro acetic acid-water (9: 0. 05: 92, V/ V) as the mobile phase; micro Chiralpak QD-1-AX column as the enantiomer separation column, 10 mmol/ L citric acid in methanol-acetonitrile (50: 50, V/ V) as the mobile phase for the second dimension, 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) as the fluorometrical derivative reagent. The separation efficiency ( Rs > 2. 5), determination sensitivity ( LOD =1 fmol) of acidic amino acids enantiomers were higher than those of existing methods, and an online confirmation of the enantiomers amounts was also achieved using this system. The recoveries were around 97-104% , RSD values for intra-day and inter-day precision were less than 5% for the acidic amino acids enantiomers in the biological samples. Furthermore, by analyzing the aging model senescence accelerated mouse prone 1 (SAMP1) mice which have low immunocompetence, the amounts of D-aspartic acid in thymus and spleen were determined as (206±18) and (264±21) nmol/ g, respectively. It is the first time that an obvious trend of the increasement of D-aspartic acid (p<0. 01) was observed in thymus and spleen of SAMP1 mice compare to senescence accelerated mouse resistant 1 (SAMR1) mice.

OBJECTIVE: To discuss the feasibility of the General Regulations for the Processing of Crude Drugs in the supplement in China Pharmacopeia. METHODS: The problems existing in the General Regulations for the Processing of Crude Drugs in the supplement in China Pharmacopeia were analyzed, aimed at which, some constructive suggestions were presented. RESULTS & CONCLUSION: It's urgent to improve the feasibility of the General Regulations for the Processing of Crude Drugs in the supplement in China Pharmacopeia and standardize the production of Chinese cut crude drugs.

BACKGROUND:Hip segmentation based on CT image has been widely used in computer-assisted surgery planning, prosthesis design and finite element analysis. OBJECTIVE:To explore application effects of automatic segmentation method for hip joint based on Bayesian Decision Theory in computer-assisted hip surgery. METHODS:An accurate outer surface segmentation and extraction remain chal enging due to deformed shapes and extremely narrow inter-bone regions. In this paper, we present an automatic, fast and accurate approach for segmentation of femoral head and proximal acetabulum. The outline of the femur was segmented and extracted by contrast enhancement, thresholding algorithm and region growth algorithm. The boundaries of the bone regions are further refined based on Bayes decision rule. RESULTS AND CONCLUSION:Automatic segmentation method for hip joint based on Bayesian Decision Theory is an accurate segmentation technique for femoral head and proximal acetabulum and it can be applied in computer-assisted hip surgery and prosthesis design.

Constipation is a major gastrointestinal complication after stroke.Its prevalence is from 22.9％ to 60％.It not only influences the quality of life of patients and restricts their social activities,but also causes poor outcomes.Poststroke constipation is associated with various factors,including the use of multiple drugs,dehydration,and inactivity.Its treatment strategies have based on the experiences and expert opinions.The available evidence suggests that nurse-led intervention may improve defecation process.