Objective Comparative analysis of pressure in the compress interlocking intramedullary nail and interlocking intramedullary nail in the treatment of tibial shaft fracture stress level changed.Meth-ods Collection of 44 cases of tibial specimens were divided into two groups:A group :normal tibial inter-locking fixation group locking intramedullary nail .B group :internal fixation group locking intramedullary nail.Analyze and measure the biomechanical properties of the system.Results Pressure in a fixed group of interlocking intramedullary nail fixation group and normal tibial interlocking intramedullary nail in compres-sive interlocking intramedullary nail fixation of superior performance,low stress shielding,has more obvious advantage in strength,stiffness and stability,at the same time,it can make the tibial stump maintain normal stress level,and the operation is convenient,not easy to broken nails.Conclusions Internal compression interlocking intramedullary nail can control the physiological stress and conduction,the broken end of tibia stress level close to the normal stress level,to solve the clinical internal fixation fracture without stress con-duction problem,and can effectively control the harmful stress,low stress shielding,when fixed intramedul-lary fixation device before a new generation of tibial fracture.