Objective To observe clinical curative effect of of aspirin combined with clopidogrel therapy in the treatment of diabetes complicating acute cerebral infarction.Methods 64 patients with diabetes combined with acute cerebral infarction were selected and randomly divided into combined treatment group(32 cases)and control group(32 cases),and the joint treatment group on the basis of conventional treatment was given aspirin and clopi-dogrel treatment,the control group on the basis of conventional treatment was given aspirin therapy.14 days before treatment and after treatment,the nerve function defect score(NIHSS)was evaluated,the Barthel index was used to assess daily life ability of patients.The clinical curative effect and adverse reactions of the two groups were observed. Results Before treatment,NIHSS scores in the combined treatment group and control group were (10.59 ±4.40), (10.63 ±4.35)respectively,Barthel index were (29.40 ±11.50),(28.50 ±12.05)respectively.After treatment, NIHSS scores in the combined treatment group and control group were (5.65 ±1.52),(10.63 ±4.35)respectively, Barthel index were (70.60 ±16.50),(51.65 ±11.45)respectively.NIHSS score was lower than before treatment in the two groups (t =11.48,P <0.01,t =3.10,P <0.01),Barthel index was higher than before treatment(t =44.04, P <0.01;t =27.01,P <0.01),those of the combination therapy group were improved more significantly than the control group (t =12.06,P <0.01;t =19.12,P <0.01).Intracranial hemorrhage and serious adverse reactions were not observed in the two groups.Conclusion The curative effect of aspirin in combination with clopidogrel dual anti-platelet therapy in the treatment of diabetes and acute cerebral infarction was better than aspirin alone,and has better security.

In the patients with end-stage renal disease (ESRD) with hepatitis B virus (HBV) infection who underwent hemodialysis, the viral load of HBV DNA is relatively low and stable.For this phenomenon, some studies suggest that hemodialysis can reduce the HBV DNA load.The mechanism, which remains unclear, may be as follows: when HBV DNA enters the dialysate through the dialysis membrane, it was adsorbed onto the dialysis membrane;some virus particles were destroyed, and antiviral substances were produced in the course of hemodialysis.At present, there is no consensus on the mechanism responsible for the influence of maintained hemodialysis on the viral load of HBV DNA.This article reviews the factors involved in the influence of maintained hemodialysis on the viral load in ESRD patients with HBV infection and the recent progress.

Objective To investigate arthroscopic characteristics and minimally invasive treatment of meniscal injuries in osteoarthritic knees. Methods Sixty-eight cases of meniscal injuries in osteoarthritic knees were divided into four types according to arthroscopic characteristics of meniscal tears and involvement degree of the synovium and the cartilage: Type Ⅰ: limited meniscal injuries; Type Ⅱ: Limited injuries combined with abrasive injuries; Type Ⅲ: injuries of the most part of the meniscus, loose meniscus; Type Ⅳ: abraded meniscus combined with partial or mostly partial absence. Corresponding arthroscopic procedures were performed. Results Among the 68 cases, there were 10 cases of the Type Ⅰ injuries, 20 cases of the Type Ⅱ, 27 cases of the Type Ⅲ, and 11 cases of the Type Ⅳ, respectively. For the Type Ⅰ injuries, arthroscopic meniscal suture was performed in 4 cases and partial arthroscopic meniscectomy was performed in 6 cases. For the Type Ⅱ injuries, arthroscopic partial meniscectomy was performed in 18 cases and subtotal meniscectomy was performed in 2 cases. For Type Ⅲ injuries, arthroscopic lavage and debridement was performed in 1 case, arthroscopic partial meniscectomy in 5 cases, subtotal meniscectomy in 16 cases, and total meniscectomy in 5. For Type Ⅳ injuries, arthroscopic subtotal meniscectomy was performed in 2 cases and total meniscectomy in 9 cases. A follow-up was carried out for 6~52 months (mean, 22 months). There were 7 cases of pain after vigorous activities (Type Ⅱ: 1 case; Type Ⅲ: 2 cases; Type Ⅳ: 4 cases), 1 case of locking knee (Type Ⅲ), and 2 cases of limitation of knee flexion (Type Ⅲ and Ⅳ: 1 case each). Total knee replacement was conducted 2~3 years after the procedure in 3 cases (Type Ⅲ: 2 cases; Type Ⅳ: 1 case). Of the remaining 65 cases, the Lysholm scores were elevated from 50?12 preoperatively to 85?8 postoperatively (t=3.521, P

Objective To research the optimal test condition for determining TVOC in air based on GB 50325-2001 Code for Indoor Environmental Pollution Control of Civil Building Engineering. Methods Seven kinds of standard gas (benzene, toluene, ethylbenzene, p-dimethylbenzene, m-dimethylbenzene, ethenylbenzene and o-dimethylbenzene) were injected into Tenax-TA sampling tube, then heated for different time and pyrolyzed for different time. Results Tenax-TA sampling tube was heated for 30 seconds and pyrolyzed for 90 seconds. The recovery rate of seven kinds of compounds was more than 90%. Relative standard deviation was less than 10%. Conclusion The optimal test condition for determining TVOC in air has been presented in this paper. The precision and sample recovery rate will meet the requirement of indoor air quality standard annex A Indoor Air Monitoring Technology.

Objective: To investigate the effects of pentoxifylline (PTX) on oxygen free radicals induced myocardial injury. Method: An in vivo myocardial impairment model was developed in SD rat with exogenous oxygen free radicals. The changes cardiac performance and serum malonylaldehyde (MDA), lactic acid, cretine phosphokinase (CK) levels were tested before and at different interval after I. V. administration of oxygen free redieal. Result: Myocardial performance after oxygen free radicals administration was significantly depressed compared to the baseline values (P

Objective To evaluate the efficacy of PTX on the global cerebral ischemia reperfusion injuryMethods The global cerebral ischemia of gerbils was induced by clamping bilateral carotid arteries for 30 min , then declamping with the reperfusion lasting 90 min At the beginning of ischemia , PTX 25mg?kg -1 or 50mg?kg -1 was administered intravenously by mini infusion pump In another group , PTX 25mg?kg -1 was infused at the beginning of reperfusion In sham operated and control groups the same volume of 0 9% NaCl were infused 0 2% Even's blue 1ml?100g -1 was injected intraperitoneally At the end of experiment , The gerbils were decapitated to be preserved at -70℃ for measurement of water contents of whole hemispheres , cerebral superoxide dimutase (SOD) activity, malonyldialdehyde (MDA) content and Even's blue content Results As compared with those in control group, at the beginning of ischemia or reperfusion ,the administration with PTX 25mg?kg -1 significantly reduced the cerebral water content (P

Specific primers were designed according to published nucleotide sequence of FABP (fatty acid binding protein) gene in the GenBank database. The kozak sequence (CCACC) was introduced at the upstream of initiator. The total RNA was extracted from protoscoleces of Echinococcus granulosus (Inner Mongol isolate). The FABP gene cDNA fragment was amplified by RT-PCR and cloned into pMD19-T vector for sequencing and analyzing. The cloned FABP gene cDNA was with 402bp. The ORF encoded 133 amino acids. The amplified cDNA fragment was subcloned into pCDNA3.1(+)vector. The results showed that the nucleic acid vaccine candidate pcDNA-FABP-NM has been constructed.

Objective To evaluate the clinical significancy of laparoscopic intrafascial hysterectomy. Methods We reviewed 37 cases of laparoscopic intrafascial hysterectomy and 45 cases of open intrafascial hysterectomy. A controlled study on operative time, blood loss, time to first flatus, postoperative morbidity and complications was made. Results All operations in two groups were successfully completed, and no severe complications were seen. In laparoscopic group and open group, the operative time, blood loss, time to first flatus, and postoperative morbidity were (158?36.7) min and (99?24.3) min (t=8.714, P

Objictive To reform the method of biochemical teaching.Method The classes of grade 07 were divided into test classes and control classes and medical cases were used in test classes at the beginning of the class while the traditional mode was used in control classes.Results The learning interesting was markedly improved in test classes.The test results of test classes was significantly higher than the control classes,P

Objective To investigate the effect of establishing external device quality management system in the operating room of primary hospital.Methods 100 pieces external orthopaedic surgical instrument cleaned and packaged by company personnel in 2012 were randomly selected as control group,and 100 packages of orthopaedic surgical instrument cleaned by the professional of our hospital were randomly selected and set as the observation group.The cleaning quality of the two groups were compared.Results The numbers of no blood on the surface,sur-face of the device without rust,instrument storage box no stains,cloth bag no stains in the control group were 92,91, 86,90,respectively,which in the observation group were 99,98,97,98.The cleaning quality improved obviously in the observation group,and there were statistically significant differences between the two groups (χ2 =4.19,471,7.78, 5.67,all P <0.05).Conclusion To establishment of surgical patients external device quality management system in the operating room of primary hospital,standardized management of external devices,can ensure that the management and implementation of quality control of external devices in all aspects and to ensure clinical safety.