Objective To investigate the relationship between perinatal outcome and weight gain of pregnant women with gestational diabetes mellitus (GDM).Methods Ninety-two cases pregnant women with GDM were collected.The rate of weight increasing was recorded throughout the pregnancy and body mass index (BMI) was calculated.Based on the amplitude of packets of body weight increasing,24 cases was selected during pregnancy as insufficient weight gain group,suitable weight gain group of 42 cases,and excessive weight gain group of 26 cases.Their perinatal outcome were compared.Results In excessive weight gain group,the proportion of the gestational hypertension (19.23％) and postpartum hemorrhage (23.07％) were significantly higher than suitable weight gain group and insufficient weight gain group(7.14％,8.33％ and 4.76％,4.17％),the differences were statistically significant (x2 =8.132,10.453,P ＜ 0.001).Among the three groups,no significant difference was found in terms of the incidence of anemia (3.85％,4.76％,4.17％),preterm labor (7.69％,7.14％,8.33％),premature rupture of membranes (11.54％,11.90％,12.50％) in pregnancy (P2 =0.572,0.492,0.212,P=0.63 1,0.692,0.783).The huge birth weight children rate in excessive weight gain group(15.38％) was significantly higher than suitable weight gain group and insufficient weight gain group (4.76％ and 4.17％).Among three groups,no significant difference was found in terms of the fetal distress (15.38％,16.67％,12.50％) and proportion of low birth weight children (3.85％,4.76％,4.17％) (P2 =1.034,0.572,P =0.310,0.631).Conclusion Excessive weight gain during pregnancy in GDM patients will significantly increase the gestational hypertension,the incidence of huge children and postpartum hemorrhage.Therefore,patients should be closely monitored during pregnancy weight and timely taken intervention.

OBJECTIVETo explore the better therapy for chronic tension-type headache (CTTH).

METHODSTwo hundred and eighty-eight cases were randomized into a sticking needling group (150 cases) and an acupuncture group (138 cases). In the sticking needling group, the manual sticking needling technique was adopted to stimulate the galea tendon-muscle node. In the acupuncture group, the conventional acupuncture therapy was applied to Baihui (GV 20), Sishencong (EX-HN 1), Fengchi (GB 20), Taiyang (EX-HN 5), Touwei (ST 18), Hegu (LI 4), etc. The treatment was given once a day, and 30 days made one session. After two sessions of treatment and after three months follow-up, CTTH score (including the score of headache attack frequency and the score of headache severity) was observed and compared before and after treatment separately. The efficacy was evaluated in two groups.

RESULTSCTTH score was all reduced after treatment in the two groups (both P<0.01), the score in the sticking needling group was lower than that in the acupuncture group (2.38 +/- 1.22 vs 4.16 +/- 2.54, P < 0.01). The effective rate was 97.3% (146/150) in the sticking needling group, which was better than 88.4% (122/138) in the acupuncture group (P < 0.05).

CONCLUSIONThe manual sticking needling technique at galea tendon-muscle node achieves the superior results of reducing the pain attack frequency and severity of CTTH as compared with the acupuncture therapy of the routine acupoint selection.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Female ; Humans ; Male ; Middle Aged ; Muscles ; physiopathology ; Tendons ; physiopathology ; Tension-Type Headache ; physiopathology ; therapy ; Treatment Outcome

OBJECTIVE: To compare the therapeutic effect of different animal bile powders on lipid metabolism disorders induced by high-fat diet in rats, and analyze the bioactive components of each animal bile powder. METHODS: Sixty Sprague-Dawley rats were randomly divided into 6 groups (n=10): normal diet control group, high-fat diet model group, high-fat diet groups orally treated with bear, pig, cow and chicken bile powders, respectively. Serum biochemical markers from the abdominal aorta in each group were analyzed. Changes in the body weight and liver weight were recorded. Pathohistological changes in the livers were examined. High performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was used to determine the composition of bioactive components in each animal bile powder. RESULTS: Treatment with different types of animal bile powders had different inhibitory effects on high-fat diet-induced increase of body weight and/or liver weight in rats, most notably in bear and pig bile powders (P<0.05). High-fat diet induced lipid metabolism disorder in rats, which could be reversed by treatment with all kinds of bile powders. Bear bile and chicken bile showed the most potent therapeutic effect against lipid metabolism disorder. Cow and bear bile effectively alleviated high-fat diet induced liver enlargement and discoloration, hepatocyte swelling, infiltration of inflammatory cells and formation of lipid vacuoles. Bioactive component analysis revealed that there were significant differences in the relative content of taurocholic acid, taurodeoxycholic acid and ursodeoxycholic acid among different types of animal bile. Interestingly, a unique component with molecular weight of 496.2738 Da, whose function has not yet been reported, was identified only in bear bile powder. CONCLUSIONS Different animal bile powders had varying therapeutic effect against lipid metabolism disorders induced by high-fat diet, and bear bile powder demonstrated the most effective benefits. Bioactive compositions were different in different types of animal bile with a novel compound identified only in bear bile powder.
Animals ; Bile/metabolism* ; Biomarkers/metabolism* ; Body Weight ; Cattle ; Diet, High-Fat ; Female ; Lipid Metabolism ; Lipid Metabolism Disorders/metabolism* ; Lipids/analysis* ; Liver/metabolism* ; Powders ; Rats ; Rats, Sprague-Dawley ; Swine ; Taurodeoxycholic Acid/metabolism* ; Ursidae/metabolism* ; Ursodeoxycholic Acid/metabolism*