Child ; Early Diagnosis ; Hand, Foot and Mouth Disease ; diagnosis ; Humans

Objective To identify the chemical components of traditional Chinese medicine by liquid chromatography-mass spectrometry.Methods Chemical components of 86 traditional Chinese medicines were identified by two methods,observation group with LC-MS method and control group with traditional LC methods.The identification efficacy,accuracy,and identification time between two methods were compared. Results The excellent rate in observation group was 76.74% (66/86),the excellent and good rate was 90.70%(78/86),which were significantly higher than those in control group (P<0.05 ).83 kinds of traditional Chinese medicine were successfully identified in observation group,the success rate was 96.5 1%,significantly higher than control group(P<0.05).The identification tine,retention time after correction of errors in observation group were significantly less than control group(P<0.05 ).Conclusion LC-MS has high accuracy,short identification time and wide adaptation range in identification of chemical components of traditional Chinese medicine.

OBJECTIVE:To provide reference for the rational drug use and glycemic control for patients with type 2 diabetes. METHODS:160 patients with type 2 diabetes in 3 communities of Tianjin were divided into 2 groups based on the understanding of the diabetic knowledge,group A(86 cases)had understanding of diabetic knowledge and group B(74 cases)had no. They were carried on the questionnaire survey about the general information,medication and glycemic control. RESULTS:A total of 160 ques-tionnaires were conducted,and 160 were effective with the effective rate of 100%. The proportion of patients with highly educated (college or above)in group A was significantly higher than group B,low education(secondary or below)was significantly lower than group B(P<0.05). The proportion of patients with medicine background in group A was significantly higher than group B(P<0.05). There were no significant differences in the use ratio of different types of drugs for diabetes between group A and group B (P>0.05),however,the use ratio of self-purchase functional food in group A was 0,and group B(60.8%)was significantly high-er than group A(P<0.05). The recent self-test average blood glucose levels,the average blood glucose levels in the investigation day,the 2 h postprandial blood glucose and glycosylated hemoglobin levels in group A were significantly lower than group B(P<0.05). CONCLUSIONS:The medication and glycemic control of patients with type 2 diabetes is closely related to the understand-ing of glycemic knowledge. Therefore,propaganda and education of medication and related functional food for patients need to be strengthened to promote the rational medication.

Adolescent ; Adult ; Aged ; Chilblains ; therapy ; Female ; Ginger ; Humans ; Male ; Middle Aged ; Moxibustion ; Seasons ; Young Adult

Objective:To evaluate the efficacy and safety of itraconazole in the treatment of fungal infection in the patients with hematological malignancies.Method:53 patients with malignant hematologic diseases were divided into three groups:empirical treatment group, suspected fungal infection group and established group.Itraconazole was given in a dose of 200mg twice daily in the first and the second days, from the third day in a dose of 200mg once daily.Response was established as normalization of temperature in the patients receiving itraconazole, and disappearance of clinical signs in the patients with suspected or established infection.Result:The 31 patients were eligible for efficacy evaluation for empirical treatment,and 25 responded to itraconazole(80.65%);of 9 established patients,6 responded to itraconazole(66.67%);of 13 suspected infection patients, 10 responded to itraconazole(76.92%).As to the side effects, there were no rigor and fever, but hepatotoxiciy were present in 5.66%, and no nephrotoxicity.Conclusion:Itraconazole is a highly effective drug with low side effects in treatment of fungal infections.But the hepatic and renal function tests must be carried out regularly when itraconazole infection is used.

Objective To explore the recurrence-prevention effect of oral contraceptive and levonorgestrel-releasing intrauterine system (Mirena) after hysteroscopic endometrial polypectomy.Methods One hundred and seventy-four patients who received hysteroscopic endometrial polypectomy were enrolled in this research.The patients were informed and divided into three groups according to their selection:51 cases were given oral contraceptive since one month until 12 months after the surgery (oral contraceptive group); 60 cases were received Mirena since one month after the surgery (Mirena group) ; and 64 cases were received no treatment after the surgery (control group).The groups were followed up at 3,6,12 months after the surgery and compared the recurrence rate,menstruation,level of hemoglobin and complication rate.Results The recurrence rate in oral contraceptive group,Mirena group and control group was 3.9％(2/51),3.3％ (2/60) and 19.0％ (12/63),respectively.The recurrence rate in control group was higher than that in oral contraceptive group and Mirena group,and there was significant difference (P ＜ 0.05).The proportion of low menstruation volume in control group was lower than that in oral contraceptive group and Mirena group,and there was significant difference (P ＜ 0.05).The level of hemoglobin in control group was lower than that in oral contraceptive group and Mirena group [(124.55 ±9.33) g/L vs.(133.71 ± 11.03),(135.89 ±6.88) g/L],and there was significant difference (P ＜ 0.05).The incidence of complication in Mirena group [18.3％ (11/60)] was less than that in oral contraceptive group[35.3％(18/51)],and there was significant difference (P ＜ 0.05).Conclusions Oral contraceptive and Mirena after hysteroscopy for endometrial polys significantly decrease the recurrence rate.The complication rate of Mirena is lower and it is a safe and effective way to treat and prevent the endometrial polyp.

Objective To explore if the expression of follicle-stimulating hormone ( FSH ) and its receptor ( FSHR) exist in the rat submandibular gland tissue , which may provide a theoretic evidence for further studying on adjusting function of the FSH in submaxillary gland .Methods Twenty normal SD rats , with a mean body weight of (200 ±20)g, were adopted to collect out the submandibular gland after abdominal cavity anesthesia .The method of in situ hybridization was employed on cellular localization of FSH and FSHR .RT-PCR was used to detect if FSH and its receptor mRNA exist in the rat submandibular gland .RNA was extracted from the submandibular gland , then FSH and the core cDNA of its receptor gene were obtained with reverse transcription polymerase chain reaction and analyzed on its sequence . Results The epithelial cells of serous acinus and granular convoluted tubule in submaxillary gland of rats had FSH and FSHR mRNA hybridized signals , which were detected in cytoplasm with negative nuclei .Specific bands of FSH cDNA and FSHR cDNA were identical to be 193bp and 413bp respectively.Conclusion FSH and FSHR can be synthesized by the epithelial cells of serous acinus and granular convoluted tubule in submaxillary gland of rats , thus this study further proves that the submandibular gland is the target organ of FSH .

Insulin-like growth factor receptor type 1 (IGF-1 R) is the receptor cascade effect molecules of IGF signaling pathways in the hypothalamus-pituitary-growth hormone axis.In recent years,IGF-1R gene mutation of short stature case reports increased year by year,now the progress of IGF-1R gene defects in short stature for clinicians was summarized.

Objective To explore the risk factors for in stent stenosis (ISR) in coronary artery disease in elderly patients undergoing postoperative percutaneous coronary intervention (PCI).Methods We chose 418 cases undergoing PCI in our hospital.There were 263 males and 156 females,aged from 60 to 79 years,average (71.3--8.9)years in this study.Under the same conditions of treatment strategies,we collected all possible risk factors for ISR in patients undergoing postoperative PCI,and statistics were analyzed.Results All patients were rechecked at 1 year after PCI.104 cases (24.9％) occurred ISR,and 314 cases (75.1％) were diagnosed without ISR.Multiple logistic analysis showed that,and sex had little effect on ISR incidence (P＞0.05).Body mass index(OR=9.54,95％CI:6.542～32.154,P=0.002),smoking history(OR=26.01,95％CI:5.532～122.238,P=0.000),hypertension(OR=15.72,95％CI:3.240～76.026,P=0.001),diabetes mellitus(OR=11.98,95％CI2.667～53.835,P=0.001),history of high cholesterol(OR=8.98,8,95％CI2.164～37.283,P=0.003),exercise time (OR 5.63,8,95 ％ CI2.004 ～ 25.385,P=0.013)had positive correlations with ISR incidence.Conclusions Effective control of risk factors including smoking,hypertension,diabetes,high cholesterol,proper exercise,and weight control can help prevent the development of ISR in elderly patients with postoperative PCI.

Objective: To analyze the regulation of hospital accounting procedure under the new hospital accounting system. Methods: Summarize the achievement in accounting and find the existing problems by field investigation. Results: Because the content of accounting system reform is big and the requirement is high, the accounting is not in coincident. Conclusion: Since there is imperfection in accounting and unrelated accounting procedure, it is needed to repeat, clarify and unify the management, so as to standardize the hospital financial behavior and reflect the accounting information accurately.