The fibrovascular membrane of proliferative diabetic retinopathy(PDR)cause severe damage to the structure and function of eye.The pathogenesis and development of fibrovascular membrane are associated with muhipie cellular factors,such as transforming growth factor(TGF),connective tissue growth factor(CTGF),basic fibroblast growth factor(bFGF),vascular endothelial growth factor(VEGF),platelet-derived growth factor(PDGF),tumor necrosis factor(TNF),extracellular matrix(ECM),matrix metalloproteinases(MMPs),endothelin and chemotactic factor,etc..So,the molecular mechanism of fibrovascular membrane of PDR is extremely complex.The relationship of pathogenesis on the fibrosis of PDR to cytokines,extracellular matrix,MMPs and other factors were summarized.

DNA, Neoplasm ; analysis ; Female ; Flow Cytometry ; Humans ; Hydatidiform Mole ; diagnosis ; genetics ; In Situ Hybridization, Fluorescence ; Microsatellite Repeats ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Pregnancy ; Triploidy ; Uterine Neoplasms ; diagnosis ; genetics

Aim To examine the protective effects of allopregnanolone against seizure on different animal models.Methods The protective effects of allopregnanolone against maximal electrical seizure (MES) and picrotoxin-induced seizure were studied in C57 mice 15 minutes after vehicle or drug intraperitoneal administration.Results In the MES test, we found that pretreatment with the phenobarbital or allopregnanolone produced a dose-dependent protective effect against seizure. The potency (ED50 value) of phenobarbital in the MES test was 2.40 mg?kg-1, with 95% confidence interval range from 1.22 to 4.72 mg?kg-1. The potency (ED50 value) of allopregnanolone in the MES test was 0.086 mg?kg-1, with 95% confidence interval range from 0.037 to 0.201 mg?kg-1, which was significantly higher than that of phenobarbital (P

Choroidal neovascularization (CNV) ithe leading cause of vision disordecaused by variouretinal diseases.Apresent,many therapeutimethodare employed clinically,such aphotodynamitherapy (PDT),anti-vasculaendothelial growth facto(anti-VEGF) and transpupillary thermotherapy (TTT).However,none of them can cure CNV thoroughly and repeated treatmenirequired usually.The reason forecurrenCNV istill unclear.Choroidal hypoperfusion associated with Pdmay be one of the reasons.The purpose of thireview ito discusthe problem of choroidal hypoperfusion associated with PDfoCNV awell aitimpacon the eye and possible solutions.Thipapepresentevidenceof choroidal hypoperfusion aftePDand itrelationship with clinical outcomes.Meanwhile,the effecof combination therapy iassessed.Finally,low-fluence Pdirecommended apotential method to reduce choroidal hypoperfusion.

Biomarkers, Tumor ; blood ; DNA, Neoplasm ; blood ; Humans ; MicroRNAs ; blood ; Molecular Diagnostic Techniques ; Neoplasms ; blood ; diagnosis ; Nucleic Acids ; blood

Objective To study the effects of metallothionein(MT) egg-milk power on excluding lead in vivo in saturnic rats.Methods A total of 60 Wistar rats were randomly divided into four groups: control(n=20),black control(n=10) and lead-treated groups(n=30).After the rats in lead-treated group were treated with 0.2% lead acetate daily for three weeks,they were randomly divided into two groups: lead-treated group(n=10) and MT egg-milk power treated group(n=20).The rats in the last group were treated with MT egg-milk power for three weeks.At the end of the experiment,samples of whole blood,liver,kidney,brain,femur,faeces and urine were collected for lead detection by atomic absorption spectroscopy.Results As compared with controls,the lead content of samples were significantly elevated in lead-treated rats(P

Objective To understand the endemic situation of schistosomiasis among 80 national surveillance sites for schistosomiasis in 2006,so as to provide scientific evidence for making out schistosomiasis prevention and control measures. Methods According to the national surveillance protocol, the endemic situation of schistosomiasis in residents and livestock, and the status of Oncomelania snails and other factors were investigated in the 80 national surveillance sites for schistosomiasis, and all the data were collected and analysed. Results Among the 80 national surveillance sites,the average positive rate of residents with sera examination was 13.60% and the average positive rate with stool examination was 1.59%.The average positive rate of floating population with sera examination was 5.79%. There were 143 advanced patients among the national surveillance sites, and 12 acute patients were reported in 2006, but no breaking-out epidemic reported. The proportion of domestic animals stable breeding were about 4.74% of 5 365 examined animals in 2006, and the others were not.The infection rate of domestic animals was 5.93% that declined by 34.49% compared with that in 2005 and especially for the infection rate of cattle and sheep. A total of 7 429.63 hm2 of areas were surveyed. The areas of snail habitats, infected snail habitats and the new snail habitats were 4 994.01,621.75 hm2 and 21.75 hm2,respectively. The density of living snails and infection rate of snails were 0.544 8/0.1 m2 and 0.37%, which increased compared with infection rate of 0.26% in 2005. Conclusion The endemic situation of residents, cattle and snail habitats declined in 2006 compared with those in 2005 in the national surveillance sites.

Objective To analyze comprehensively the investigation data of the national schistosomiasis surveillance sites from 2005 to 2007, in order to provide the evidence for mastering the endemic situation and pattern of schistosomiasis. Methods Eighty surveillance sites were selected, and the investigation data about schistosomiasis in residents and domestic animals and the status of Oncomelania snails in these sites were collected and analysed. Results From 2005 to 2007, the total infection rate in residents decreased by 54.90% (average decreased by 18.30% each year). The sites where the infection rate in residents was higher than 5% decreased year by year. In 2007, there was no site where the infection rate in residents was higher than 5% in all the 80 surveillance sites. All the infection rates in different age groups decreased for three years in succession, and the peak appeared at 30-50 age group in 2005, but moved to 50-60 age group in 2007. The infection rate in domestic animals decreased by 69.22%, and the infection rate in cattle and buffaloes remarkably decreased. For the three years, the areas with snails reduced by 8.84%, and the areas with infected snails reduced by 53.23%. The average densities of living snails and infected snails decreased year by year, but the infection rate of snails fluctuated during the three years. Conclusion The endemic situation of schistosomiasis in residents and cattle, and the status of snails, in general, remarkably decreased from 2005 to 2007.

Objective To survey and understand the endemic situation of schistosomiasis in China in 2007,so as to provide the evidence for decision-making of schistosomiasis control.Methods The data of investigation on schistosomiasis in residents,domestic animals,Oncomelania snails and other relative factors were collected and analysed in the 80 national surveillance sites,2007. Results In 2007,the total infection rate of the residents was 0.92%,which decreased by 42.31% compared with that in 2006. There was no site where the resident infection rate was more than 5% among all the 80 surveillance sites. The peak of the resident infection rate with different age groups appeared at the 50-60 age group. The cattle and buffalo were still the main infection targets. The infection rate of domestic animals was remarkable decreased. The density of living snails was 0.430 0/0.1 m2. The percentage of frames with living snails was 0.06%. The density of infected snails was 0.000 7/0.1 m2,and the snail infection rate was 0.16%. All of them were decreased compared with those of 2006. Conclusion The schistosomiasis endemic in the residents,cattle and snails was remarkable decresed in the national surveillance sites,2007.