Objective To understand the quality of life of elders in the community of Shangqiu and analyze the affecting factors to provide a scientific evidence which could improve their quality of life.Methods The general questionnaire and World Health Organization Quality of Life Brief Evaluation From were used among 116 elders in two communities of Shangqiu.Results The quality of life of elders was in low level.The mainly factors that influencing the quality of life of elders in the community of Zhengzhou were age,education status,economic income,hobbies and interest,family relation,physical exercise.Conclusions The factors that influence the elders in community are various.To improve quality of life of elders,community workers should take relevant measures and encourage family members to participate in caring elders.

Objective To develop a RP-HPLC method to determine adenosine in Chongcaoqizhi granule. Method The separation was performed in a Kromasil ODS-1 column (250 mm?4.6 mm, 5 ?m) with a mobile phase of phosphate buffer solution (pH 6.5) - methanol (85∶15). The flow was 0.7 mL/min and the detective wavelength was set at 260 nm. Results The standard adenosine showed a good linear correlation at range of 1.016~12.192 ?g/mL. The linear regression equation and correlation coefficient (r) were Y =169339X -82318, r =0.9990, respectively. The average recovery of the loading was 98.02% and the RSD was 1.72%. The average content of adenosine was 12.45 ?g/g. Conclusion This method is accurate, reproducible and highly selective, and can be used for quality control of Chongcaoqizhi granule.

Blood Coagulation Factor Inhibitors ; antagonists & inhibitors ; blood ; Factor VIII ; administration & dosage ; antagonists & inhibitors ; immunology ; Hemophilia A ; drug therapy ; genetics ; immunology ; Humans ; Immune Tolerance ; Isoantibodies ; blood ; immunology ; Recombinant Proteins ; adverse effects ; immunology ; therapeutic use ; Risk Factors ; Time Factors

Biomarkers ; Environmental Monitoring ; Humans

External evaluation of large medical institutions is key to performance management in the medical sector,which is both a major means for the government to manage such institutions and a key guideline for their internal performance management. Based on a study on the pathways of such institutions in the UK,the USA and Japan in their external evaluation of performance,the paper summarized practices of Shanghai,Shenzhen,Zhenjiang and Beijing,in an attempt to offer references for building the external evaluation system for such institutions in China.

Objective To observe and explore the effect of aripiprazole(Ari)and olanzapine(Ola)on body weight and lipid metabolism in schizophrenia(SP)patients.Methods 96 patients with SP were randomly divided into two groups,48 cases in the observation group and the control group.The control group was treated with Ola,while the observation group was treated with Ari.Before and 6 weeks after treatment,the height,body weight,blood glucose (FBG),insulin(INS),low -density lipoprotein(LDL),triglycerides(TG),total cholesterol(TC)levels in the two groups were detected,insulin resistance index(IRI)and BMI were calculated.Results The differences of body weight,BMI,FBG,INS,IRI,LDL,TG,TC before treatment between the two groups were not statistically significant (t =0.161,0.564,0.277,0.078,0.092,0.124,0.421,0.245,all P >0.05).After 6 weeks treatment,FBG,INS, IRI in the observation group were (4.71 ±0.58)mmol/L,(21.85 ±12.36)μU /mL and (4.62 ±2.14),the differ-ences were not statistically significant compared with before treatment(t =0.800,0.571,0.276,all P >0.05).Those in the control group were (5.14 ±0.56)mmol/L,(28.54 ±11.25)μU /mL and (6.23 ±3.82),which were signifi-cantly higher than those before treatment(t =4.898,3.361,2.628,all P <0.05),and were also significantly higher than those in the observation group(t =3.695,2.773,2.547,all P <0.05 ).After 6 weeks treatment,the body weight,BMI,LDL,TG,TC in the observation group were not statistically significant compared with before treatment (t =0.262,0.638,0.124,0.421,0.245,all P >0.05 ),those in the control group were significantly higher than before treatment(t =2.601,3.834,5.773,5.838,4.375,all P <0.05),and were also significantly higher than those in the observation group(t =3.052,3.265,5.264,5.496,4.188,all P <0.05).Conclusion Ari treatment for SP has no significant effect on glucose and lipid metabolism and body weight in patients,and the effect of Ola treatment on patients'body weight and lipid metabolism is more significant.

Objective To observe the influence of mental rehabilitation combined with family intervention on self -efficacy and quality of life of patients with schizophrenia.Methods 92 cases of schizophrenia patients were choosed to be the research object.They were divided into control group (46 cases)and observation group (46 cases) according to random number table method.The control group was given mental rehabilitation while the observation group was given the mental rehabilitation combined with family intervention treatment.The clinical efficacy of the two groups of patients was observed after six months.The patient's self -efficacy was assessed by using self -efficacy scale (GSES),and the patient's quality of life was assessed by using the quality of life scale (QLQ).Results Six months after treatment,the score of PANSS in patients with positive symptoms[(14.19 ±4.16)points],negative symptoms [(16.29 ±4.92)points],mental symptoms[(35.56 ±6.75)points]and total score[(65.84 ±15.83)points]in the observation group were lower,which were better than those of the control group[(17.37 ±5.27)points,(21.11 ± 5.64)points,(42.37 ±7.92)points and (80.85 ±18.83)points],and the differences were statistically significant(t =3.212,4.368,4.438,4.544,all P <0.05).The total effective rate was 86.96% in the observation group,which was significantly higher than 67.39% in the control group,the difference was statistically significant(χ2 =4.998,P =0.025).The self -efficacy scores of the two groups were higher than before the treatment,which of the observation group[(3.51 ±0.62)points]was better than that of control group[(2.13 ±0.48)points],the difference had statistical significance(t =5.593,P =0.000).After treatment,the patient's quality of life score such as emotional function [(59.82 ±11.38)points],cognitive function[(69.43 ±12.32)points],role function[(69.77 ±12.31 )points], physical function[(75.38 ±14.01 )points],social function[(66.28 ±13.03)points]and so on were higher than before treatment[(56.88 ±10.36)points,(42.01 ±9.29)points,(47.02 ±9.17)points,(60.34 ±10.89)points, (53.92 ±10.76)points].Results of the observation group were better than those of the control group[(53.07 ± 10.13)points,(63.02 ±11.17)points,(62.03 ±11.17)points,(67.33 ±11.74)points,(60.87 ±12.62)points], the differences had statistical significance(t =3.005,2.664,3.158,2.987,2.023,all P <0.05).Conclusion Therapy of mental rehabilitation combined with family intervention can improve the clinical curative effect of schizophrenia patients, and improve the patient's self -efficacy and quality of life.It is worthy of clinical popularization and application.

Objective To investigate the potential factors affecting the survival rate of extremely low birth weight infant (ELBWI) and to make out a practical strategy. Methods Fourty-four ELBWI were devided to 3 groups according to their birth weight. All the clinical data were reviewed. Results The survival rate on discharge was 52% (22/42) and the mortality rate was 45%(19/42). The survival rate was significantly increased with higher birth weight( P

Objective To study the imaging of central pentine myelinolysis (CPM) and extrapontine myelinolysis(EPM) after liver transplantation and value of DWI. Methods Eight patients after liver transplantation with CPM and EPM were included in our study, 4 cases of female and 4 cases of male.MR examinations were performed on Philips 1.5 T MRI system. The sequences included SE T1 WI, FSE T2Wl,axial SE-EPI DWI,TR/TE 6225/118.7 ms, ETL 128, FLIP 90°, thickness 5 nun, matrix 128 ×128,b=1000 mm2/s. Results Four of B type hepatitis and cirrhosis and 1 case combined with hepatic carcinoma, 1 of C type hepatitis with cirrhosis from schistosome,2 of C type hepatitis and cirrhosis, 1 of cholangiogenic cirrhosis. MR demonstrated prolongation of T1 and T2 with a shape of butterfly, round or quadrangle on the brain stem sparing of the corticospinal tract and peripontine tissue. The lesion manifested high signal intensity both on DWI and ADC map indicating T2 effect and vasogenic edema. Follow up MR in 2 cases 2 months later showed more prolongation of T1 and T2 than the first time and the lesion manifested iso-intensity signal on DWI and high signal intensity on ADC map suggesting increased diffusivity. Abnormal signal intensities were detected on the bilateral caudate head, globus pallidus, putamen and cerebral cortex in 3 cases. Conclusion CPM should be considered when prolongation of T1 and T2 with a shape of butterfly, round or quadrangle on the brain stem, sparing of the corticospinal tract and peripontine tissue was detected for patients of pest-transplantation. When combined with other area abnormality, EPM and CPM should be considered. DWI can early and sensitively show the lesion.