Objective To investigate the clinical management and therapeutic strategy for patients with pseudobulbar paralysis post stroke. Methods To retrospectively analyze the clinical data of 157 patients poststroke whom were in convalescence stage. Then patients with pseudobulbar paralysis were selected and whose epidemiology feature and treatment effect were analyzed. Results In 157 patients,55 patients(35.0%) were complicated with pseudobulbar paralysis,among whom,26 patients(26/55,47.3%) with hemorrhagic stroke,including basal ganglia hemorrhage 6(6/26,23. 0%) , cerebellar hemorrhage 12 (12/26,46. 2%) and brain stem hemorrhage 8 (8/26,30. 8%).29 patients suffered ischemic stroke(29/55,52.7%) ,including 9 cases with corticalis(9/29,31.0%),13 with brain stem infarction(13/29,44.8%) and 7 with cerebellar infarction(7/29,24. 2%). Among all the patients,32(32/55,58.2%) cases lesion were multiple and 23 cases(23/55,41. 8%) were simple. In the field of treatment effect of all patients,41 cases(42/55,76.4%) were with excellence, 11 with utility(11/55,20%) and 2 with inefficiency (2/55,3.6%). Conclusion The comprehensive management and compatible medical treatment should be the compatible clinical management and therapeutic strategy for patients with pseudobulbar paralysis post stroke.

Objective To compare the clinical effect and scoring of nervous system in treatment with Parkin-son's disease by two treatment methods.Methods 80 cases with Parkinson's disease,using a random number table were randomly divided into Madopar treatment ( control group ) 40 cases and Madopar combined with traditional Chinese medicine treatment (observation group) 40 cases;The cutative effect and score of PDSS,ESS,HAMD,VAS and BI index before and after treatment of the two groups were observed.Results The score of PDSS ( 122.5 ± 16.5)point,(125.7 ±17)point before treatment in observation group and the control group were significantly lower after treatment (138.5 ±16.4)point,(135 ±15)point (t=3.45,4.01,all P<0.05);The score of HAMD (13 ± 7)point,(13.5 ±18.5)point were obviously higher than that after treatment (7.5 ±3.2)point,(7.4 ±5.2)point (t=2.41,2.31,all P<0.05);The BI index (25.44 ±9.11)point,(25.99 ±9.55)point were significantly lower af-ter treatment (60.11 ±9.85)point,(61.22 ±9.99)point (t=4.01,4.03,all P<0.05);The efficiency 87.5%after treatment in observation group were higher than 70%in the control group (χ2 =13.25,P<0.05);The adverse reac-tion 5 cases (12.5%) in observe group were significantly lower than that 10 cases (25.0%)in control group(χ2 =16.21,P<0.05).Conclusion It is safe and effective treatment method in Parkinson's disease by Madopar combined with traditional Chinese medicine treatment.

ObjectiveTo explore the neuroprotective effect of magnesium sulfate in tretment of patients with cerebral ischemic stroke. Methods40 patients with cerebral ischemic stroke were selected and randomly divided into experimental group(20 cases) and control group(20 cases). Among those two groups,the magnesium sulfate therapeutic measure was carried out in the experimental group and the control group was treated without magnesium sulfate. The difference rangeability of level of serum myelin basic protein pre and pro-therapy of both groups was compared. ResultsFor the experimental group, the mean level of serum myelin basic protein in the first day pre-therapy was (8.3 + 2.5) μg/L, and (4.2 ± 1.7) μg/L in 10 days pro-therapy. the csrtrol group was ( 8.0 ± 3.0) μg/L for tite first day pre-therapy,and (6.0 ± 1.4) μg/L in 10 days pro-therapy. The difference rangeability of level of serum myelin basic protein pre and pro-therapy of both groups had statistical significance, compared with the controlled group,the experimental group had lower level of serum myelin basic protein ( t = 1. 231, P = 0. 041 ).ConclusionMagnesium sulfate could significantly decrease the serum level of myelin basic protein for patients with cerebral ischemic stroke,which irdicate that the magnesium sulfate should have neuroprotective effect on patients with cerebral ischemic stroke.

Objective To observe the effect and safety of bFGF auxiliary fractional Er :YAG laser in the treatment of facial a-trophic acne scar .Methods After fractional Er :YAG laser treatment ,64 cases of facial atrophic acne scar patients were randomly divided into two groups ,the observation group was applied facial ice collagen dressing and sprayed fibroblast growth factor ,the con-trol group was only applied facial ice collagen dressing .Treatment in two groups last for 10 consecutive days .Postoperative to ob-serve the wound healing time ,adverse reactions ,using B .Dreno′s ECCA grading scale to identify and quantify facial atrophic scars before and after treatment and statistics the satisfactory rate of patients .Results The wounds of two groups were conventional healing ,in the observation group the average healing time was 7 .2 days ,and that of control group was 10 .4 days ,there was signifi-cant difference (P<0 .05) .For all patients at the end of treatment and followed-up 3 months later ,scar were all improved ,with an efficiency of 100% .Conclusion Fractional Er :YAG laser combined with bFGF is a safe and effective treatment method for treat-ment of facial atrophic acne scars .

Objective:To determinate the resistant starch in different kinds of food so as to provide the data for guiding the diet for health. Method:The contents of resistant starch in 6 kinds of food samples were determined by a method that mimicked gastrointestinal conditions. Results:The contents of resistant starch in raw food were higher than cooked food, except beans. The content of resistant starch of raw potato and deepfrying potato was respectively the highest, 46.06?2.65 g/100g total starch and 29.11?1.52 g/100g total starch. Conclusion:The repeatability of the analysis method was good, and the contents of resistant starch in various kinds of food were different.

Objective Renal papillary cell carcinoma(RPCC) has been historically regarded as a radio-resistant malignancy. However, the molecular mechanism underlying its radio-resistance is not well understood. Recently,STAT1, a transcription factor downstream of the IFN-signalling pathway, has been implicated in radioresistance. This study is to investigate the role of STAT1 in "radio-resistant RPCC". Methods The expression of STAT, in 137 human RPCC samples compared with 15 normal kidney tissues was examined by micrearray expression profiling using the Affymetrix HGU133 Plus 2.0 GeneChip oligonucleotide arrays. For in-vltro experiments, human RPCC cell line(SKRC-39), human fibroblast(CCL-116) and human Wiim's tumor cell line(CRL-1441) were used. Western blotting was performed to evaluate total and phosporylated STAT1 expression. RPCC cells were irradiated and compared to controls in clonogenic assays. STAT1 inhibition either with fludarabine or siRNA was done and their effects on radiation-induced cell survival were investigated. Results The STAT1 expression data shows that there was a significant increase in human RPCC when compared to normal kidney tissues (t=44.38,P=0.000). Similarly, the expression of STAT1 was higher in the RPCC cell line when compared to firbroblast and Wilm's tumor cell lines. STAT1 expression was inhibited by beth fludarabine and siRNA. Radiosensitivity in RPCC cell lines was enhanced by both fludarabine and siRNA induced STAT1 inhibition. Conclusions This is the first study reporting the over-expression of STAT1 in human RPCC tissues and human RPCC cell line. Radiesensitization of RPCC is observed via inhibition of STAT1 signaling by fludarabine and siRNA techniques. Our data suggests that STAT1, through IFN-signalling pathway , may play a key role in RPCC radioresistance and manipulation of this pathway may enhance the efficacy of radiotherapy.

Objective: To investigate the relationship between serum leptin concentration and diet nutrition, age and gender. Method: One hundred fifty-eight men and women aged 18-72 y were initially drawn from a community in Jinan City. The parameters measured included height, weight and serum leptin concentrations. In addition, a 3-d food record was used to represent usual food intake by the participants. Results: The mean serum leptin concentration in males was 8.38?6.31ng/ml, while in females 24.98?13.29 ng/ml. Serum leptin level in males was significantly correlated with age, but not in females. Respectively, serum leptin level in males and females were not correlated to dietary factors. After adjusted for BMI, serun leptin level in females was positively correlated with dietary intake of fat, MUFA and PUFA. Conclusion: Serum leptin level in female is higher than that in male. Age is correlated to serum leptin level in males. The relation of dietary intake of fat, MUFA and PUFA to serum leptin concentration only existed in women.

Objective To investigate the characteristics of children′s recurrent abdominal pain(RAP) with gastroscopy and analyze the etiology.Methods Three hundred and thirteen children were investigated with gastroscopy.Gastric antrum mucosa was taken for histo-pathology and the determination of helicobacter pylori(Hp) antibody.Results Ninty-nine point six eight percent of the cases had lesions under the gastroscope.The former 4 cases had chronic superficial gastritis(CSG),CGS and bile reflux,CGS and duodenitis,CGS and bulb ulcer,and Hp infection rate was 31.36%,25%,38.64%,60.61%.Hp infection rates of active gastritis and inactive gastritis were 92% and 23.19%,which showed significant differences in 2 groups(P

Abstract: Objective　To investigate the impacts of vaccination with inactivated SARS-COV-2 vaccine on the clinical manifestations and serological responses of COVID-19 patients infected by Delta and Alpha variants. Methods　Clinical and experimental data of 341 confirmed SARS-COV-2 patients were collected from The Eighth Affiliated Hospital of Guangzhou Medical University May 1- September 30, 2021. The subjects were divided into Delta and Alpha variant group according to virus variants, and were divided into vaccinated group and unvaccinated group according to whether they had received inactivated COVID-19 vaccine or not. The clinical manifestations and serological responses of patients with Delta and Alpha variant, and vaccinated and unvaccinated patients with Delta and Alpha variants were compared. Results　Totally 253 patients were infected with Delta variant (103 vaccinated and 150 unvaccinated patients), and 88 patients were infected with Alpha variant (21 vaccinated and 67 unvaccinated patients). The proportion of asymptomatic infection in Delta variants group was significantly lower than that in Alpha variants group (P<0.01). Delta variant group of vaccination rates and vaccine breakthrough infection rate was 40.7% (103/253) and 22.9% (58/253), were higher than Alpha variant group was 23.9% (21/88) and 8.0% (7/88), difference was statistically significant (χ2= 8.009, 9.484, P<0.01). The proportion of cough and fever in Delta variant group was higher than that in Alpha variant group (both P<0.01), the peak viral load was higher than that of Alpha variant group (P<0.01), the virus duration was longer than that of Alpha variant group (P<0.01), the levels of SAA, CRP and IFN were higher than those of Alpha variant group (all P<0.05), CD4+T cell count was lower than that of Alpha variant group (P<0.05), IgG and IgM levels were lower than those of Alpha variant group (both P<0.01). The proportion of moderate COVID-19 in the vaccinated group was lower than that in the unvaccinated group (P<0.01). In these two variants, the peak viral load of vaccinated group was lower than that of the unvaccinated group (both P<0.01), the duration of virus was shorter than that of unvaccinated group (both P<0.01). The levels of SAA, CRP and IL-6 in the vaccinated group were lower than those in the unvaccinated group (all P<0.05), CD4+T cell level was higher than that of unvaccinated group (both P<0.05), IgG and IgM level were higher than those in unvaccinated group (both P<0.05). Conclusions　Delta variant can lead to higher viral load and more severe disease course, which is associated with vaccine breakthrough infection. Inactivated vaccines for COVID-19 can reduce severe illness and death by reducing viral load, disease duration and inflammatory response through humoral and cellular immune mechanisms.

OBJECTIVETo inquire into the reason why the postoperative complications of augmentation mammaplasty by injecting polyacrylamide hydrogel took place and to find the best method to deal with the complications.

METHODS12 patients who accepted polyacrylamide hydrogel injection for augmentation mammaplasty were included in this study. Operations were performed to remove the polyacrylamide hydrogel.

RESULTSAll patients didn't argue with the result, but the outside shape of mamma was not good post-operation.

CONCLUSIONSSo-called standard injection method can't avoid the postoperative complications. The considerable therapy for the complications of polyacrylamide hydrogel was removing it by operation.

Acrylic Resins ; adverse effects ; Adult ; Breast Implants ; adverse effects ; Female ; Humans ; Postoperative Complications ; etiology ; Young Adult